Skip to main content
SpringerLink
Log in
Book cover

Crossroads between Innate and Adaptive Immunity III pp 143–159Cite as

Incorporation of Innate Immune Effector Mechanisms in the Formulation of a Vaccine Against HIV-1

  • Conference paper
  • First Online:

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 780))

Abstract

The realization of a major role for events that occur during acute viremia that dictate the course of disease both in HIV-1 infected humans and susceptible SIV infected non-human primates has prompted an intense interest in studies of the contribution of innate immune effector mechanisms. It is reasoned that findings from such studies may be important and need to be incorporated into the design and formulation of potential candidate vaccines against HIV-1. This review serves to outline the various non-human primate models that can best serve to address this issue, a summary of our knowledge on the various subsets of NK cells (one of the major innate immune cell lineage) that have an impact on the course of disease, the potential pathways that regulate their function and the potential role of the KIRs on SIV-induced disease course. Finally, the major points from this report and the data presented on similar subjects by other investigators is utilized to provide a summary of the potential future directions that we need to take in efforts to move this field forward.

Supported by NIH RO1 AI078773 and the Thailand Fund – Senior Research Scholar Program

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Fauci AS, Johnston MI, Dieffenbach CW et al (2008) HIV vaccine research: the way forward. Science 321:530–532

    Article  PubMed  CAS  Google Scholar 

  2. Haase AT (2010) Targeting early infection to prevent HIV-1 mucosal transmission. Nature 464:217–223

    Article  PubMed  CAS  Google Scholar 

  3. Virgin HW, Wherry EJ, Ahmed R (2009) Redefining chronic viral infection. Cell 138:30–50

    Article  PubMed  CAS  Google Scholar 

  4. Centlivre M, Sala M, Wain-Hobson S et al (2007) In HIV-1 pathogenesis the die is cast during primary infection. AIDS 21:1–11

    Article  PubMed  Google Scholar 

  5. McClure HM, Anderson DC, Fultz PN et al (1989) Spectrum of disease in macaque monkeys chronically infected with SIV/SMM. Vet Immunol Immunopathol 21:13–24

    Article  PubMed  CAS  Google Scholar 

  6. Barry AP, Silvestri G, Safrit JT et al (2007) Depletion of CD8+ cells in sooty mangabey monkeys naturally infected with simian immuno-deficiency virus reveals limited role for immune control of virus replication in a natural host species. J Immunol 178:8002–8012

    PubMed  CAS  Google Scholar 

  7. Klatt NR, Villinger F, Bostik P et al (2008) Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys. J Clin Invest 118:2039–2049

    PubMed  CAS  Google Scholar 

  8. Pereira LE, Johnson RP, Ansari AA (2008) Sooty mangabeys and rhesus macaques exhibit significant divergent natural killer cell responses during both acute and chronic phases of SIV infection. Cell Immunol 254:10–19

    Article  PubMed  CAS  Google Scholar 

  9. Powell JD, McClure HM, Anderson D et al (1989) Phenotypic and functional differences in NK and LAK cells in the peripheral blood of sooty mangabeys and rhesus macaques. Cell Immunol 124:107–118

    Article  PubMed  CAS  Google Scholar 

  10. Pereira LE, Ansari AA (2009) A case for innate immune effector mechanisms as contributors to disease resistance in SIV-infected sooty mangabeys. Curr HIV Res 7:12–22

    Article  PubMed  CAS  Google Scholar 

  11. Parikh UM, Dobard C, Sharma S et al (2009) Complete protection from repeated vaginal simian-human immuno-deficiency virus exposures in macaques by a topical gel containing tenofovir alone or with emtricitabine. J Virol 83:10358–10365

    Article  PubMed  CAS  Google Scholar 

  12. Gauduin MC, Yu Y, Barabasz A et al (2006) Induction of a virus-specific effector-memory CD4+ T cell response by attenuated SIV infection. J Exp Med 203:2661–2672

    Article  PubMed  CAS  Google Scholar 

  13. Mori K, Sugimoto C, Ohgimoto S et al (2005) Influence of glycosylation on the efficacy of an Env-based vaccine against simian immuno-deficiency virus SIVmac239 in a macaque AIDS model. J Virol 79:10386–10396

    Article  PubMed  CAS  Google Scholar 

  14. Pandrea I, Onanga R, Souquiere S et al (2008) Paucity of CD4+ CCR5+ T cells may prevent transmission of simian immuno-deficiency virus in natural nonhuman primate hosts by breast-feeding. J Virol 82:5501–5509

