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Brain Banking in Dementia Studies

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Biomarkers for Alzheimer’s Disease Drug Development

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2785))

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Abstract

It is now well-established practice in dementia that one clinical entity may be caused by various neurodegenerative disorders, each with different histopathological findings, whereas neuropathologically confirmed patients may have different, unusual, and atypical clinical manifestations.

This inconsistency in dementia patients leads to neuropathological examination of cases, and neuropathological examination seems to be an inevitable part of dementia practice, at least until all clinical entities are properly identified for humans.

Additionally, the development of disease-modifying therapies and confirmation of the actual accurate diagnosis of the neurodegenerative disease that the drug is thought to modify or act upon are of great importance for neuropathological evaluation in brain banks.

Neuropathological processes coexisting among patients diagnosed with established clinical criteria or international guidelines have provided a new perspective in the context of drug development.

Here, we review our routinely used methodology in the context of the brain banking process.

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References

  1. Dedova I, Harding A, Sheedy D, Garrick T, Sundqvist N, Hunt C, Gillies J, Harper CG (2009) The importance of brain banks for molecular neuropathological research: The New South Wales Tissue Resource Centre experience. Int J Mol Sci 10:366–384

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Teacher JH (1900) Catalogue of the anatomical and pathological preparations of Dr William Hunter. James MacLehose and Sons, Hunterian Museum, Glasgow, pp 318–319

    Google Scholar 

  3. Gere C (2005) History of neuroscience: a brief history of brain archiving. IBRO History of neuroscience

    Google Scholar 

  4. Nosographie philosophique, ou la méthode de l’analyse appliquée à la médecine (2 volumes) (1798)

    Google Scholar 

  5. Alzheimer A (1907) Über eine eigenartige Erkrankung der Hirnrinde. Allg Zschr Psychiatr Psych gerichtl Med 64:146–148

    Google Scholar 

  6. Isik AT, Danyeli AE, Kaya D, Soysal P, Karabay N, Gokden M (2020) The importance of brain banking for dementia practice: the first experience of Turkey. Cell Tissue Bank 21:367–375

    Article  PubMed  Google Scholar 

  7. Vonsattel JPG, del Amaya MP, Keller CE (2008) Twenty-first century brain banking. Processing brains for research: the Columbia University methods. Acta Neuropathol 115:509–532

    Article  PubMed  Google Scholar 

  8. Poloni TE, Medici V, Carlos AF, Davin A, Ceretti A, Mangieri M, Cassini P, Vaccaro R, Zaccaria D, Abbondanza S, Bordoni M, Fantini V, Fogato E, Cereda C, Ceroni M, Guaita A (2020) Abbiategrasso brain bank protocol for collecting, processing and characterizing aging brains. J Vis Exp 160(e60296):1–25

    Google Scholar 

  9. Waldvogel HJ, Curtis MA, Baer K, Rees MI, Faull RLM (2006) Immunohistochemical staining of post-mortem adult human brain sections. Nat Protoc 1:2719–2732

    Article  CAS  PubMed  Google Scholar 

  10. Grinberg LT, de Lucena Ferretti RE, Farfel JM, Leite R, Pasqualucci CA, Rosemberg S, Nitrini R, Saldiva PHN, Filho WJ, Brazilian Aging Brain Study Group (2007) Brain bank of the Brazilian aging brain study group – a milestone reached and more than 1,600 collected brains. Cell Tissue Bank 8:151–162

    Article  PubMed  Google Scholar 

  11. Cairns NJ, Taylor-Reinwalda L, Morrisa JC, and the Alzheimer’s Disease Neuroimaging Initiative (2010) Autopsy consent, brain collection, and standardized neuropathologic assessment of ADNI participants: the essential role of the neuropathology core. Alzheimers Dement 6:274–279

