Skip to main content
SpringerLink
Log in

Nutritional Modulation of Oxygen Radical Pathology

  • Chapter
Advances in Nutritional Research

Part of the book series: Advances in Nutritional Research ((ANUR,volume 8))

Abstract

In the past decade the pathogenicity of oxygen radicals has emerged as a major focus of research in fundamental biology. This emergence is reflected in the appearance of numerous books and conference proceedings on the subject, of which only five are cited here (Simic et al., 1988; Chow, 1988; Halliwell, 1988a; Quintanilha, 1988a; Halliwell and Gutteridge, 1985), as well as several new periodicals devoted to the publication of ongoing research. The field has been remarkable for the rapidity with which basic research findings have been incorporated into clinical medicine. New perceptions of the role of oxygen radicals in physiological processes have led to novel strategies for the prevention or treatment of a range of pathologies, including inflammmation, immunosuppression, cataracts, radiation injury, hyperoxia, cirrhosis and cancer. The prominent involvement of nutrients in the metabolism of oxygen radicals has raised the possibility that these conditions may be subject to nutritional modulation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aust, S. D., 1988, Sources of iron for lipid peroxidation in biological systems, in: Oxygen Radicals and Tissue Injury ( B. Halliwell, ed.), pp. 27–33. Federation of American Societies for Experimental Biology, Bethesda, MD.

    Google Scholar 

  • Bergan, J. G., and Draper, H. H., 1970, Absorption and metabolism of 1-C-methyl linoleate hydroperoxide, Lipids 5: 976.

    Article  CAS  Google Scholar 

  • Bertgöld, D. S., Simic, M. G., Alessio, H., and Cutler, R. G., 1988, Urine markers for oxidative DNA damage, in: Oxygen Radicals in Biology and Medicine ( M. G. Simic, K. A. Taylor, J. E. Ward, and C. von Sonntag, eds.) pp. 483–489, Plenum Press, New York.

    Google Scholar 

  • Bettger, W. G., and Bray, T. M., 1989, Effect of dietary zinc or copper deficiency on catalase, glutathione peroxidase and superoxide dismutase activities in rat heart, Nutr. Res. 9: 319.

    Article  CAS  Google Scholar 

  • Bindoli, A., 1988, Lipid peroxidation in mitochondria, Free Rad. Biol. Med. 5: 247.

    Article  CAS  Google Scholar 

  • Braughler, J. M., Duncan, L. A., and Chase, R. L., 1986, The involvement of iron in lipid peroxidation; importance of ferric to ferrous ratios in initiation, J. Biol. Chem. 261: 1082.

    Google Scholar 

  • Burton, G. W., and Ingold, K. V., 1984, Beta carotene: an unusual type of lipid antioxidant, Science 224: 569.

    Article  CAS  Google Scholar 

  • Buttriss, J. L., and Diplock, A. T., 1988, The a-tocopherol and phospholipid fatty acid content of rat liver subcellular membranes in vitamin E and selenium deficiency, Biochim. Biophys. Acta 963:61.

    CAS  Google Scholar 

  • Cararocchi, N. C., England, M. D., O’Brien, J. F., Solis, E., Russo, P., Schaff, H. V., Orszulak, T. A., Pluth, J. R., and Kaye, M. P., 1988, Superoxide generation during cardiopulmonary bypass: is there a role for vitamin E? J. Burg. Res. 30: 519.

    Google Scholar 

  • Chan, H. W.-S, (ed.), 1987, Autoxidation of Unsaturated Lipids, Academic Press, New York.

    Google Scholar 

  • Chow, C. K., (ed.), 1988, Cellular Antioxidant Defense Mechanisms, vol. 1, 2 and 3, CRC Press, Boca Raton, Fl.

    Google Scholar 

  • Chow, C. K., Draper, H. H., and Csallany, A. S., 1969, Method for the assay of free and esterified tocopherols, Anal. Biochem. 32: 81.

    Article  CAS  Google Scholar 

  • Clark, L. C., and Combs, G. F., Jr., 1986, Selenium compounds and the prevention of cancer: research needs and public health implications, J. Nutr. 116: 170.

    CAS  Google Scholar 

  • Davies, K. J. A., and Lin, S. W., 1988, Degradation of oxidatively denatured proteins in Escherrichia coli, Free Rad. Biol. Med. 5: 215.

