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Molecular Aspects of Human B and T Lymphocyte Responses to HIV

  • Chapter
Herpesviruses, the Immune System, and AIDS

Part of the book series: Developments in Medical Virology ((DIMV,volume 6))

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Abstract

The human immunodeficiency virus type 1 (HIV-1) induces readily detectable virus-specific B and T lymphocyte responses in humans. These responses may control the infection for various periods of time but ultimately fail to prevent the development of AIDS. This chapter reviews of the human immune response to HIV-1, focusing on those immune mechanisms that may exert a beneficial anti-viral effect and those that may contribute to the pathophysiology of HIV-1 infection by promoting the depletion of CD4+ T lymphocytes. Particular emphasis is placed on a novel mechanism for the depletion of CD4+ T cells which involves cytolytic T lymphocytes (CTL) specific for the HIV-1 envelope glycoprotein gp120.

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  1. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA

    R. F. Siliciano

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  1. R. F. Siliciano
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  1. The University of Maryland, Baltimore, USA

    Laure Aurelian M.D.

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© 1990 Kluwer Academic Publishers

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Siliciano, R.F. (1990). Molecular Aspects of Human B and T Lymphocyte Responses to HIV. In: Aurelian, L. (eds) Herpesviruses, the Immune System, and AIDS. Developments in Medical Virology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1507-0_3

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  • DOI: https://doi.org/10.1007/978-1-4613-1507-0_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8810-7

  • Online ISBN: 978-1-4613-1507-0

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