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Concepts in Viral Pathogenesis III pp 87–95Cite as

Transforming Genes of Bovine and Human Papillomaviruses

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Abstract

Papillomaviruses (PVs) induce benign epithelial tumors in their natural hosts. The best-characterized members of this virus group are the human papillomaviruses (HPV), bovine papillomaviruses (BPV), and cottontail rabbit papillomavirus (CRPV). PVs have also been isolated from many other mammals, as well as from birds. More than 50 different HPV genotypes have now been identified [1–3].

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References

  1. Lancaster WD, and Olson C (1982) Animal papillomaviruses. Microbiol Rev 46: 191–207

    PubMed  CAS  Google Scholar 

  2. Broker TR, Botchan M (1986) Papillomaviruses: Retrospectives and prospectives. In Botchan M, Grodzicker T, Sharp PA, (eds.) Cancer Cells 4. DNA Tumor Viruses. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp 17–36

    Google Scholar 

  3. Salzman NP, Howley PM (eds.) (1987) The Papovaviridae 2: The Papillomaviruses. Plenum Publishing, New York, 387 p

    Google Scholar 

  4. Orth G (1987) Epidermodysplasia verruciformis. In Salzman NP, Howley PM (eds) The Papovaviridae 2: The Papillomaviruses. Plenum Publishing, New York, pp 199–243

    Google Scholar 

  5. Zur Hausen H, Schnieder A (1987) The role of papillomaviruses in human anogenital cancer. In Salzman NP, Howley PM (eds) The Papovaviridae 2: The Papillomaviruses. Plenum Publishing, New York, pp 245–263

    Google Scholar 

  6. Pettersson U, Ahola H, Stenlund A, Moreno-Lopez J (1987) Organization and expression of papillomavirus genomes. In Salzman NP, Howley PM (eds) The Papovaviridae 2: The Papillomaviruses. Plenum Publishing, New York, pp 67–107

    Google Scholar 

  7. Dvoretzki I, Shober R, Chattopadhyay SK, Lowy DR (1980) A quantitative in vitro focus forming assay for bovine papillomavirus. Virology 103: 516–528

    Google Scholar 

  8. DiMaio D, Neary K (1989) The gentics of bovine papillomavirus type 1. In Pfister H (ed) Papillomaviruses and Human Cancer (in press)

    Google Scholar 

  9. Lambert PF, Howley PM (1988) The genetics of bovine papillomavirus type 1. Ann Rev Genet 22: 235–258

    Article  PubMed  CAS  Google Scholar 

  10. Schiller J, Vousden K, Vass WC, Lowy DR (1986) The E5 open reading frame of bovine papillomavirus type 1 encodes a transforming gene. J Virol 57: 1–6

    PubMed  CAS  Google Scholar 

  11. Groff DE, Lancaster WD (1986) Genetics analysis of the 3’ early region transformation and replication functions of bovine papillomavirus type 1. Virology 150: 221–230

    Article  PubMed  CAS  Google Scholar 

  12. Smith KT, Campo MS (1988) “Hit and run” transformation of mouse C127 cells by bovine papillomavirus type 4: The viral DNA is required for the initiation but not for maintenance of the transformed phenotype. Virology 164: 39–47

    Article  PubMed  CAS  Google Scholar 

  13. Neary K, DiMaio D (1989) Open reading frames E6 and E7 of bovine papillomavirus type 1 are both required for full transformation of mouse C127 cells. J Virol 63: 259–266

    PubMed  CAS  Google Scholar 

  14. Lambert PF, Howley PM (1988) Bovine papillomavirus type 1 El replication-defective mutants are altered in their transcriptional regulation J Virol 62: 4009–4015

    PubMed  CAS  Google Scholar 

  15. Schiller JT, Kleiner E, Androphy EJ, Lowy DR, Pfister H (1989) Identification of bovine papillomavirus El mutants with increased transforming and transcriptional activity J Virol 63: 1775–1720

    CAS  Google Scholar 

  16. Prakash SS, Horwitz BH, Zibello TZ, Settleman J, DiMaio D (1988) Bovine papillomavvirus E2 gene regulates expression of the viral E5 transforming gene. J Virol 62: 3608–3613

    PubMed  CAS  Google Scholar 

  17. Horwitz BH, Burkhardt AL, Schlegel R, DiMaio D (1988) 44-Amino-acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal acino acids. Mol Cell Biol 8: 4071–4078

    Google Scholar 

  18. Green M, Loewenstein PM (1987) Demonstration that a chemically synthesized BPV1 oncoprotein and its C-terminal domain function to induce cellular DNA synthesis. Cell 51: 795–802

    Article  PubMed  CAS  Google Scholar 

  19. Barbosa MS, Lowy DR, Schiller JT (1989) Papillomavirus polypeptides E6 and E7 are zinc-binding proteins. J Virol 63: 1404–1407

    PubMed  CAS  Google Scholar 

  20. Androphy EJ, Schiller JT, Lowy DR (1985) Identification of the protein ncoded by the E6 transforming gene of bovine papillomavirus. Science 230: 442–445

    Article  PubMed  CAS  Google Scholar 

  21. Vousden KH, Androphy EJ, Schiller JT, Lowy DR (1989) Mutational analyis of bovine papillomavirus E6 gene. J Virol (in press)

