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Pharmacological Characterization of Receptor Types

  • Chapter
The Tachykinin Receptors

Part of the book series: The Receptors ((REC))

Abstract

The various biological actions of substance P and related tachykinins/neurokinins are mediated by three different receptor types, which were named NK1, NK2 and NK3 during the Montreal Symposium in 1986 (Henry, 1987). The three receptors have been characterized pharmacologically (Regoli et al., 1987a, Regoli et al., 1988, Regoli et al., 1989), biochemically (Lavielle et al., 1988; Buck et al., 1991), and genetically (Nakanishi, 1991). In vivo activities have been attributed to each receptor by Maggi et al. (1987), Regoli et al. (1988), and Maggi et al. (1993). Cloning and sequencing of receptors and the study of receptor properties of mRNA expressed in special systems (Nakanishi, 1991) appear to validate the three physiological entities.

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  1. Domenico Regoli
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  2. Noureddine Rouissi
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  3. Pedro D’Orléans-Juste
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  1. Biopharm Consultists, Tucson, AZ, USA

    Stephen H. Buck

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Regoli, D., Rouissi, N., D’Orléans-Juste, P. (1994). Pharmacological Characterization of Receptor Types. In: Buck, S.H. (eds) The Tachykinin Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0301-8_13

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  • DOI: https://doi.org/10.1007/978-1-4612-0301-8_13

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