    Article  CAS  Google Scholar 

  • Davies, K. J. A., Lin, S. W., and Pacifici, R. E., 1987, Protein damage and degradation by oxygen radicals, W. Degradation of denatured protein, J. Biol. Chem. 262: 9914.

    CAS  Google Scholar 

  • Dhanakoti, S. N., and Draper, H. H., 1987, Response of urinary malondialdehyde to factors that stimulate lipid peroxidation in vivo, Lipids 22: 643.

    Article  CAS  Google Scholar 

  • Dolphin, D., 1988, The generation of radicals during the normal and abnormal functioning of cytochromes P-450, in: Oxygen Radicals in Biology and Medicine ( M. G. Simic, K. A. Taylor, J. F. Ward, and C. von Sonntag, eds.), pp. 491–500, Plenum Press, New York.

    Google Scholar 

  • Draper, H. H., 1980, Role of vitamin E in plants, microbes, invertebrates and fish, in: Vitamin E, a Comprehensive Treatise ( L. J. Machlin, ed.), pp. 391–396, Marcel Dekker, New York.

    Google Scholar 

  • Draper, H. H., 1988, Nutrients as nutrients and nutrients as prophylactic drugs, J. Nutr. 118: 1420.

    CAS  Google Scholar 

  • Draper, H. H., and Bird, R. P., 1984, Antioxidants and cancer, J. Agr. Food Chem. 32: 433.

    Article  CAS  Google Scholar 

  • Draper, H. H., and Hadley, M., 1988, Malondialdehyde derivatives in urine, in: Oxygen Radicals in Biology and Medicine ( M. Simic, K. A. Taylor, J. F. Ward, and C. von Sonntag, eds.), pp. 199–202, Plenum Press, New York.

    Google Scholar 

  • Duan, Y-J., Komura, S., Fiszer-Szafarz, B., Szafarz, D., and Yagi, K., 1988, Purification and characterization of a novel monomeric glutathione peroxidase from rat liver, J. Biol. Chem. 263: 19003.

    CAS  Google Scholar 

  • Dunphy, P. J., Whittle, K. J., Pennock, J. F., and Morton, R. A., 1965. Identification and estimation of tocotrienols in Hevea latex, Nature 207: 521.

    Article  CAS  Google Scholar 

  • Englard, S., and Seifter, S., 1986, The biochemical functions of ascorbic acid, Ann. Rev. Nutr. 6: 365.

    Article  CAS  Google Scholar 

  • Esterbauer, H., Zollner, H., and Schaur, R. J., 1988, Hydroxyalkenals: cytotoxic products of lipid peroxidation, ISI Atlas of Science: Biochemistry 1: 311.

    CAS  Google Scholar 

  • Forman, H. J., Skelton, D. C., Loeb, G. A., and Dorio, R. J., 1988, Membrane permeability and oxidant induced injury, in: Oxygen Radicals in Biology and Medicine ( M. Simic, K. A. Taylor, J. F. Ward, and C. von Sonntag, eds.), pp. 523–530, Plenum Press, New York.

    Google Scholar 

  • Frankel, E. N., 1987, Secondary products of lipid oxidation, Chem. Phys. Lipids 44: 73.

    Article  CAS  Google Scholar 

  • Freedman, J. H., Ciriolo, M. R., and Peisach, J., 1989, The role of glutathione in copper metabolism and toxicity, J. Bid. Chem. 264: 5598.

    CAS  Google Scholar 

  • Frei, B., Stocker, R., and Ames, B. N., Antioxidant defenses and lipid peroxidation in human blood plasma, Proc. Nat. Acad. Sci., USA 85: 9748.

    Google Scholar 

  • Fridovich, L, 1988, The biology of oxygen radicals: general concepts, in: Oxygen Radicals and Tissue Injury ( B. Halliwell, ed.), pp. 1–5, Federation of American Societies for Experimental Biology, Bethesda, MD

    Google Scholar 

  • Godin, D. V., and Wohaieb, S. A., 1988, Nutritional deficiency, starvation, and tissue antioxidant status, Free Rad. Bid Med. 5: 165.

    CAS  Google Scholar 

  • Gutteridge, J. M. C., 1988, Lipid peroxidation: some problems and concepts, in: Oxygen Radicals and Tissue Injury ( B. Halliwell, ed.), pp. 9–19, Federation of American Societies for Experimental Biology, Bethesda, MD.

    Google Scholar 

  • Haberland, M. E., Fong, D., and Cheng, L., 1988, Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits, Science 241: 215.