    Google Scholar 

  22. Storey A, Pim D, Murrary A, Osborn K, Banks L, Crawford L (1988) Comparison of the in vitro transforming activities of human papillomavirus types. EMBO J 7: 1815–1820

    PubMed  CAS  Google Scholar 

  23. Schlegel R, Phelps WC, Zhang YL, Barbosa M (1988) Quantitative keratinocyte assay detects two biological activities of human papillomavirus DNA and identifies viral types assocaited with cervical carcinoma. EMBO J 7: 3181–3187

    PubMed  CAS  Google Scholar 

  24. Pater MM, Hughes GA, Hyslop DE, Nakshatri H, Pater A (1988) Glucocorticoid-dependent oncogenic transformation by type 16 but not type 11 human papilloma virus DNA. Nature 335: 832–835

    Article  PubMed  CAS  Google Scholar 

  25. Bedell MA, Jones KH, Laimins LA (1987) The E6–E7 region of human papillomavirus type 18 is sufficient for transformation of NIH 3T3 and rat-1 cells. J Virol 61: 3635–3640

    PubMed  CAS  Google Scholar 

  26. Vousden KH, Doniger J, DiPaolo JA, Lowy DR (1988) The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene. Oncogene Res 3: 167–175

    PubMed  CAS  Google Scholar 

  27. Kanda T, Furuno A, Yoshiike K (1988) Human papillomavirus type 16 open reading frame E7 encodes a transforming gene for rat 3Y1 cell. J Virol 62: 610–617

    PubMed  CAS  Google Scholar 

  28. Watanabe S, Yoskiike K (1988) Transformation of rat 3Y1 cells by human papillomavirus type-18 DNA. Intl J Cancer 41: 896–900

    Article  CAS  Google Scholar 

  29. Kanda T, Watanabe S, Yoshiike K (1988) Immortalization of primary rat cells by human papillomavirus type 16 subgenomic DNA fragments controlled by the SV40 promoter. Virology 165: 321–325

    Article  PubMed  CAS  Google Scholar 

  30. Yutsudo M, Okamoto Y, Hakura A (1988) Functional dissociation of transforming genes of human papillomavirus type 16. Virology 166: 594–597

    Article  PubMed  CAS  Google Scholar 

  31. Phelps WC, Yee CL, Munger K, Howley PM (1988) The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A. Cell 53: 539–547

    Article  PubMed  CAS  Google Scholar 

  32. Iftner T, Bierfelder S, Csapo Z, Pfister H (1988) Involvement of human papillomavirus type 8 genes E6 and E7 in transformation and replication. J Virol 62: 3655–3661

    PubMed  CAS  Google Scholar 

  33. Edmonds C, Vousden K (1989) A point mutational analysis of HPV16 E7 protein: Transformation is separable from trans-activation in NIH 3T3 cells J Virol (in press)

    Google Scholar 

  34. Dyson N, Howley PM, Munger K, Harlow E (1989) The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243: 934–937

    Article  PubMed  CAS  Google Scholar 

  35. Smotkin D, Wettstein FO (1987) The major-human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein J Virol 61: 1686–1689

    PubMed  CAS  Google Scholar 

  36. Culp JF, Webster LC, Friedman DJ, Smith CL, Huang W-J, Wu FY-H, Rosenberg M, Ricciardi RP (1988) The 289-amino acid Ela protein of adenovirus binds zinc in a region that is important for trans-activation. Proc Natl Acad Sci USA 85: 6450–6465

    Article  PubMed  CAS  Google Scholar 

  37. Androphy EJ, Hubbert NL, Schiller JT, Lowy DR (1987) Identification of the HPV-16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines. EMBO J 6: 898–992

    Google Scholar 

  38. Pirisi L, Yasumoto S, Feller M, Doniger J, DiPaolo J (1987) Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. J Virol 61: 1061–1066

    PubMed  CAS  Google Scholar 

  39. Woodworth CD, Bowden PE, Doniger J, Pirisi L, Barnes W, Lancaster WD, DiPaolo JA (1988) Characterization of normal human exocervical epithelial cells immortalized in vitro by papillomavirus types 16 and 128 DNA. Cancer Res 48: 4620–4628

    PubMed  CAS  Google Scholar 

  40. Riou G, Barrois M, Sheng Z-M, Duvillard P, Lhomme C (1988) Somatic deletions and mutations of c-Ha-ras gene in human cervical cancers. Oncogene 3: 329–333

    PubMed  CAS  Google Scholar 

  41. McCance DJ, Kopan R, Fuchs E, Laimins LA (1988) Human papillomavirus type 16 alters human epitheila cells differentiation in vitro. Proc Natl Acad Sci USA 85: 7169–7173

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Douglas R. Lowy
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  2. John T. Schiller
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Editor information

Editors and Affiliations

  1. Laboratory of Oral Medicine, National Institute of Dental Research, NIH, 20892, Bethesda, Maryland, USA

    Abner Louis Notkins M.D.

  2. Department of Immunology, Scripps Clinic and Research Foundation, 92037, La Jolla, California, USA

    Michael B. A. Oldstone M.D.

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© 1989 Springer-Verlag New York Inc.

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Lowy, D.R., Schiller, J.T. (1989). Transforming Genes of Bovine and Human Papillomaviruses. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis III. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8890-6_10

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  • DOI: https://doi.org/10.1007/978-1-4613-8890-6_10

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8892-0

  • Online ISBN: 978-1-4613-8890-6

  • eBook Packages: Springer Book Archive

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