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Protein Homeostasis in Models of Aging and Age-Related Conformational Disease

  • Chapter
Protein Metabolism and Homeostasis in Aging

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 694))

Abstract

The stability of the proteome is crucial to the health of the cell, and contributes significantly to the lifespan of the organism. Aging and many age-related diseases have in common the expression of misfolded and damaged proteins. The chronic expression of damaged proteins during disease can have devastating consequences on protein homeostasis (proteostasis), resulting in disruption of numerous biological processes. This chapter discusses our current understanding of the various contributors to protein misfolding, and the mechanisms by which misfolding, and accompanied aggregation/toxicity, is accelerated by stress and aging. Invertebrate models have been instrumental in studying the processes related to aggregation and toxicity of disease-associated proteins and how dysregulation of proteostasis leads to neurodegenerative diseases of aging.

These authors contributed equally

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Authors and Affiliations

  1. Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, 2205 Tech Drive, Hogan 2-100, Evanston, Illinois, 60208, USA

    Elise A. Kikis, Tali Gidalevitz & Richard I. Morimoto

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  1. Elise A. Kikis
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  2. Tali Gidalevitz
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Correspondence to Richard I. Morimoto .

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  1. Institute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology Hellas (FORTH), Heraklion, Crete, Greece

    Nektarios Tavernarakis PhD

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Kikis, E.A., Gidalevitz, T., Morimoto, R.I. (2010). Protein Homeostasis in Models of Aging and Age-Related Conformational Disease. In: Tavernarakis, N. (eds) Protein Metabolism and Homeostasis in Aging. Advances in Experimental Medicine and Biology, vol 694. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7002-2_11

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