    Article  PubMed  CAS  Google Scholar 

  15. Webster RL, Johnson RP (2005) Delineation of multiple sub-populations of natural killer cells in rhesus macaques. Immunology 115:206–214

    Article  PubMed  CAS  Google Scholar 

  16. DeNucci CC, Pagan AJ, Mitchell JS et al (2010) Control of alpha4beta7 integrin expression and CD4 T cell homing by the beta1 integrin sub-unit. J Immunol 184:2458–2467

    Article  PubMed  CAS  Google Scholar 

  17. Kwak-Kim J, Park JC, Ahn HK et al (2010) Immunological modes of pregnancy loss. Am J Reprod Immunol 63:611–623

    Google Scholar 

  18. Yagel S (2009) The developmental role of natural killer cells at the fetal-maternal interface. Am J Obstet Gynecol 201:344–350

    Article  PubMed  CAS  Google Scholar 

  19. Colonna M (2009) Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity. Immunity 31:15–23

    Article  PubMed  CAS  Google Scholar 

  20. Bostik P, Kobkitjaroen J, Tang W et al (2009) Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in simian immuno-deficiency virus-infected rhesus macaques with high viral loads. J Immunol 182:3638–3649

    Article  PubMed  CAS  Google Scholar 

  21. Fellay J, Ge D, Shianna KV et al (2009) Common genetic variation and the control of HIV-1 in humans. PLoS Genet 5:e1000791

    Article  PubMed  Google Scholar 

  22. Carrington M, O’Brien SJ (2003) The influence of HLA genotype on AIDS. Annu Rev Med 54:535–551

    Article  PubMed  CAS  Google Scholar 

  23. Kaslow RA, Carrington M, Apple R et al (1996) Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection. Nat Med 2:405–411

    Article  PubMed  CAS  Google Scholar 

  24. Migueles SA, Sabbaghian MS, Shupert WL et al (2000) HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors. Proc Natl Acad Sci USA 97:2709–2714

    Article  PubMed  CAS  Google Scholar 

  25. Herbeck JT, Gottlieb GS, Winkler CA et al (2010) Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS. J Infect Dis 201:618–626

    Article  PubMed  CAS  Google Scholar 

  26. Alter G, Altfeld M (2009) NK cells in HIV-1 infection: evidence for their role in the control of HIV-1 infection. J Intern Med 265:29–42

    Article  PubMed  CAS  Google Scholar 

  27. Alter G, Rihn S, Walter K et al (2009) HLA class I subtype-dependent expansion of KIR3DS1+ and KIR3DL1+ NK cells during acute human immuno-deficiency virus type 1 infection. J Virol 83:6798–6805

    Article  PubMed  CAS  Google Scholar 

  28. Martin MP, Gao X, Lee JH et al (2002) Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet 31:429–434

    PubMed  CAS  Google Scholar 

  29. Martin MP, Qi Y, Gao X et al (2007) Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat Genet 39:733–740

    Article  PubMed  CAS  Google Scholar 

  30. Hershberger KL, Shyam R, Miura A et al (2001) Diversity of the killer cell Ig-like receptors of rhesus monkeys. J Immunol 166:4380–4390

    PubMed  CAS  Google Scholar 

  31. Cadavid LF, Lun CM (2009) Lineage-specific diversification of killer cell Ig-like receptors in the owl monkey, a new world primate. Immunogenetics 61:27–41

    Article  PubMed  CAS  Google Scholar 

  32. Guethlein LA, Flodin LR, Adams EJ et al (2002) NK cell receptors of the orangutan (Pongo pygmaeus): a pivotal species for tracking the co-evolution of killer cell Ig-like receptors with MHC-C. J Immunol 169:220–229

    PubMed  CAS  Google Scholar 

  33. Hershberger KL, Kurian J, Korber BT et al (2005) Killer cell immunoglobulin-like receptors (KIR) of the African-origin sabaeus monkey: evidence for recombination events in the evolution of KIR. Eur J Immunol 35:922–935

    Article  PubMed  CAS  Google Scholar 

  34. Sambrook JG, Beck S (2007) Evolutionary vignettes of natural killer cell receptors. Curr Opin Immunol 19:553–560

    Article  PubMed  CAS  Google Scholar 

  35. Bimber BN, Moreland AJ, Wiseman RW et al (2008) Complete characterization of killer Ig-like receptor (KIR) haplotypes in Mauritian cynomolgus macaques: novel insights into nonhuman primate KIR gene content and organization. J Immunol 181:6301–6308

    PubMed  CAS  Google Scholar 

  36. Chaichompoo P, Bostik P, Stephenson S et al (2010) Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV infected rhesus macaques. Cell Immunol 263:176–187

