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Human Fetal Tissue Transplantation

  • Book
  • © 2013

Overview

Editors:
  1. Niranjan Bhattacharya

    1. Kolkata, India

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    You can also search for this editor in PubMed   Google Scholar

  2. Phillip Stubblefield

    1. Dept. Obstetrics & Gynaecology, Boston University Medical Centre, Boston, USA

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    You can also search for this editor in PubMed   Google Scholar

  • This is a new area of translational research and has immense potential in clinical medicine, particularly regenerative medicine

  • Bring together the new work of prominent medical scientists and clinicians conducting pioneering research in human fetal tissue transplant

  • Include direct transplant of healthy fetal tissue into mature patients as well as in hosts with genetic diseases

  • Transplant techniques, donor-host interaction, cell and tissue storage, ethical and legal issues, are some of the matters which the book will deal with

  • The book will include advances in both theory and practice in the last two decades

  • Includes supplementary material: sn.pub/extras

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Table of contents (37 chapters)

  1. Front Matter

    Pages i-xxix
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  2. The Ideas Behind This Book

    1. Front Matter

      Pages 1-1
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    2. Alternatives of Human Organ/Tissue Transplantation

      • Niranjan Bhattacharya, Phillip Stubblefield
      Pages 3-13

    3. Fetomaternal Cell Trafficking: A Window into the Long-Term Health Effects of Treating Disease with Fetal Cell/Tissue Transplants?

      • Niranjan Bhattacharya, Phillip Stubblefield
      Pages 15-23

  3. Basic Science and the Unique Aspect of Fetal Growth and Maturation

    1. Front Matter

      Pages 25-25
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    2. Embryology of Fetal Tissue

      • Peter Hollands
      Pages 27-46

    3. Three-Dimensional Culture of Fetal Mouse, Rat, and Porcine Hepatocytes

      • Yasuyuki Sakai, Jinlan Jiang, Sanshiro Hanada, Hongyug Huang, Takeshi Katsuda, Nobuhiko Kojima et al.
      Pages 47-63

    4. Response of Fetal and Adult Cells to Growth Factors

      • Harris Pratsinis, Andreas A. Armatas†, Dimitris Kletsas
      Pages 65-77

    5. Accommodation and the Fetus

      • Ines Silva, Cody A. Koch, Raymond J. Lynch, Jeffrey L. Platt
      Pages 79-85

    6. Wharton’s Jelly-Derived Mesenchymal Stromal Cells as Immunoregulatory Cells

      • M. L. Weiss, Yelica López, K. R. McIntosh
      Pages 87-105

    7. Pluripotent Stem Cells of the Mammalian Early Embryo

      • Maria P. De Miguel, Jon Schoorlemmer, Ignacio Garcia-Tuñón
      Pages 107-119

    8. Stem Cells in Fetal Tissue (The Kidney as a Model)

      • Oren Pleniceanu, Benjamin Dekel
      Pages 121-140

    9. Potential Therapeutic Applications of Placental-Derived Stem Cells to Combat Tissue Inflammation and Fibrosis

      • Yuben Moodley, Ursula Manuelpillai
      Pages 141-157

  4. Fetal Cell Transplant Experiments in Animal and Human Systems

    1. Front Matter

      Pages 159-159
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    2. Experiences with In Utero Transplantation of Mesenchymal Stem Cells

      • Carolyn Troeger, Irina Perahud, Eva Visca, Wolfgang Holzgreve
      Pages 161-168

    3. In Utero Hematopoietic Stem Cell Transplantation for Congenital Disorders

      • Amar Nijagal, Tippi C. MacKenzie
      Pages 169-175

    4. Tissue and Progenitor Cell Transplantation for the Management of Pituitary Disorders: From Harvey Cushing to the Next Frontier

      • Courtney Pendleton, Alfredo Quinones-Hinojosa
      Pages 177-184

    5. Fetal Cell Therapy and Tissue Engineering for Musculoskeletal Tissues

      • Nathalie Hirt-Burri, Lee Ann Applegate
      Pages 185-192

    6. Cell Therapy for Parkinson’s Disease

      • Yasushi Kondo, Tsuyoshi Okuno, Sayaka Asari, Shin-ichi Muramatsu
      Pages 193-203

    7. Transplantation of Human Fetal Liver Cells into Children or Human Fetuses

      • Jean-Louis Touraine
      Pages 205-218
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About this book

Many diseases earlier considered to be incurable are now being treated with modern innovations involving fetal tissue transplants and stem cells derived from fetal tissues. Fetal tissues are the richest source of fetal stem cells as well as other varying states of differentiated cells and support or stromal cells. The activity of such stem cells is at their peak provided they are given the correct niche. Stem cells, as we know, are immortal cells with the capacity to regenerate into any kind of differentiated cell as per niche-guidance. As such, fetal tissues have the potential capacity to mend, regenerate and repair damaged cells or tissues in adults, when directly transplanted to the site of injury, or even when transplanted in some other site, because it may have a homing capacity to migrate to the site of the specific injured organ. This is a new area of translational research and needs to be highlighted because of its immense potential. This book will bring together the new work of prominent medical scientists and clinicians who are conducting pioneering research in human fetal tissue transplantation. This will include direct transplant of healthy fetal tissue into mature patients as well as in hosts with genetic diseases. Transplant techniques, donor-host interaction, cell and tissue storage, ethical and legal issues, are some of the many matters which the book will deal with.

Editors and Affiliations

  • Kolkata, India

    Niranjan Bhattacharya

  • Dept. Obstetrics & Gynaecology, Boston University Medical Centre, Boston, USA

    Phillip Stubblefield

About the editors

Niranjan Bhattacharya,

Chairman , Department of Applied Cellular with Translational Science

with Therapy and Sr Consultant and Advisor, Dept of General Surgery , Ob/Gyn,

B.P.Poddar Hospital,

Advanced Medical Research Institute Hospitals ,

Vidyasagore State Hospital, Calcutta , India

Bibliographic Information

  • Book Title: Human Fetal Tissue Transplantation

  • Editors: Niranjan Bhattacharya, Phillip Stubblefield

  • DOI: https://doi.org/10.1007/978-1-4471-4171-6

  • Publisher: Springer London

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag London 2013

  • Hardcover ISBN: 978-1-4471-4170-9Published: 07 March 2013

  • Softcover ISBN: 978-1-4471-7198-0Published: 23 August 2016

  • eBook ISBN: 978-1-4471-4171-6Published: 26 February 2013

  • Edition Number: 1

  • Number of Pages: XXIX, 462

  • Topics: Hematology, Pathology

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