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Nitric Oxide and the Regulation of the Peripheral Circulation pp 148–165Cite as

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Inhaled Nitric Oxide Therapy for Acute Respiratory Failure

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Part of the book series: Nitric Oxide in Biology and Medicine ((NOBM,volume 1))

Abstract

Pulmonary hypertension and severe hypoxemia complicate the care of patients with diseases such as the acute respiratory distress syndrome (ARDS). Numerous vasodilator therapies aimed at reducing pulmonary hypertension have been tested in these patients. All of the currently available intravenous vasodilators produce systemic vasodilation and hypotension at dosages sufficient to reduce the pulmonary artery pressure. In addition, intravenous infusions of systemic vasodilators such as nitroprusside or prostacyclin (prostaglandin I2; PGI2) markedly increase the venous admixture (Radermacher et al. 1990). In 1991, inhaled nitric oxide (NO) was reported to selectively vasodilate the pulmonary circulation (Fratacci et al. 1991; Frostell et al. 1991). The use of this novel therapy as an adjunct in the treatment of ARDS has attracted immense interest.

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  1. William E. Hurford
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  2. Wolfgang Steudel
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Editors and Affiliations

  1. Department of Pharmacology, Tulane University Medical Center, New Orleans, LA, 70112-2699, USA

    Philip J. Kadowitz Ph.D.  & Dennis B. McNamara Ph.D.  & 

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Hurford, W.E., Steudel, W., Zapol, W.M. (2000). Inhaled Nitric Oxide Therapy for Acute Respiratory Failure. In: Kadowitz, P.J., McNamara, D.B. (eds) Nitric Oxide and the Regulation of the Peripheral Circulation. Nitric Oxide in Biology and Medicine, vol 1. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-1326-0_10

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