    Article  CAS  Google Scholar 

  • Hall, E. D., and Braughler, J. M., 1988, The role of oxygen radical-induced peroxidation in acute central nervous system trauma, in: Oxygen Radicals and Tissue Injury ( B. Halliwell, ed.), pp. 92–98, Federation of American Societies for Experimental Biology, Bethesda, MD.

    Google Scholar 

  • Halliwell, B., (ed.), 1988a, Oxygen Radicals and Tissue Injury, Proc. Brook Lodge Symposium, Augusta, Michigan, April 27–29, 1987, 148 pp., Federation of American Societies for Experimental Biology, Bethesda, MD.

    Google Scholar 

  • Halliwell, B., 1988b, A radical approach to human disease, in: Oxygen Radicals and Tissue Injury ( B. Halliwell, ed.), pp. 139–143, Federation of American Societies for Experimental Biology, Bethesda, MD.

    Google Scholar 

  • Halliwell, B., and Gutteridge, J. M. C., 1985, Free Radicals in Biology and Medicine, 346 pp., Clarendon Press, Oxford.

    Google Scholar 

  • Inoue, K., Itabe, H., and Kudo, I., 1988, Production and metabolism of cytotoxic phospholipids generated during incubation of liposomes with oxyhemoglobin, in: Oxygen Radicals in Biology and Medicine ( M. Simic, K. A. Taylor, J. F. Ward, and C. von Sonntag, eds.), pp. 291–299, Plenum Press, New York.

    Google Scholar 

  • Jamieson, D., 1988, Reactive oxygen metabolites and hyperbaric toxicity, in: Oxygen Radicals in Biology and Medicine ( M. Simic, K. A. Taylor, J. F. Ward, and C. von Sonntag, eds.), pp. 553–560, Plenum Press, New York.

    Google Scholar 

  • Kubow, S., Bray, T. M., and Bettger, W. J., 1986, Effects of dietary zinc and copper on free radical production in rat lung and liver, Can. J. Physiol. Pharmacol. 64: 1281.

    Article  CAS  Google Scholar 

  • Lemoyne, M., Van Gossum, A., Kurian, R., Ostro, M., Axier, J., and Jeejeebhoy, K. N., 1987, Breath pentane analysis as an index of lipid peroxidation: a functional test of vitamin E status, Am. J. Clin. Nutr. 46: 267.

    CAS  Google Scholar 

  • Mesaki, N., Kyle, M. E., and Farber, J. L., 1989, Tert-Butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids, Arch. Biochem. Biophys. 269: 390.

    Article  Google Scholar 

  • Mathews-Roth, M. M., 1986, Beta carotene therapy for erythropoietic protoporphyria and other photosensitivity diseases, Biochimie 68: 875.

    Article  CAS  Google Scholar 

  • Michiels, C., and Remade, J., 1988, Microinjection of antioxidant enzymes to protect cells from oxygen derived free radicals, in: Oxygen Radicals in Biology and Medicine ( M. Simic, K. A. Taylor, J. F. Ward, and C. von Sonntag, eds.), pp. 703–711, Plenum Press, New York.

    Google Scholar 

  • Nalbone, G., Leonardi, J., Termine, E., Portugal, H., Lechene, P., Pauli, A.-M., and Lafont, H., Effects of fish oil, corn oil and lard diets on lipid peroxidation status and glutathione peroxidase activities in rat heart, Lipids 24: 179.

    Google Scholar 

  • Niki, W., Yamamoto, Y., Takahashi, M, Yamamoto, K., Yamamoto, Y., Komuro, E., Mild, M., Yasuda, H., and Mina, M., 1988, Free radical-induced damage of blood and its inhibition by antioxidants, J. Nutr. Sci. Vitaminol. 34: 507.

    Article  CAS  Google Scholar 

  • O’Brien, P. J., 1987, Oxidation of lipids in biological membranes and intracellular consequences, in: Autoxidation of Unsaturated Lipids ( H. WS. Chan, ed.), pp. 233–280, Academic Press, New York.

    Google Scholar 

  • Pascoe, G. A., and Reed, D. J., 1989, Cell calcium, vitamin E, and the thiol redox system in cytotoxicity, Free Rad. Biol. Med. 6: 209.

    Article  CAS  Google Scholar 

  • Piché, L. A., Cole, P. D., Hadley, M., van den Bergh, R., and Draper, H. H., 1988, Identification of N-e-(2-pmpenol) lysine as the main form of malondialdehyde in food digeste, Carginogenesis 9: 473.

