Abstract
Data sharing represents one of the key objectives and major challenges of today’s cancer research. CancerGrid, a consortium of clinicians, cancer researchers, computational biologists and software engineers from leading UK institutions, is developing open-standards cancer informatics addressing this challenge. The CancerGrid solution involves the representation of a widely accepted clinical trials model in controlled vocabulary and common data elements (CDEs) as the enabling factor for cancer data sharing. This paper describes a cancer data query system that supports data sharing across CancerGrid-compliant clinical trial boundaries. The formal specification of the query system allows the model-driven development of a flexible, web-based interface that cancer researchers with limited IT experience can use to identify and query common data across multiple clinical trials.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
James Brenton, Carlos Caldas, Jim Davies, Steve Harris and Peter Maccallum, “CancerGrid: developing open standards for clinical cancer informatics”, Proceedings of the UK e-Science All Hands Meeting 2005, pp. 678-681, underline http://www.allhands.org.uk/2005/proceedings/.
Steve Harris and Radu Calinescu, “Clinical trials model 1.0”, CancerGrid Technical Report MRC/1.4.1.1, June 2006, underline http://www.cancergrid.org/ public/documents/2006/mrc/Report%20MRC-1.4.1.1%20Clinical%20 trials%20model%201.0.pdf.
Igor Toujilov and Peter Maccallum, “Common data element management architecture”, CancerGrid Technical Report MRC-1.1.2, May 2006, underline http://www.cancergrid.org/public/documents/2006/mrc/Report%20MRC-1.1.2%20CDE%20management%20architecture.pdf.
Radu Calinescu, “Model-based SOA generation for cancer clinical trials”, Best Practices and Methodologies in Service-Oriented Architectures – Proceedings of the 4th OOPSLA International Workshop on SOA and Web Services, Portland, October 2006, pp. 57-71.
Jim Woodcock and Jim Davies, “Using Z. Specification, Refinement and Proof", Prentice Hall, 1996.
Yigal Arens, Chin Y. Chee, Chun-Nan Hsu and Craig A. KnoBlock, “Retrieving and Integrating Data from Multiple Information Sources”, Journal of Intelligent and Cooperative Information Systems, vol. 2, no. 2, June 1993, pp. 127-158.
Waiman Cheung and Cheng Hsu, “The Model-Assisted Global Query System for Multiple Databases in Distributed Enterprises”, ACM Transactions on Information Systems, vol. 14, no. 4, October 1996, pp. 421–470.
Silvana Castano, Valeria De Antonellis and Sabrina De Capitani di Vimercati, “Global Viewing of Heterogeneous Data Sources”, IEEE Transactions on Knowledge and Data Engineering, vol. 13, no. 2, March/April 2001, pp. 277-297.
US National Cancer Institute, The cancer Biomedical Informatics Grid, 2006, underline https://cabig.nci.nih.gov/.
Rebecca Kush, “Can the Protocol be Standardised?”, Clinical Data Interchange Standards Consortium, 2006, underline http://www.cdisc.org/ publications/CDISK_ed.pdf.
Peter A. Covitz, Frank Hartel, Carl Schaefer, Sherri De Corondao, Gilberto Fragoso, Himanso Sahni et al., “caCORE: A common infrastructure for cancer informatics”, Bioinformatics, vol. 19, no. 18, pp. 2404-2412, 2003, underline http://bioinformatics.oxfordjournals.org/cgi/content/ abstract/19/18/2404.
Anthony Stell, Richard Sinnott and Oluwafemi Ajayi, “Supporting the Clinical Trial Recruitment Process through the Grid”, Proceedings of the UK e-Science All Hands Meeting 2006, pp. 61-68.
Gao Cong, Wenfei Fan, Xibei Jia and Shuai Ma, “PRATA: A System for XML Publishing, Integration and View Maintenance”, Proceedings of the UK e-Science All Hands Meeting 2006, pp. 432-435.
Chris Poole, Helen Howard and Janet Dunn, “tAnGo - a randomised phase III trial of gemcitabine in paclitaxel-containing, epirubicin-based, adjuvant chemotherapy for women with early stage breast cancer”, 2003, underline http://www.isdscotland.org/isd/files/tAnGo_protocol_version_2.0_July_2003.pdf.
Elaine Beller, Val Gebski and Anthony Keech, “Randomisation in clinical trials”, Medical Journal of Australia, vol. 177, Nov. 2002, pp. 565-567, http://www.mja.com.au/public/issues/177_10_181102/bel10697_fm.pdf.
Earl H M, Poole C J, Dunn J A, Hiller L, Bathers S, Spooner D et al, “NEAT - National Epirubicin Adjuvant Trial, a multi-centre phase III randomised trial of Epirubicin x 4 and classical CMFx4 [ECMF] versus CMFx6”, Proceedings of the American Society of Clinical Oncology 21 (2), 2002, pp. 1081-0641.
Bill Evjen, Scott Hanselman, Farhan Muhammad, Srinivasa Sivakumar and Devin Rader, Professional ASP.NET 2.0, Wiley Publishing, 2006.
D.F.Ferraiolo, D.R.Kuhn and R.Chandramouli, Role-Based Access Control, Computer Security Series, Artech House, 2003.
David F. Ferraiolo, Ravi Sandhu, Serban Gavrila, D. Richard Kuhn and Ramaswamy Chandramouli, “Proposed NIST standard for role-based access control”, ACM Transactions on Information and System Security, 4(3), pp. 224–274, August 2001, http://csrc.nist.gov/rbac/rbacSTD-ACM.pdf.
V. Haarslev and R. Moller, “Racer system description”, Proceedings of the First International Joint Conference on Automated Reasoning, Lecture Notes in Computer Science, vol. 2083, Springer-Verlag, 2001, pp. 701-706.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer
About this paper
Cite this paper
Calinescu, R., Harris, S., Gibbons, J., Davies, J. (2007). Cross-Trial Query System for Cancer Clinical Trials. In: Sobh, T. (eds) Innovations and Advanced Techniques in Computer and Information Sciences and Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6268-1_69
Download citation
DOI: https://doi.org/10.1007/978-1-4020-6268-1_69
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-6267-4
Online ISBN: 978-1-4020-6268-1
eBook Packages: EngineeringEngineering (R0)