    Article  PubMed  Google Scholar 

  12. Beach TG, Adler CH, Sue LI, Serrano G, Shill HA, Walker DG, Lue LF, Roher AE, Dugger BN, Maarouf C, Birdsill AC, Intorcia A, Saxon-Labelle M, Pullen J, Scroggins A, Filon J, Scott S, Hoffman B, Garcia A, Caviness JN, Hentz JG, Driver-Dunckley E, Jacobson SA, Davis KJ, Belden CM, Long KE, Malek-Ahmadi M, Powell JJ, Gale LD, Nicholson LR, Caselli RJ, Woodruff BK, Rapscak SZ, Ahern GL, Shi J, Burke AD, Reiman EM, Sabbagh MN (2015) Arizona study of aging and neurodegenerative disorders and brain and body donation program. Neuropathology 35:354–389

    Article  PubMed  PubMed Central  Google Scholar 

  13. Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, Hyman BT, Jellinger K, Jicha GA, Kovacs GG, Knopman DS, Kofler J, Kukull WA, Mackenzie IR, Masliah E, McKee A, Montine TJ, Murray ME, Neltner JH, Santa-Maria I, Seeley WW, Serrano-Pozo A, Shelanski ML, Stein T, Takao M, Thal DR, Toledo JB, Troncoso JC, Vonsattel JP, White CL 3rd, Wisniewski T, Woltjer RL, Yamada M, Nelson PT (2014) Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol 128:755–766

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Cykowski MD, Powell SZ, Schulz PE, Takei H, Rivera AL, Jackson RE, Roman G, Jicha GA, Nelson PT (2017) Hippocampal sclerosis in older patients: practical examples and guidance with a focus on cerebral age-related TDP-43 with sclerosis. Arch Pathol Lab Med 141:1113–1126

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Nelson PT, Dickson DW, Trojanowski JQ, Jack CR Jr, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Chui HC, Fardo DW, Flanagan ME, Halliday G, Hokkanen SRK, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murayama S, Murray ME, Nag S, Rissman RA, Seeley WW, Sperling RA, White CL III, Yu L, Schneider JA (2019) Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain 142:1503–1527

    Article  PubMed  PubMed Central  Google Scholar 

  16. Peden AH, Kanguru L, Ritchie DL, Smith C, Molesworth AM (2019) Study protocol for enhanced CJD surveillance in the 65+ years population group in Scotland: an observational neuropathological screening study of banked brain tissue donations for evidence of prion disease. BMJ Open 9(10):e033744

    Article  PubMed  PubMed Central  Google Scholar 

  17. Nelson PT, Trojanowski JQ, Abner EL, Al-Janabi OM, Jicha GA, Schmitt FA, Smith CD, Fardo DW, Wang WX, Kryscio RJ, Neltner JH, Kukull WA, Cykowski MD, Van Eldik LJ, Ighodaro ET (2016) “New old pathologies”: AD, PART, and cerebral age-related TDP-43 with sclerosis (CARTS). J Neuropathol Exp Neurol 75:482–498

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Hatanpaa KJ, Raisanen JM, Herndon E, Burns DK, Foong C, Habib AA, White CL III (2014) Hippocampal sclerosis in dementia, epilepsy, and ischemic injury: differential vulnerability of hippocampal subfields. J Neuropathol Exp Neurol 73:136–142

    Article  CAS  PubMed  Google Scholar 

  19. Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Trojanowski JQ, Vinters HJ, Hyman BT (2012) National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach. Acta Neuropathol 123:1–11

    Article  CAS  PubMed  Google Scholar 

  20. Thal DR, Rüb U, Orantes M, Braak H (2002) Phases of Aβ-deposition in the human brain and its relevance for the development of AD. Neurology 58:1791–1800

    Article  PubMed  Google Scholar 

  21. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L (1991) The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer’s disease. Neurology 41:479–486

    Article  CAS  PubMed  Google Scholar 

  22. Braak H, Braak E (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 82:239–259

    Article  CAS  PubMed  Google Scholar 

  23. Mackenzie IR, Neumann M, Bigio EH, Cairns NJ, Alafuzoff I, Kril J, Kovacs GG, Ghetti B, Halliday G, Holm IE, Ince PG, Kamphorst W, Revesz T, Rozemuller AJM, Kumar-Singh S, Akiyama H, Baborie A, Spina S, Dickson DW, Trojanowski JQ, Mann DMA (2010) Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol 119:1–4

