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Biochemistry and Molecular Genetics of Cancer Metastasis pp 279–292Cite as

Hormonal Regulation of Metastases: Prospects for Pharmacological Manipulation

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Part of the book series: Developments in Oncology ((DION,volume 41))

Abstract

Many biological processes operate under strict paracrine and endocrine control and aberrations in these regulatory mechanisms can result in the development of disease. For decades this fundamental realization has provided the intellectual infrastructure for the design and development of several classes of pharmacological agents that have subsequently demonstrated efficacy against a spectrum of important human diseases, including diabetes, heart disease, autoimmune disorders and asthma. As our understanding of the molecular mechanisms underlying the complex etiology of each of these diseases becomes more sophisticated, new opportunities for pharmacological intervention steadily emerge. Although investigations into the hormonal1 regulation of tumorigenesis have been extensive and enjoyed a degree of diagnostic and clinical success (especially for breast carcinoma) (1,2), parallel studies on the metastatic spread of malignant tumors have received much less attention, particularly at the molecular level. If more effective therapeutic strategies are to be developed against disseminated malignant disease, then new biochemical approaches are needed to identify novel pharmacological targets unique to metastatic tumor cells.

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Author information

Authors and Affiliations

  1. Department of Tumor Biology, Smith Kline and French Laboratories, Philadelphia, PA, 19101, USA

    Russell G. Greig

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  1. Russell G. Greig
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Editor information

Editors and Affiliations

  1. I. Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, 1085, Budapest, Hungary

    Karoly Lapis

  2. Laboratory of Pathology National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Lance A. Liotta  & Alan S. Rabson  & 

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© 1986 Martinus Nijhoff Publishing, Boston

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Greig, R.G. (1986). Hormonal Regulation of Metastases: Prospects for Pharmacological Manipulation. In: Lapis, K., Liotta, L.A., Rabson, A.S. (eds) Biochemistry and Molecular Genetics of Cancer Metastasis. Developments in Oncology, vol 41. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2299-3_22

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  • DOI: https://doi.org/10.1007/978-1-4613-2299-3_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9416-0

  • Online ISBN: 978-1-4613-2299-3

  • eBook Packages: Springer Book Archive

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