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Folding for the Synapse

  • Book
  • © 2011

Overview

Editors:
  1. Andreas Wyttenbach

    1. School of Biological Sciences, University of Southampton, Southampton, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  2. Vincent O'Connor

    1. School of Biological Sciences, University of Southampton, Southampton, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  • Introduces important concepts of folding machineries.

  • Gives examples of the biological relevance of further chaperone functions.

  • Addresses the current view on how protein folding and misfolding contribute to synapse function and dysfunction.

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-viii
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  2. The Regulation of Protein (mis)folding, Aggregation and Degradation of Proteins by Molecular Chaperones

    1. Front Matter

      Pages 7-7
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  3. Folding for the Synapse

    1. Folding for the Synapse

      • Andreas Wyttenbach, Vincent O’Connor
      Pages 1-6

  4. The regulation of protein (mis)folding, aggregation and degradation of proteins by molecular chaperones

    1. Front Matter

      Pages 7-7
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    2. Protein Aggregation: Opposing Effects of Chaperones and Crowding

      • R. John Ellis
      Pages 9-34

    3. Molecular Chaperones as Facilitators of Protein Degradation

      • Jörg Höhfeld, Nikolaus Dick, Verena Arndt
      Pages 35-48

    4. The Small Heat-Shock Proteins: Cellular Functions and Mutations Causing Neurodegeneration

      • C. d’Ydewalle, J. Krishnan, V. Timmerman, L. Van Den Bosch
      Pages 49-77

  5. The Making of the Synapse: Transport of Proteins, Vesicles and Organelles

    1. Front Matter

      Pages 79-79
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    2. Keeping it Together. Axonal Transport to the Synapse and the Effects of Molecular Chaperones in Health and Disease

      • Christopher Sinadinos, Amrit Mudher
      Pages 81-103

    3. Mechanisms of Neuronal Mitochondrial Transport

      • F. Anne Stephenson, Kieran Brickley
      Pages 105-119

  6. Chaperone modalities and homeostatic mechanisms in the synaptic compartment

    1. Front Matter

      Pages 121-121
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    2. Molecular Chaperones in the Mammalian Brain: Regional Distribution, Cellular Compartmentalization and Synaptic Interactions

      • Andreas Wyttenbach, Shmma Quraishe, Joanne Bailey, Vincent O’Connor
      Pages 123-144

    3. Cysteine-String Protein’s Role at Synapses

      • Konrad E. Zinsmaier, Mays Imad
      Pages 145-176

    4. The Role of Protein SUMOylation in Neuronal Function

      • Kevin A. Wilkinson, Jeremy M. Henley
      Pages 177-199

    5. The Ubiquitin–Proteasome System in Synapses

      • Suzanne Tydlacka, Shi-Hua Li, Xiao-Jiang Li
      Pages 201-212

  7. Chronic neurodegeneration associated with protein misfolding and synaptic dysfunction

    1. Front Matter

      Pages 213-213
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    2. VAPB Aggregates and Neurodegeneration

      • P. Skehel
      Pages 215-231

    3. Synaptic Dysfunction in Huntington’s Disease

      • Dervila Glynn, A. Jennifer Morton
      Pages 233-255

    4. Synaptic Dysfunction in Parkinson’s Disease: From Protein Misfolding to Functional Alterations

      • Tiago Fleming Outeiro, Luísa Vaqueiro Lopes
      Pages 257-267

    5. Synapses and Alzheimers’s Disease: Effect of Immunotherapy?

      • Nathan C. Denham, James A. R. Nicoll, Delphine Boche
      Pages 269-287
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About this book

Folding for the Synapse addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction. Molecular chaperones have been studied in relation to de novo protein folding, but there is increasing awareness that chaperone function is required for the regulation of protein dynamics when functioning physiologically as an isolated moiety or part of a protein complex. This book will introduce both important concepts of folding machineries and give examples of the biological relevance of further chaperone functions.

Editors and Affiliations

  • School of Biological Sciences, University of Southampton, Southampton, United Kingdom

    Andreas Wyttenbach, Vincent O'Connor

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