Abstract
Mild therapeutic hypothermia (TH) maintained at 32–34°C for 12–24 h has been shown in clinical trials to significantly improve neurological outcomes for patients recovering from out-of-hospital cardiac arrest (OHCA), as reviewed elsewhere in this book [1, 2]. Though guidelines now recommend cooling for all patients who remain comatose after resuscitation from ventricular fibrillation OHCA, the optimal time to initiate a cooling protocol has not been specified. The question of whether it is advantageous and safe for emergency medical services (EMS) personnel to begin TH immediately post-resuscitation in the pre-hospital setting remains controversial [3]. This chapter will review the evidence on pre-hospital TH and propose an operational guide for program development among interested EMS agencies.
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Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346(8):549–56.
Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346(8):557–63.
Emergency Cardiac Care Committee. 2005 American Heart Association Guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2005;112(24 Suppl):IV1–203.
Kuboyama K, Safar P, Radovsky A, Tisherman SA, Stezoski SW, Alexander H. Delay in cooling negates the beneficial effect of mild resuscitative cerebral hypothermia after cardiac arrest in dogs: a prospective, randomized study. Crit Care Med. 1993;21(9): 1348–58.
Abella BS, Zhao D, Alvarado J, Hamann K, Vanden Hoek TL, Becker LB. Intra-arrest cooling improves outcomes in a murine cardiac arrest model. Circulation. 2004;109(22):2786–91.
Nozari A, Safar P, Stezoski SW, et al. Critical time window for intra-arrest cooling with cold saline flush in a dog model of cardiopulmonary resuscitation. Circulation. 2006;113(23):2690–6.
Callaway CW, Tadler SC, Katz LM, Lipinski CL, Brader E. Feasibility of external cranial cooling during out-of-hospital cardiac arrest. Resuscitation. 2002;52(2):159–65.
Virkkunen I, Yli-Hankala A, Silfvast T. Induction of therapeutic hypothermia after cardiac arrest in prehospital patients using ice-cold Ringer’s solution: a pilot study. Resuscitation. 2004;62(3):299–302.
Kamarainen A, Virkkunen I, Tenhunen J, Yli-Hankala A, Silfvast T. Prehospital induction of therapeutic hypothermia during CPR: a pilot study. Resuscitation. 2008;76(3):360–3.
Storm C, Schefold JC, Kerner T, et al. Prehospital cooling with hypothermia caps (PreCoCa): a feasibility study. Clin Res Cardiol. 2008;97(10):768–72.
Bruel C, Parienti JJ, Marie W, et al. Mild hypothermia during advanced life support: a preliminary study in out-of-hospital cardiac arrest. Crit Care. 2008;12(1): R31.
Uray T, Malzer R. Out-of-hospital surface cooling to induce mild hypothermia in human cardiac arrest: a feasibility trial. Resuscitation. 2008;77(3):331–8.
Hammer L, Vitrat F, Savary D, et al. Immediate prehospital hypothermia protocol in comatose survivors of out-of-hospital cardiac arrest. Am J Emerg Med. 2009;27(5):570–3.
Hinchey PR, Myers JB, Lewis R, et al. Improved out-of-hospital cardiac arrest survival after the sequential implementation of 2005 AHA guidelines for compressions, ventilations, and induced hypothermia: the Wake County experience. Ann Emerg Med. 2010; 56(4):348–57.
Mooney MR, Unger BT, Boland LL, et al. Therapeutic hypothermia after out-of-hospital cardiac arrest: evaluation of a regional system to increase access to cooling. Circulation. 2011;124(2):206–14.
Kim F, Olsufka M, Longstreth Jr WT, et al. Pilot randomized clinical trial of prehospital induction of mild hypothermia in out-of-hospital cardiac arrest patients with a rapid infusion of 4 degrees C normal saline. Circulation. 2007;115(24):3064–70.
