Abstract
Transient leukopenia1 and change in pulmonary function2 are known to occur regular during the initial phase of hemodialysis (HD) with cuprophane membranes, suggesting that an intrapulmonary sequestration of granulocytes may happen3. Besides this, hypoxemia, complement-activation, increase of granulocyte adherence and enhanced release of granular enzymes have been reported4,5,6. In addition, alteration of granulocyte behavior such as activation of phagocytosis and impaired oxidative metabolism7,8 has been described.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
L.S. Kaplow, and L.S. Goffinet, Profound neutropenia during the early phase of hemodialysis, JAMA 203: 1135 (1968).
P.R. Craddock, J.Fehr, K.L. Brigham, and H.S. Jacobs, Complement and leukocyte mediated pulmonary dysfunction in hemodialysis, New Engl. J. Med. 296: 769 (1977).
P.R. Craddock, J.Fehr, A.P. Oalmasso, K.L. Brigham, and H.S. Jacob, Hemodialysis leukopenia: pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes, J. Clin. Invest. 59: 879 (1977).
R.M. Hakim, and G.H. Lowrie, Effect of dialyzer raise on leukopenia, hypoxemia and total hemolytic complement system, Thromb. Am. Soc. Artif. Intern. Organs 26: 159 (1980).
P. Aljama, A. Martin-Malo, R. Pérez, D. Castillo, A. Torres, and F. Velasco, Granulocyte adherence changes during hemodialysis, Contr. Nephrol. 46: 75 (1985).
R.M. Schaefer, A. Heidland, and W.H. Hörl, Release of leukocyte elastase during hemodialysis, Contr. Nephrol. 46: 109 (1985).
A.T. Nguyen, C. Lethias, J. Zingraff, A. Herbelin, C. Naret, and B. Descamps-Latscha, Hemodialysis membrane-induced activation phagocyte oxidative metabolism detected in vivo and in vitro within microamounts of whole blood, Kidney Int. 28: 158 (1985).
M.S. Cohen, D.M. Elliott, T. Chaplinski, M.M. Pike, and J.E. Niedel, A defect in the oxidative metabolism of human polymorphonuclear leukocytes that remain in circulation early in hemodialysis, Blood 60: 1283 (1982).
A. Böyum, IV. Isolation of mononuclear cells and granulocytes from human blood-isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation of 1 g, Scand. J. Clin. Lab. Invest. 21: 77 (1968).
S. Neumann, N. Hennrich, G. Gunzer, and H. Lang, Enzyme-linked immunoassay for human granulocyte elastase in complex withα1-proteinase inhibitor, in: Proteases: Potential role in health and disease, W.H. Hörl, A. HeIaIand, eds., Plenum Press, New York, London, p. 379 (1984).
J.T. Curnutte, and B.M. Babior, The effect of bacteria and serum on superoxide production by granulocytes, J. Clin. Invest. 53: 1662 (1974).
L.R. DeChatelet, G.D. Long, P.S. Shirly, D.A. Bass, M.I. Thomas, F.W. Hendergon, and M.S. Cohen, Mechanism of luminal-descendent chemiluminescence of human neutrophils, J. Immunol. 129: 1589 (1982).
K. Joseph, V. Damann, G. Engerhoff, and K.R. Gruner, Markierung von Leukozyten mit 99m-Technetium-HM-PAO: Erste klinische Ergebnisse, Nuc-Compact 5: 277 (1986).
C. Tetta, G. Camussi, G. Segolini, and A. Verlellone, Direct interaction between polymorphonuclear neutrophils (PMN) and dialysis membranes: role of the electrical charges, Kidney Int. 29: 609 (1986).
G. Weissmann, R.B. Zurier, and S. Hoffstein, Leukocytic proteases and their immunologic release of lysosomal enzymes. Am. J. Path. 68: 539 (1972).
S. Stannnat, J. Bahlmann, D. Kiessling, K.M. Koch, H. Deicher, and H.H. Peter, Complement activation during hemodialysis. Comparison of polysulfone and cuprophan membranes, Contr. Nephrol. 46: 102 (1985).
W.H. Hörl, W. Riegel, and P. Schollmeyer, Plasma levels of main’ granulocyte components in patients dialyzed with polycarbonate and cuprophane membranes, Nephron 45: 272 (1987).
A. Janoff, Proteases and lung injury. A state of - the art minireview, Chest 54: 835 (1983).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this paper
Cite this paper
Kolb, G. et al. (1988). Hemodialysis with Cuprophane Membranes Leads to Alteration of Granulocyte Oxidative Metabolism and Leukocyte Sequestion in the Lung. In: Hörl, W.H., Heidland, A. (eds) Proteases II. Advances in Experimental Medicine and Biology, vol 240. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1057-0_45
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1057-0_45
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8313-3
Online ISBN: 978-1-4613-1057-0
eBook Packages: Springer Book Archive