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Selenium

Its Molecular Biology and Role in Human Health

  • Book
  • © 2012

Overview

Editors:
  1. Dolph L. Hatfield

    1. National Cancer Institute, Basic Research Laboratory, National Institutes of Health, Bethesda, USA

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  2. Marla J. Berry

    1. University of Hawaii, Monoa, Honolulu, USA

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  3. Vadim N. Gladyshev

    1. , Division of Genetics, Department of Medi, Brigham and Women’s Hospital and Harvard, Boston, USA

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  • Provides an overview of the health benefits of Selenium
  • Brings the research on selenium up-to-date
  • Explains how selenium becomes a protein
  • Includes supplementary material: sn.pub/extras

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About this book

Many health benefits have been attributed to selenium that include preventing various forms of cancer (e.g., colon cancer, prostate cancer, lung cancer and liver cancer), heart disease and other cardiovascular and muscle disorders, inhibiting viral expression, delaying the progression of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV)-positive patients, slowing the aging process, and having roles in mammalian development, including male reproduction and immune function. The purpose of the book is the same as the first two volumes which is to bring an up to date status of current research in the rapidly developing selenium field centered around the health benefits attributed to this element and how this element makes its way into protein.

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Table of contents (45 chapters)

  1. Front Matter

    Pages i-xxv
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  2. History of Selenium Research

    • Elias S. J. Arnér
    Pages 1-19

  3. Selenocysteine Biosynthesis and Incorporation into Protein

    1. Front Matter

      Pages 21-21
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  4. Selenocysteine biosynthesis and incorporation into protein

    1. Selenocysteine Biosynthesis and the Replacement of Selenocysteine with Cysteine in the Pathway

      • Xue-Ming Xu, Anton A. Turanov, Bradley A. Carlson, Min-Hyuk Yoo, Vadim N. Gladyshev, Dolph L. Hatfield
      Pages 23-31

    2. Molecular Mechanism of Eukaryotic Selenocysteine Incorporation

      • Michael T. Howard, Jonathan N. Gonzales-Flores, Paul R. Copeland
      Pages 33-46

    3. SECIS-Binding Proteins Regulate the Expression of the Selenoproteome

      • Donna M. Driscoll, Jodi L. Bubenik
      Pages 47-59

    4. A Ribosomal Perspective on the Mechanism of Selenocysteine Incorporation

      • Kelvin Caban, Paul R. Copeland
      Pages 61-72

    5. Chemical Basis for the Use of Selenocysteine

      • Erik L. Ruggles, Gregg W. Snider, Robert J. Hondal
      Pages 73-83

    6. Evolutionary Basis for the Use of Selenocysteine

      • Louise White, Sergi Castellano
      Pages 85-93

    7. Selenocysteine Lyase: Mechanism, Structure, and Biological Role

      • Hisaaki Mihara, Nobuyoshi Esaki
      Pages 95-105

  5. Selenoproteins and Selenoproteins in Health

    1. Front Matter

      Pages 107-107
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  6. Selenoproteins and selenoproteins in health

    1. Selenoproteins and Selenoproteomes

      • Vadim N. Gladyshev
      Pages 109-123

    2. Structural Characterization of Mammalian Selenoproteins

      • Stefano M. Marino, Vadim N. Gladyshev, Alexander Dikiy
      Pages 125-136

    3. Selenoproteins: Hierarchy, Requirements, and Biomarkers

      • Roger A. Sunde
      Pages 137-152

    4. Selenoproteins and the Thioredoxin System

      • Jun Lu, Arne Holmgren
      Pages 153-165

    5. Selenoproteins of the Glutathione Peroxidase Family

      • Leopold Flohé, Regina Brigelius-Flohé
      Pages 167-180

    6. Glutathione Peroxidase-4

      • Matilde Maiorino, Valentina Bosello, Giorgio Cozza, Antonella Roveri, Stefano Toppo, Fulvio Ursini
      Pages 181-195

    7. Selenoprotein M

      • Mariclair A. Reeves, Marla J. Berry
      Pages 197-203

    8. Selenium Transport in Mammals: Selenoprotein P and Its Receptors

      • Josef Köhrle, Ulrich Schweizer, Lutz Schomburg
      Pages 205-219

    9. Selenoproteins in the Endoplasmic Reticulum

      • Dmitri E. Fomenko
      Pages 221-234
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Editors and Affiliations

  • National Cancer Institute, Basic Research Laboratory, National Institutes of Health, Bethesda, USA

    Dolph L. Hatfield

  • University of Hawaii, Monoa, Honolulu, USA

    Marla J. Berry

  • , Division of Genetics, Department of Medi, Brigham and Women’s Hospital and Harvard, Boston, USA

    Vadim N. Gladyshev

Bibliographic Information

  • Book Title: Selenium

  • Book Subtitle: Its Molecular Biology and Role in Human Health

  • Editors: Dolph L. Hatfield, Marla J. Berry, Vadim N. Gladyshev

  • DOI: https://doi.org/10.1007/978-1-4614-1025-6

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Softcover ISBN: 978-1-4899-9445-5Published: 25 January 2014

  • eBook ISBN: 978-1-4614-1025-6Published: 13 November 2011

  • Edition Number: 3

  • Number of Pages: XXVI, 598

  • Topics: Biochemistry, general, Nutrition, Immunology

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