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Oxygen Transport to Tissue XXXI pp 285–291Cite as

Modelling of Mitochondrial Oxygen Consumption and NIRS Detection of Cytochrome Oxidase Redox State

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 662))

Abstract

In recent years there has been widespread use of near infrared spectroscopy (NIRS) to monitor the brain. The signals of interest include changes in the levels of oxygenated and deoxygenated haemoglobin and tissue oxygen saturation. In addition to oxy- and deoxy-haemoglobin, the CuA centre in cytochrome-c-oxidase (CCO) is a significant NIR absorber, giving rise to another signal termed the ΔoxCCO signal. This signal has great potential as a marker of cellular oxygen metabolism, but is also the hardest to interpret. Here we use a recently constructed model to predict NIRS signal changes, and compare the model output to data from an in vivo hypoxia study in healthy adults. Our findings indicate strongly that the ΔoxCCO signal contains useful information despite the noise, and has responses consistent with the known physiology.

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Author information

Authors and Affiliations

  1. Department of Biological Sciences, University of Essex, Colchester, CO4 3SQ, UK

    Murad Banaji & Peter Nicholls

  2. Department of Medical Physics and Bioengineering, University College London, Gower St., London, WC1E 6BT, UK

    Alfred Mallet

  3. Biomedical Optics Research Laboratory, Department of Medical Physics and Bioengineering, University College London, Gower Street, London, WC1E 6BT, UK

    Clare E. Elwell & Ilias Tachtsidis

  4. Department of Biological Sciences, Great Ormond Street Hospital for Children, London, WC1N 3JH, UK

    Martin Smith

  5. Department of Biological Sciences, Centre for Sports and Exercise Science, University of Essex, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UK

    Chris E. Cooper

Authors
  1. Murad Banaji
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  2. Alfred Mallet
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  3. Clare E. Elwell
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  4. Peter Nicholls
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  5. Ilias Tachtsidis
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  6. Martin Smith
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  7. Chris E. Cooper
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Corresponding author

Correspondence to Chris E. Cooper .

Editor information

Editors and Affiliations

  1. School of Medicine, Yamagata University, Yamagata, 990-9585, Japan

    Eiji Takahashi

  2. Westminster Rd 2773, Ellicott City, 21043, U.S.A.

    Duane F. Bruley

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Banaji, M. et al. (2010). Modelling of Mitochondrial Oxygen Consumption and NIRS Detection of Cytochrome Oxidase Redox State. In: Takahashi, E., Bruley, D. (eds) Oxygen Transport to Tissue XXXI. Advances in Experimental Medicine and Biology, vol 662. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-1241-1_41

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