Abstract
From previous studies there is ample evidence that phosphate, in addition to its proximal reabsorption is reabsorbed at some postproximal site (1–3,5,6,8,9,11). In free flow micropuncture studies this reabsorption has at least partially been ascribed to the distal tubule and collecting duct system (1,5). In microinjection studies, on the other hand, no reabsorption of phosphate beyond the loop of Henle could be detected (4,10). These data, however, are methodologically not unequivocal since the phosphate load injected exceeded the amount of phosphate which ought to be expected there under conditions of free flowing tubular fluid. The free flow micropuncture data also are subject to restricted interpretation since it seems likely that nephron heterogeneity in regard to phosphate reabsorption exists between superficial cortical and deeper nephrons.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Amiel, C., H. Kuntziger, and G. Richet: Micropuncture study of handling of phosphate by proximal and distal nephron in normal and parathyroidectomized rat. Evidence for distal reabsorption. Pflügers Arch. 317:93–109, 1970.
Beck, L.H., and M. Goldberg: Effects of acetazolamide and parathyroidectomy on renal transport of sodium, calcium and phosphate. Am. J. Physiol. 224:1136–1142, 1973.
Beck, L.H., and M. Goldberg: Mechanism of the blunted phospha-turia in saline-loaded thyroparathyroidectomized dogs. Kidney Int. 6:18–23, 1974.
Brunette, M.G., L. Taleb, and S. Carriere: Effect of parathyroid hormone on phosphate reabsorption along the nephron of the rat. Am. J. Physiol. 225:1076–1081, 1973.
Chiu, P.J.S., Z.S. Agus, and M. Goldberg: Effect of thyroparat-hyroidectomy (TPTX) on renal phosphate transport in the rat. Clin. Res. 22:520, 1974 (Abstr.).
Knox, F.G., and C. Lechene: Distal site of action of parathyroid hormone on phosphate reabsorption. Am.J.Physiol. 229:1556–1560, 1975.
Knox, F.G., E.G. Schneider, L.R. Willis, J.W. Strandhoy, and C.E. Ott: Site and control of phosphate reabsorption by the kidney. Kidney Int. 3:347–353, 1973.
Kuntziger, H., C. Amiel, and C. Gaudebout: Phosphate handling by the rat nephron during saline diuresis. Kidney Int. 2:318–323, 1972.
Maesaka, J.K., M.F. Levitt, and R.G. Abramson: Effect of saline infusion on phosphate transport in intact and thyroparathyroidectomized rats. Am.J.Physiol. 225:1421–1429, 1973.
Staum, B.B., R.J. Hamburger, and M. Goldberg: Tracer microinjection study of renal tubular phosphate reabsorption in the rat. J.Clin.Invest. 51; 2271–2276, 1972.
Wen, S.F.: Micropuncture studies of phosphate transport in the proximal tubule of the dog. J.Clin.Invest. 53:143–153, 1974.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Springer Science+Business Media New York
About this chapter
Cite this chapter
Greger, R., Lang, F., Marchand, G., Knox, F.G. (1977). The Postproximal Site of Phosphate Reabsorption in Presence and Absence of Parathyroid Hormone. In: Massry, S.G., Ritz, E. (eds) Phosphate Metabolism. Advances in Experimental Medicine and Biology, vol 81. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-4217-5_17
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4217-5_17
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4613-4219-9
Online ISBN: 978-1-4613-4217-5
eBook Packages: Springer Book Archive