    Google Scholar 

  37. Blokhuis JH, van der Wiel MK, Doxiadis GG et al (2010) The mosaic of KIR haplotypes in rhesus macaques. Immunogenetics 62:295–306

    Article  PubMed  Google Scholar 

  38. Kruse PH, Rosner C, Walter L (2010) Characterization of rhesus macaque KIR genotypes and haplotypes. Immunogenetics 62:281–293

    Article  PubMed  Google Scholar 

  39. David G, Morvan M, Gagne K et al (2009) Discrimination between the main activating and inhibitory killer cell immunoglobulin-like receptor positive natural killer cell subsets using newly characterized monoclonal antibodies. Immunology 128:172–184

    Article  PubMed  CAS  Google Scholar 

  40. Tripathi P, Agrawal S (2007) The role of human leukocyte antigen E and G in HIV infection. AIDS 21:1395–1404

    Article  PubMed  Google Scholar 

  41. Dong Y, Lieskovska J, Kedrin D et al (2003) Soluble non-classical HLA generated by the metalloproteinase pathway. Hum Immunol 64:802–810

    Article  PubMed  CAS  Google Scholar 

  42. Liu Q, Sun Y, Rihn S et al (2009) Matrix metalloprotease inhibitors restore impaired NK cell-mediated antibody-dependent cellular cytotoxicity in human immuno-deficiency virus type 1 infection. J Virol 83:8705–8712

    Article  PubMed  CAS  Google Scholar 

  43. Kumagai Y, Akira S (2010) Identification and functions of pattern-recognition receptors. J Allergy Clin Immunol 125:985–992

    Article  PubMed  CAS  Google Scholar 

  44. Cooper MA, Colonna M, Yokoyama WM (2009) Hidden talents of natural killers: NK cells in innate and adaptive immunity. EMBO Rep 10:1103–1110

    Article  PubMed  CAS  Google Scholar 

  45. Cooper MA, Elliott JM, Keyel PA et al (2009) Cytokine-induced memory-like natural killer cells. Proc Natl Acad Sci USA 106:1915–1919

    Article  PubMed  CAS  Google Scholar 

  46. O’Leary JG, Goodarzi M, Drayton DL et al (2006) T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat Immunol 7:507–516

    Article  PubMed  Google Scholar 

  47. Sun JC, Beilke JN, Lanier LL (2009) Adaptive immune features of natural killer cells. Nature 457:557–561

    Article  PubMed  CAS  Google Scholar 

  48. Sun JC, Lanier LL (2009) Natural killer cells remember: an evolutionary bridge between innate and adaptive immunity? Eur J Immunol 39:2059–2064

    Article  PubMed  CAS  Google Scholar 

  49. Lu L, Ikizawa K, Hu D et al (2007) Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity 26:593–604

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

The authors are grateful to Ms. Stephanie Ehnert and her staff at the Yerkes National Primate Center for their outstanding help in conducting the studies that are summarized in this report. In addition, the authors would like to acknowledge support by the National Institutes of Health RO1 AI078773, the Thailand Research Fund Senior Scholars Program and the Yerkes Base grant DRR-00165. The technical assistance of Dr. Susan T. Stephenson and Ms. Dawn Little is gratefully acknowledged.

Author information

Authors and Affiliations

  1. Department of Pathology, Emory University School of Medicine, Room 2309 WMB, 101 Woodruff Circle, Atlanta, GA, 30322, USA

    Aftab A. Ansari

Authors
  1. Aftab A. Ansari
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ann E. Mayne
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yoshiaki Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kovit Pattanapanyasat
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Aftab A. Ansari .

Editor information

Editors and Affiliations

  1. Emory Vaccine Center &, Yerkes National Primate Research Center, Emory University, Gatewood Rd. 954, Atlanta, 30329, Georgia, USA

    Bali Pulendran

  2. College of Medicine, Department Microbiology & Immunology, Drexel University, Queen Lane 2900, Philadelphia, 19129, Pennsylvania, USA

    Peter D. Katsikis

  3. , Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immun, Athena Circle 9420, La Jolla, 92037, USA

    Stephen P. Schoenberger

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Businees Media, LLC

About this paper

Cite this paper

Ansari, A.A., Mayne, A.E., Takahashi, Y., Pattanapanyasat, K. (2011). Incorporation of Innate Immune Effector Mechanisms in the Formulation of a Vaccine Against HIV-1. In: Pulendran, B., Katsikis, P., Schoenberger, S. (eds) Crossroads between Innate and Adaptive Immunity III. Advances in Experimental Medicine and Biology, vol 780. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5632-3_12

Download citation

Publish with us

Policies and ethics

Search

Navigation