Abstract
The presence of ε-N-methyllysine was first observed in Salmonella typhimurium in 1959. Since this discovery the ubiquitous occurrence of protein methylation in nature has been well established (Paik & Kim, 1980). It involves N-methylation of lysine, arginine, histidine, alanine, proline, and glutamine, O-methylation of glutamic and aspartic acid, and S-methylation of methionine and cysteine (Paik & Kim, 1985). As shown in Table I, methylated amino acids occur in highly specialized proteins such as histones, flagella protein, myosin, actin, ribosomal proteins, opsin, EFlα(Tu), HnRNP protein, HMG-1 and HMG-2 protein, fungal and plant cytochrome c, myelin basic protein, porcine heart citrate synthase, heat-shock proteins, nucleolar protein, ferredoxin, wheat α-amylase, and calmodulin.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Ahlgren, J. A. and Ordal, G. W. (1983) Biochem. J. 213,759.
Aswad, D. W. and Deight, W. A. (1983) J. Neurochem. 40, 1718.
Crang, A. J. and Jacobson, W. (1982) J. Neurochem. 39, 244.
DiMaria, P., Kim, S. and Paik, W. K. (1982) Biochemistry 21, 1036.
DiMaria, P., Polastro, E., DeLange, R. J., Kim, S. and Paik, W. K. (1979) J. Biol. Chem. 254, 4645.
Durban, E., Nochumson, Kim, S. and Paik, W. K. (1978) J. Biol. Chem. 253, 1427.
Farooqui, J., Tuck, M. and Paik, W. K. (1985) J. Biol. Chem 260, 537.
Galletti, P., Paik, W. K. and Kim, S. (1979) Eur. J. Biochem 97, 221.
Gupta, A., Jensen, D., Kim, S. and Paik, W. K. (1982) J. Biol. Chem. 257, 9677.
Kim, C.-S., Kueppers, F., DiMaria, P., Farooqui, J., Kim, S., and Paik, W. K. (1980) Biochim. Biophys. Acta 622, 144.
Kim, S. (1974) Arch. Biochem. Biophys. 161, 652.
Kim, S., Nochumson, S., Chin, W. and Paik, W. K. (1978) Anal. Biochem. 84, 415.
Kim, S., Tuck, M., Kim, M., Campagnoni, A. T. and Paik, W. K. (1984) Biochem. Biophys. Res. Communs. 123, 468.
Kleene, S. J., Toews, M. L. and Adler, J. (1977) J. Biol. Chem. 252, 3214.
Lee, H. W., Kim, S. and Paik, W. K. (1977) Biochemistry 16, 78.
Paik, W. K. and Kim, S. (1970) J. Biol. Chem. 245, 6010.
Paik, W. K. and Kim, S. (1980) Protein Methylation, John Wiley & Sons, New York.
Paik, W. K. and Kim, S. (1985) The Enzymology of Post-Translational Modification of Proteins, Vol. 2 (Freedman, R. and Hawkins, H. C., Ed.), Academic Press (London), in press
Sitaramayya, A., Wright, L. S. and Siegel, F. L. (1980) J. Biol. Chem. 255, 8894.
Tuck, M., Farooqui, J. and Paik, W. K. (1985) J. Biol. Chem. 260, 7114.
Valentine, J. and Pettigrew, G. W. (1982) Biochem. J. 201, 329.
Van der Werf, P. and Koshland, D. E. jr. (1977) J. Biol. Chem. 252, 2793.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 The Humana Press Inc.
About this chapter
Cite this chapter
Paik, W.K., Kim, S., Lee, H.W. (1986). Enzymology of Protein Methylation: Recent Development. In: Borchardt, R.T., Creveling, C.R., Ueland, P.M. (eds) Biological Methylation and Drug Design. Experimental Biology and Medicine, vol 12. Humana Press. https://doi.org/10.1007/978-1-4612-5012-8_2
Download citation
DOI: https://doi.org/10.1007/978-1-4612-5012-8_2
Publisher Name: Humana Press
Print ISBN: 978-1-4612-9398-9
Online ISBN: 978-1-4612-5012-8
eBook Packages: Springer Book Archive