Bernard SA, Smith K, Cameron P, et al. Induction of therapeutic hypothermia by paramedics after resuscitation from out-of-hospital ventricular fibrillation cardiac arrest: a randomized controlled trial. Circulation. 2010;122(7):737–42.
Leary M, Vanek F, Abella BS. Prehospital use of therapeutic hypothermia after resuscitation from cardiac arrest. Ther Hypothermia Temp Manag. 2011;1(2): 69–75.
Cabanas JG, Brice JH, De Maio VJ, Myers B, Hinchey PR. Field-induced therapeutic hypothermia for neuroprotection after out-of hospital cardiac arrest: a systematic review of the literature. J Emerg Med. 2011;40(4):400–9.
Suffoletto BP, Salcido DD, Menegazzi JJ. Use of prehospital-induced hypothermia after out-of-hospital cardiac arrest: a survey of the National Association of Emergency Medical Services Physicians. Prehosp Emerg Care. 2008;12(1):52–6.
Mader TJ. The effect of ambient temperature on cold saline during simulated infusion to induce therapeutic hypothermia. Resuscitation. 2009;80(7):766–8.
Merchant RM, Abella BS, Peberdy MA, et al. Therapeutic hypothermia after cardiac arrest: unintentional overcooling is common using ice packs and conventional cooling blankets. Crit Care Med. 2006;34(12 Suppl):S490–4.
Moran JL, Peter JV, Solomon PJ, et al. Tympanic temperature measurements: are they reliable in the critically ill? A clinical study of measures of agreement. Crit Care Med. 2007;35(1):155–64.
Merchant RM, Becker LB, Abella BS, Asch DA, Groeneveld PW. Cost-effectiveness of therapeutic hypothermia after cardiac arrest. Circ Cardiovasc Qual Outcomes. 2009;2(5):421–8.
Kamarainen A, Virkkunen I, Tenhunen J, Yli-Hankala A, Silfvast T. Prehospital therapeutic hypothermia for comatose survivors of cardiac arrest: a randomized controlled trial. Acta Anaesthesiol Scand. 2009;53(7): 900–7.
Nielsen N, Sunde K, Hovdenes J, et al. Adverse events and their relation to mortality in out-of-hospital cardiac arrest patients treated with therapeutic hypothermia. Crit Care Med. 2011;39(1):57–64.
Nolan JP, Morley PT, Vanden Hoek TL, et al. Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation. Circulation. 2003;108(1):118–21.
Castren M, Nordberg P, Svensson L, et al. Intra-arrest transnasal evaporative cooling: a randomized, prehospital, multicenter study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness). Circulation. 2010; 122(7):729–36.
Vanden Hoek TL, Kasza KE, Beiser DG, et al. Induced hypothermia by central venous infusion: saline ice slurry versus chilled saline. Crit Care Med. 2004;32(9 Suppl):S425–31.
Staffey KS, Dendi R, Brooks LA, et al. Liquid ventilation with perfluorocarbons facilitates resumption of spontaneous circulation in a swine cardiac arrest model. Resuscitation. 2008;78(1):77–84.
Riter HG, Brooks LA, Pretorius AM, Ackermann LW, Kerber RE. Intra-arrest hypothermia: both cold liquid ventilation with perfluorocarbons and cold intravenous saline rapidly achieve hypothermia, but only cold liquid ventilation improves resumption of spontaneous circulation. Resuscitation. 2009;80(5):561–6.
Garrett JS, Studnek JR, Blackwell T, et al. The association between intra-arrest therapeutic hypothermia and return of spontaneous circulation among individuals experiencing out of hospital cardiac arrest. Resuscitation. 2011;82(1):21–5.
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© 2012 Springer-Verlag London
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Wallace, S.K., Abella, B.S. (2012). Pre-hospital Therapeutic Hypothermia. In: Lundbye, J. (eds) Therapeutic Hypothermia After Cardiac Arrest. Springer, London. https://doi.org/10.1007/978-1-4471-2951-6_2
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DOI: https://doi.org/10.1007/978-1-4471-2951-6_2
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