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Adrenocortical Carcinoma

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Endocrine Neoplasia

Part of the book series: Cancer Treatment and Research ((CTAR,volume 153))

Abstract

Adrenal tumors are common, with an estimated incidence of 7.3% from autopsy series [1]. A recent study found an overall 4.4% prevalence of incidental adrenal lesions by computed tomography (CT) [2]. The majority are benign adrenocortical adenomas. Adrenocortical carcinoma (ACC), however, is rare with an estimated prevalence of only 4–12/million population [3]. Histopathology does not always accurately predict malignancy in adrenal tumors. The prognosis for ACCs is poor with an overall 5-year survival of <40% [4,5]. Complete en-bloc, margin-negative (R0) resection is the best treatment. Adjuvant treatment options for ACCs are fairly limited. The dismal survival rates for ACC have remained unchanged over the last 20 years. Advancement in the understanding of the pathophysiology of ACC is therefore essential for the development of more sensitive means of diagnosis and more effective treatment, resulting in better clinical outcome.

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Authors and Affiliations

  1. Kolling Institute of Medical Research, University of Sydney, Sydney, NSW, Australia

    Stan B. Sidhu

  2. Department of Endocrine and Oncology Surgery, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia

    Stan B. Sidhu

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  1. Patsy S. H. Soon
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  2. Stan B. Sidhu
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Correspondence to Stan B. Sidhu .

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  1. Feinberg School of Medicine, Northwestern University, E. Huron St. 201, Chicago, 60611, U.S.A.

    Cord Sturgeon

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Soon, P.S.H., Sidhu, S.B. (2010). Adrenocortical Carcinoma. In: Sturgeon, C. (eds) Endocrine Neoplasia. Cancer Treatment and Research, vol 153. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0857-5_11

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