    Article  Google Scholar 

  • Quintanilha, A., (ed.), 1988a. Reactive Oxygen Species in Chemistry, Biology, and Medicine, 232 pp., Plenum Press, New York

    Google Scholar 

  • Quintanilha, A. T., 1988b, Oxidative effects of physical exercise, in: Reactive Oxygen Species in Chemistry, Biology and Medicine ( A. Quintanilha, ed.), pp. 187–195, Plenum Press, New York.

    Google Scholar 

  • Schatzkin, A., Hoover, R. N., Taylor, P. R., Ziegler, R. G., Carter, C. L., Albanes, D., Larson, D. B., and Licitra, L. M., 1988, Site-specific analysis of total serum cholesterol and incident cancer in the National Health and Nutrition Examination Survey, I. Epidemiologic follow-up study, Cancer Res. 48: 452.

    CAS  Google Scholar 

  • Sevanian, A., and Hochstein, P., 1985, Mechanisms and consequences of lipid peroxidation in biological systems, Ann. Rev. Nutr. 5: 365.

    Article  CAS  Google Scholar 

  • Sheehan, M-M., 1947, The ascorbic acid content of the blood serum of farm animals, J. Comp. Path. 57: 28.

    Google Scholar 

  • Simic, M. G., Taylor, K. A., Ward, J. F., and von Sonntag, C., eds., 1988, Oxygen Radicals in Biology and Medicine, Proc. Fourth Intern. Congress on Oxygen Radicals, June 27-July 3, 1987, LaJolla, California, 1085 pp., Plenum Press, New York.

    Google Scholar 

  • Simmons, K., 1986, Evaluating vitamin prophylaxis for cancer, JAMA 265: 1832.

    Article  Google Scholar 

  • Tan, K. H., Meyer, D. J., Gillies, N., and Ketterer, B., 1988, Detoxification of DNA hydroperoxide by glutathione transferases and the purification and characterization of glutathione transferases of the rat liver nucleus, Biochem. J. 254: 841.

    CAS  Google Scholar 

  • Tappel, A. L., 1982, Measurement of in vivo lipid peroxidation via exhaled pentane and protection by vitamin E, in: Lipid Peroxides in Biology and Medicine ( K. Yagi, ed.). pp. 213–222, Academic Press, New York.

    Google Scholar 

  • Taylor, C. G., Bettger, W. J., and Bray, T. M., 1988, Effect of dietary zinc or copper deficiency on the primary free radical defense system in rats, J. Nutr. 118: 613.

    CAS  Google Scholar 

  • U. S. National Research Council, Committee on Diet and Health, Food and Nutrition Board, Commission on Life Sciences, 1989, Diet and Health, National Academy Press, Washington, DC, 20 pp.

    Google Scholar 

  • Wattenberg, L. W., 1982, Inhibition of chemical carcinogens by minor dietary components, in: Molecular Interrelations of Nutrition and Cancer (M. S. Arnott, J. van Eye, and Y. M. Wang, eds.), Raven Press, New York, pp. 43–56.

    Google Scholar 

  • Witting, L. A., 1965, Lipid peroxidation in vivo, J. Am. Oil Chem. Soc. 42: 908.

    Article  CAS  Google Scholar 

  • Witting, L. A., 1974, Vitamin E-polyunsaturated lipid relationship in diet and tissues, Am. J. Clin. Nutr. 27: 952.

    CAS  Google Scholar 

  • Yang, G., Chang, J., Wen, Z., Ge, K., Zhu, L., Chen, X., and Chen, X., 1984, The role of selenium in Keshan disease, Adv. Nutr. Res. 6: 203.

    CAS  Google Scholar 

  • Yeagle, P. L., 1989, Lipid regulation of cell membrane structure and function, FASEB J. 3: 1833.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, ON, N1G 2W1, Canada

    Harold H. Draper

Authors
  1. Harold H. Draper
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Guelph, Guelph, Ontario, Canada

    Harold H. Draper

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Plenum Press, New York

About this chapter

Cite this chapter

Draper, H.H. (1990). Nutritional Modulation of Oxygen Radical Pathology. In: Draper, H.H. (eds) Advances in Nutritional Research. Advances in Nutritional Research, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0611-5_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-0611-5_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7891-7

  • Online ISBN: 978-1-4613-0611-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation