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Signaling Pathways in Squamous Cancer pp 201–222Cite as

NF-κB, IκB Kinase and Interacting Signal Networks in Squamous Cell Carcinomas

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Abstract

Nuclear factor-κB (NF-κB) transcription factors and the IκB kinases (IKKs) that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-κB signaling also has a critical role in cancer development and progression. The canonical NF-κB pathway contributes to squamous cell carcinoma (SCC) development by interacting with other signaling pathways including tumor suppressive and oncogenic pathways in a tissue specific manner. In this chapter, we will summarize recent advances in the understanding of interconnections between NF-κB and IKKs, including IKKα which has NF-κB independent functions, in the context of SCC development and progression and as potential target for novel chemotherapy approaches.

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Authors and Affiliations

  1. Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA, 92093-0723, USA

    Michael Karin

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  1. Antonio Costanzo
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  2. Giulia Spallone
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  3. Michael Karin
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Correspondence to Michael Karin .

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Editors and Affiliations

  1. Center for Molecular Toxicology &, Carcinogenesis, Pennsylvania State University, University Park, 16801, Pennsylvania, USA

    Adam B. Glick

  2. National Institute on Deafness &, Other Communication Disorders, National Institute of Health, Bethesda, 20892, Maryland, USA

    Carter Van Waes

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Costanzo, A., Spallone, G., Karin, M. (2011). NF-κB, IκB Kinase and Interacting Signal Networks in Squamous Cell Carcinomas. In: Glick, A., Waes, C. (eds) Signaling Pathways in Squamous Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7203-3_10

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