    Article  PubMed  Google Scholar 

  24. McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, VMY L, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M, Consortium on DLB (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium. Neurology 65:1863–1872

    Article  CAS  PubMed  Google Scholar 

  25. Greenberg SM, Charidimou A (2018) Diagnosis of cerebral amyloid AngiopathyEvolution of the Boston criteria. Stroke 49:491–497

    Article  PubMed  PubMed Central  Google Scholar 

  26. Smallwood A, Oulhaj A, Joachim C, Christie S, Sloan C, Smith AD, Esiri M (2012) Cerebral subcortical small vessel disease and its relation to cognition in elderly subjects: a pathological study in the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort. Neuropathol Appl Neurobiol 38:337–343

    Article  CAS  PubMed  Google Scholar 

  27. Love S, Miners SJ (2015) White matter hypoperfusion and damage in dementia: post-mortem assessment. Brain Pathol 25:99–107

    Article  PubMed  Google Scholar 

  28. Murphy DD, Ravina B (2003) Brain banking for neurodegenerative diseases. Curr Opin Neurol 16:459–463

    Article  PubMed  Google Scholar 

  29. Nelson PT, Jicha GA, Kryscio RJ, Abner EL, Schmitt FA, Cooper G, Xu LO, Smith CD, Markesbery WR (2010) Low sensitivity in clinical diagnoses of dementia with Lewy bodies. J Neurol 257:359–366

    Article  PubMed  Google Scholar 

  30. Franklin EE, Perrin RJ, Vincent B, Baxter M, Morris JC, Cairns NJ (2015) Brain collection, standardized neuropathologic assessment, and comorbidity in ADNI participants. Alzheimers Dement 11:815–822

    Article  PubMed  Google Scholar 

  31. Thomas AJ, Taylor JP, McKeith I, Bamford C, Burn D, Allan L, O’Brien J (2017) Development of assessment toolkits for improving the diagnosis of the Lewy body dementias: feasibility study within the DIAMOND Lewy study. Int J Geriatr Psychiatry 32:1280–1304

    Article  PubMed  Google Scholar 

  32. Cummings J, Feldman HH, Scheltens P (2019) The “rights” of precision drug development for Alzheimer’s disease. Alzheimers Res Ther 11:76

    Article  PubMed  PubMed Central  Google Scholar 

  33. Cummings J (2018) Lessons learned from Alzheimer disease: clinical trials with negative outcomes. Clin Transl Sci 11:147–152

    Article  PubMed  Google Scholar 

  34. Rabinovici GD, Carrillo MC, Forman M, DeSanti S, Miller DS, Kozauer N, Petersen RC, Randolph C, Knopman DS, Smith EE, Isaac M, Mattsson N, Bain LJ, Hendrix JA, Sims JR (2016) Multiple comorbid neuropathologies in the setting of Alzheimer’s disease neuropathology and implications for drug development. Alzheimers Dement (N Y) 3:83–91

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Unit for Aging Brain and Dementia, Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

    Ahmet Turan Isik & Derya Kaya

  2. Division of Neuropathology, Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Murat Gokden

Authors
  1. Ahmet Turan Isik
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  2. Derya Kaya
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  3. Murat Gokden
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Editors and Affiliations

  1. Department of Psychiatry and Psychotherapy, LMU Klinikum, München, Germany

    Robert Perneczky

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© 2024 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Isik, A.T., Kaya, D., Gokden, M. (2024). Brain Banking in Dementia Studies. In: Perneczky, R. (eds) Biomarkers for Alzheimer’s Disease Drug Development. Methods in Molecular Biology, vol 2785. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3774-6_17

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  • DOI: https://doi.org/10.1007/978-1-0716-3774-6_17

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3773-9

  • Online ISBN: 978-1-0716-3774-6

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