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Arsenic and Primary Human Cells

  • Reference work entry
Encyclopedia of Metalloproteins

  • 64 Accesses

Synonyms

Apoptosis; Arsenical compounds; Mode of action

Definition of the Subject

The subject of arsenic and primary human cells refers to the role of arsenical compounds in the physiology of cells of primary origin. The importance of this subject resides in the fact that most of the studies reported in the literature focus on the role of arsenic in cancer cells or in immortalized cancer cell lines, but very few deal with the arsenic-primary cell interaction. Primary cells are those that are directly isolated from blood (immune origin) or isolated from a tissue or organ (nonimmune origin) like epithelial or hepatocyte cells. Because arsenical compounds may be toxic or, paradoxically, could be used in the treatment of diverse diseases, it is important to better understand how these compounds alter primary cells of different origins.

Generalities

Metalloids are elements that are neither metals nor nonmetals and this group includes boron, silicon, germanium, tellurium, antimony, and...

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Authors and Affiliations

  1. Laboratoire de recherche en inflammation et physiologie des granulocytes, Université du Québec, INRS-Institut Armand-Frappier, 531 boul. des Prairies, Laval, QC, Canada

    Dr. Denis Girard Ph.D.

Authors
  1. Dr. Denis Girard Ph.D.
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Correspondence to Denis Girard Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Biology, University of Virginia, Charlottesville, VA, USA

    Robert H. Kretsinger

  2. Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL, USA

    Vladimir N. Uversky

  3. Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, Russia

    Eugene A. Permyakov

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Girard, D. (2013). Arsenic and Primary Human Cells. In: Kretsinger, R.H., Uversky, V.N., Permyakov, E.A. (eds) Encyclopedia of Metalloproteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1533-6_436

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