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Modulation of Host Cell Death Pathways by Yersinia Species and the Type III Effector YopK

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Advances in Yersinia Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 954))

Abstract

Pneumonic plague, caused by Yersinia pestis, is characterized by bacterial evasion and manipulation of the mammalian innate immune system. Following an initial anti-inflammatory response to infection in the lung, bacteria grow rapidly accompanied by host cell death and a massive inflammatory response. Phagocytic cells, in particular macrophages, are targeted and eliminated by the bacterial type III secretion system. In this work, we discuss the mechanisms by which the type III secretion system regulates host cell death during pulmonary infection by Y. pestis. We focus on the role of effector Yops E, J and K in this process and how they coordinately regulate cell death mechanisms that lead to precise control over inflammation during infection.

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Author information

Authors and Affiliations

  1. Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, USA

    Kristen N. Peters & Deborah M. Anderson

  2. Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, USA

    Kristen N. Peters

  3. Laboratory for Infectious Disease Research, University of Missouri, Columbia, MO, USA

    Kristen N. Peters & Deborah M. Anderson

Authors
  1. Kristen N. Peters
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  2. Deborah M. Anderson
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Correspondence to Deborah M. Anderson .

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Editors and Affiliations

  1. , Centro de Pesquisa Aggeu Magalhães, Campus da UFPE, Recife, 50670, Brazil

    Alzira Maria Paiva de Almeida

  2. , Centro de Pesquisa Aggeu Magalhães, Campus da UFPE, Recife, 50670-420, Brazil

    Nilma Cintra Leal

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Peters, K.N., Anderson, D.M. (2012). Modulation of Host Cell Death Pathways by Yersinia Species and the Type III Effector YopK. In: de Almeida, A., Leal, N. (eds) Advances in Yersinia Research. Advances in Experimental Medicine and Biology, vol 954. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3561-7_29

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