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DNA Topoisomerases and Cancer

  • Book
  • © 2012

Overview

Editors:
  1. Yves Pommier

    1. Laboratory of Molecular Pharmacology, National Institutes of Health Laboratory of Molecular Pharmacology, Bethesda, USA

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  • Structure and mechanism of eukaryotic type IIA topoisomerases
  • DNA topoisomerase I and illegitimate recombination
  • Mechanism regulating cellular responses to DNA topoisomerase I-targeted agents

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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About this book

DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Introduction and Historical Perspective

    • Patrick Forterre
    Pages 1-52

  3. Human DNA Topoisomerase I: Structure, Enzymology and Biology

    • James J. Champoux
    Pages 53-69

  4. Mitochondrial Topoisomerases

    • Ilaria Dalla Rosa, Yves Pommier, Hongliang Zhang
    Pages 71-85

  5. Structure and Mechanism of Eukaryotic Type IIA Topoisomerases

    • James M. Berger, Neil Osheroff
    Pages 87-101

  6. Essential Functions of Topoisomerase IIIα in the Nucleus and Mitochondria

    • Stefanie Hartman Chen, Jianhong Wu, Tao-shih Hsieh
    Pages 103-117

  7. DNA Topoisomerase I and Illegitimate Recombination

    • Céline Auzanneau, Philippe Pourquier
    Pages 119-143

  8. Topoisomerase-Induced DNA Damage

    • Yves Pommier, Neil Osheroff
    Pages 145-154

  9. Topoisomerases and Carcinogenesis: Topoisomerase IIIα and BLM

    • Mounira Amor-Guéret, Jean-François Riou
    Pages 155-173

  10. Topoisomerases Inhibitors: A Paradigm for Interfacial Inhibition

    • Christophe Marchand, Yves Pommier
    Pages 175-184

  11. Topoisomerase I Inhibitors: Chemical Biology

    • Beverly A. Teicher
    Pages 185-210

  12. Topoisomerase II Inhibitors: Chemical Biology

    • Anna Rogojina, Stefan Gajewski, Karim Bahmed, Neil Osheroff, John L. Nitiss
    Pages 211-243

  13. Topoisomerase I Inhibitors: Current Use and Prospects

    • Yan Makeyev, Franco Muggia, Arun Rajan, Giuseppe Giaccone, Takahisa Furuta, Philippe Rougier
    Pages 245-277

  14. Topoisomerase II Inhibitors: Current Use and Prospects

    • Olivier Mir, William Dahut, François Goldwasser, Christopher Heery
    Pages 279-307

  15. Transcriptional Stress by Camptothecin: Mechanisms and Implications for the Drug Antitumor Activity

    • Giovanni Capranico, Laura Baranello, Davide Bertozzi, Jessica Marinello
    Pages 309-324

  16. Mechanisms Regulating Cellular Responses to DNA Topoisomerase I-Targeted Agents

    • Piero Benedetti, Mary-Ann Bjornsti
    Pages 325-334

  17. Tyrosyl-DNA-Phosphodiesterase

    • Thomas S. Dexheimer, Shar-yin N. Huang, Benu Brata Das, Yves Pommier
    Pages 335-354

  18. Ubiquitin and Ubiquitin-Like Proteins in Repair of Topoisomerase-Mediated DNA Damage

    • Shyamal D. Desai
    Pages 355-379

  19. Repair of Topoisomerase II-Mediated DNA Damage: Fixing DNA Damage Arising from a Protein Covalently Trapped on DNA

    • John L. Nitiss, Eroica Soans, Jeffrey Berk, Aman Seth, Margarita Mishina, Karin C. Nitiss
    Pages 381-407

  20. Topoisomerases and Apoptosis

    • Olivier Sordet, Stéphanie Solier
    Pages 409-435
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Editors and Affiliations

  • Laboratory of Molecular Pharmacology, National Institutes of Health Laboratory of Molecular Pharmacology, Bethesda, USA

    Yves Pommier

Bibliographic Information

  • Book Title: DNA Topoisomerases and Cancer

  • Editors: Yves Pommier

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-4614-0323-4

  • Publisher: Humana New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-4614-0322-7Published: 20 September 2011

  • Softcover ISBN: 978-1-4614-2963-0Published: 25 October 2013

  • eBook ISBN: 978-1-4614-0323-4Published: 21 September 2011

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XI, 443

  • Number of Illustrations: 16 b/w illustrations, 49 illustrations in colour

  • Topics: Cancer Research, Pharmacology/Toxicology

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