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Mechanisms of Cancer Metastasis

Potential Therapeutic Implications

  • Book
  • © 1986

Overview

Editors:
  1. Kenneth V. Honn

    1. Department of Radiation Oncology, Wayne State University Harper-Grace Hospital, Detroit, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. William E. Powers

    1. Department of Radiation Oncology, Wayne State University, Detroit, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Bonnie F. Sloane

    1. Department of Pharmacology, Wayne State University, Detroit, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Oncology (DION, volume 40)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. The Cancer Problem Today

    • William E. Powers
    Pages 1-14

  3. Present Status and Future Prospects for Treatment of Metastatic Cancer

    • Bruce A. Chabner
    Pages 15-22

  4. A Critical Overview of the Metastatic Process

    • Leonard Weiss
    Pages 23-40

  5. Experimental Models for Studying the Pathogenesis and Therapy of Metastatic Disease

    • George Poste, Russell Greig
    Pages 41-68

  6. Problems Posed for Cancer Treatment by Tumor Cell Heterogeneity

    • Gloria H. Heppner
    Pages 69-79

  7. Multidrug Resistance and Metastasis

    • Victor Ling
    Pages 81-90

  8. Polyamine Biosynthesis: A Target for Antimetastatic Therapy

    • Prasad S. Sunkara, Nellikunja J. Prakash
    Pages 91-101

  9. Chemical Mechanisms of Modulation of Tumor Growth and Metastasis by Prostaglandins

    • Lawrence J. Marnett, Kenneth V. Honn
    Pages 103-115

  10. Platelet-Tumor Cell Interactions as a Target for Antimetastatic Therapy

    • K. V. Honn, J. M. Onoda, D. G. Menter, P. G. Cavanaugh, J. D. Crissman, J. D. Taylor et al.
    Pages 117-144

  11. Mechanisms of Inhibition of Cancer Dissemination by Warfarin

    • Leo R. Zacharski
    Pages 145-158

  12. Cancer Cell Procoagulants and their Possible Role in Metastasis

    • Stuart G. Gordon
    Pages 159-172

  13. Role of Growth Stimulatory Factors in Determining the Sites of Metastasis

    • Peter Alexander, Paul V. Senior, Paul Murphy, Richard Clarke
    Pages 173-191

  14. Interleukins, Lymphokines and Lymphoid Neoplasia

    • Richard J. Ford, Frances Davis, Nicola Kouttab, Shashi Mehta
    Pages 193-205

  15. The Use of Activated Macrophages for the Destruction of Heterogeneous Metastasis

    • Alan J. Schroit, Isaiah J. Fidler
    Pages 207-226

  16. Biological Response Modifiers as Activators of Natural Killer Cells: Potential Role in Treatment of Metastasis

    • Ronald B. Herberman
    Pages 227-233

  17. Breast Cancer Diagnosis with Human Mammary Epithelial Antigens and the Prospective Use of Antibodies against Them in Therapy

    • Roberto L. Ceriani, Jerry A. Peterson, Edward W. Blank
    Pages 235-257

  18. Chemotaxis in Tumor Cells: Possible Mechanisms and their Implications for Therapy

    • James Varani, J. Philip Mccoy Jr.
    Pages 259-274

  19. Invasion of Vascular Endothelium and Organ Tissue in Vitro by B16 Melanoma Variants

    • Garth L. Nicolson, Motowo Nakajima, Tatsuro Irimura
    Pages 275-297

  20. Domains of Laminin and Basement Membrane Collagen which Play a Role in Metastases

    • Lance A. Liotta, Nageswara C. Rao, Sanford H. Barsky, Taina M. Turpeenniemi-Hujanen
    Pages 299-308
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Keywords

About this book

The past twenty years have witnessed significant advances in the treatment of cancer by surgery and radiation therapy. Gains with cytotoxic chemotherapy have been much more modest. Of the approximately 900,000 newly diagnosed cases of cancer each year, 50010 result in death of the patient. The primary cause of these deaths is metastasis. Although the term metastasis was first coined by Recamier in 1829, only in the past ten years have there been intensive scientific investigations into the mechanisms by which tumor cells metastasize. What has emerged is a complex process of host-tumor cell interactions which has been termed the metastatic cascade. Due to the complexity of the metastatic process, the study of metastasis is multifaceted and involves elements of such areas as differentiation, en­ zymology, genetics, hematology, immunology, membrane biochemistry and molecular biology. The major objectives of this book were to present the most recent advances in our understanding of how tumor cells metastasize to secondary sites by the leading experts in the biology of tumor invasion and metastasis. We hope that this book will lead to new concepts for the treatment of subclinical metastatic cancer. The chapters in this book address both the basic science of metastasis and potential clinical therapies directed toward interruption of the metastatic cascade or toward eradication of subclinical metastases. Many relevant topics have been omitted due to space considerations and thus the topics included reflect the prej­ udices of the editors.

Editors and Affiliations

  • Department of Radiation Oncology, Wayne State University Harper-Grace Hospital, Detroit, USA

    Kenneth V. Honn

  • Department of Radiation Oncology, Wayne State University, Detroit, USA

    William E. Powers

  • Department of Pharmacology, Wayne State University, Detroit, USA

    Bonnie F. Sloane

Bibliographic Information

  • Book Title: Mechanisms of Cancer Metastasis

  • Book Subtitle: Potential Therapeutic Implications

  • Editors: Kenneth V. Honn, William E. Powers, Bonnie F. Sloane

  • Series Title: Developments in Oncology

  • DOI: https://doi.org/10.1007/978-1-4613-2635-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Martinus Nijhoff Publishing, Boston 1986

  • Hardcover ISBN: 978-0-89838-765-0Published: 30 November 1985

  • Softcover ISBN: 978-1-4612-9646-1Published: 04 October 2011

  • eBook ISBN: 978-1-4613-2635-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVI, 428

  • Topics: Oncology

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