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The Thrombopoietin Receptor, Mpl, and Signal Transduction

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Thrombopoiesis and Thrombopoietins

Abstract

The recent identification and characterization of the c-mpl proto-oncogene set off an explosive wave of research that has advanced our understanding of megakaryocyte and platelet biology immensely. The mechanisms by which this member of the hemopoietic cytokine receptor family promotes the survival, proliferation, and differentiation of megakaryocytic progenitors resulting in platelet production will require many years, if not decades, to unravel completely. However, important insights into this process have already been achieved, and will be reviewed in this chapter.

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Authors
  1. Kenneth Kaushansky
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  2. Virginia C. Broudy
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  3. Jonathan G. Drachman
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Editor information

Editors and Affiliations

  1. The MGH Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA

    David J. Kuter MD, DPhil

  2. Amgen Inc., Thousand Oaks, California, USA

    Pamela Hunt PhD  & William Sheridan MD  & 

  3. Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA

    William Sheridan MD

  4. Department of Medicine, New York University Medical Center, New York, New York, USA

    Dorothea Zucker-Franklin MD

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© 1997 Humana Press Inc.

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Kaushansky, K., Broudy, V.C., Drachman, J.G. (1997). The Thrombopoietin Receptor, Mpl, and Signal Transduction. In: Kuter, D.J., Hunt, P., Sheridan, W., Zucker-Franklin, D. (eds) Thrombopoiesis and Thrombopoietins. Humana Press. https://doi.org/10.1007/978-1-4612-3958-1_16

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  • DOI: https://doi.org/10.1007/978-1-4612-3958-1_16

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8440-6

  • Online ISBN: 978-1-4612-3958-1

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