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Sphingolipids as Signaling and Regulatory Molecules pp 118–130Cite as

Ceramide-1-Phosphate in Cell Survival and Inflammatory Signaling

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 688))

Abstract

An important metabolite of ceramide is ceramide-1-phosphate (C1P). This lipid second messenger was first demonstrated to be mitogenic for fibroblasts and macrophages and later shown to have antiapoptotic properties. C1P is also an important mediator of the inflammatory response, by stimulating the release of arachidonic acid through activation of group IVA cytosolic phospholipase A2, the initial rate-limiting step of eicosanoid biosynthesis. C1P is formed from ceramide by the action of a specific ceramide kinase (CerK), which is distinct from the sphingosine kinases that synthesize sphingosine-1-phosphate. CerK is specific for natural ceramides with the erythro configuration in the base component and esterified to long-chain fatty acids. CerK can be activated by different agonists, including interleukin 1-beta, macrophage colony stimulating factor, or calcium ions. Most of the effects of C1P so far described seem to take place in intracellular compartments; however, the recent observation that C1P stimulates cell migration implicates a specific plasma membrane receptor that is coupled to a Gi protein. Therefore, C1P has a dual regulatory capacity acting as an intracellular second messenger to regulate cell survival, or as extracellular receptor ligand to stimulate chemotaxis.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country, P.O. Box 644, 48080, Bilbao, Spain

    Antonio Gómez-Muñoz, Patricia Gangoiti, María H. Granado, Lide Arana & Alberto Ouro

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  1. Antonio Gómez-Muñoz
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  2. Patricia Gangoiti
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  3. María H. Granado
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  4. Lide Arana
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  5. Alberto Ouro
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Correspondence to Antonio Gómez-Muñoz .

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Editors and Affiliations

  1. Department of Biochemistry, Virginia Commonwealth University, Richmond, Virginia, USA

    Charles Chalfant PhD

  2. Department of Biochemistry, Medical University of South Carolina, Charleston, South Carolina, USA

    Maurizio Del Poeta MD

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Gómez-Muñoz, A., Gangoiti, P., Granado, M.H., Arana, L., Ouro, A. (2010). Ceramide-1-Phosphate in Cell Survival and Inflammatory Signaling. In: Chalfant, C., Poeta, M.D. (eds) Sphingolipids as Signaling and Regulatory Molecules. Advances in Experimental Medicine and Biology, vol 688. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6741-1_8

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