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Animal Models of Bone Metastasis

  • Chapter
The Biology of Skeletal Metastases

Part of the book series: Cancer Treatment and Research ((CTAR,volume 118))

Abstract

Animal models are important tools to investigate the pathogenesis and develop treatment strategies for bone metastases as they occur in humans. However, there are few spontaneous models of bone metastasis despite the fact that rodents (rats and mice) and other animals, such as dogs and cats, often spontaneously develop cancer. Therefore, most experimental models of bone metastasis in rodents require injection or implantation of neoplastic cells into orthotopic locations, bones, or the left ventricle of the heart.

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Authors and Affiliations

  1. Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA

    Thomas J. Rosol, Sarah H. Tannehill-Gregg & Stephanie Corn

  2. Department of Periodontics, Prevention, and Geriatrics, University of Michigan, Ann Arbor, MI, USA

    Abraham Schneider & Laurie K. McCauley

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  1. Thomas J. Rosol
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  2. Sarah H. Tannehill-Gregg
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  3. Stephanie Corn
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  4. Abraham Schneider
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  5. Laurie K. McCauley
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Editors and Affiliations

  1. University of Michigan Comprehensive Cancer Center University of Michigan School of Medicine, University of Michigan, Ann Arbor, Michigan, USA

    Evan T. Keller DVM, PhD (Associate Professor of Urology, Comparative Medicine and Pathology) (Associate Professor of Urology, Comparative Medicine and Pathology)

  2. Emory University School of Medicine, Emory University, Atlanta, Georgia, USA

    Leland W. K. Chung PhD (Professor of Urology, Hematology/Oncology, Biochemistry and the Winship Cancer Institute) (Professor of Urology, Hematology/Oncology, Biochemistry and the Winship Cancer Institute)

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Rosol, T.J., Tannehill-Gregg, S.H., Corn, S., Schneider, A., McCauley, L.K. (2004). Animal Models of Bone Metastasis. In: Keller, E.T., Chung, L.W.K. (eds) The Biology of Skeletal Metastases. Cancer Treatment and Research, vol 118. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9129-4_3

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