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Circulating Non-coding RNAs and Exosomes: Liquid Biopsies for Monitoring Preeclampsia

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Liquid Biopsies

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2695))

Abstract

Preeclampsia (PE) remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the lack of clarity on the etiology of the disorder. The early prediction or accurate diagnosis of PE is a concern of researchers. Liquid biopsy can be analyzed for cell-free nucleic acids and exosomes. Because circulating non-coding RNAs (ncRNAs) and peripheral blood exosomes can be detected in the peripheral blood of women in early pregnancy, these vesicles and their contents have become the focus of research on early predictive and diagnostic biomarkers for preeclampsia. In this review, we focus on recent studies addressing the roles of circulating ncRNAs and exosomes in PE, with particular attention paid to the potential application value of placenta-derived exosomes and circulating ncRNAs as PE-specific biomarkers.

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Acknowledgments

The present study was funded by Wuxi Commission of Health and Family Planning (Grant No.: Q202104), Key Project of Maternal and Child Health of Jiangsu Province (Grant No.: F2022107) and the Wuxi Taihu Talent Project Fund (2021 No.19). Na Li and Ying Gu contributed equally to this work.

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Authors and Affiliations

  1. Lab of Perinatal Medicine, Wuxi Maternity and Child Health Care Hospital, Wuxi, Jiangsu, China

    Na Li, Ying Gu, Daozhen Chen & Zhice Xu

  2. Institute for Fetology, First Hospital of Soochow University, Suzhou, China

    Jiaqi Tang

  3. Department of Obstetrics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China

    Yongmei Li

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  1. Na Li
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  2. Ying Gu
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  3. Jiaqi Tang
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  4. Yongmei Li
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  5. Daozhen Chen
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  6. Zhice Xu
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  1. CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China

    Tao Huang

  2. Geneis Beijing Co. Ltd., Beijing, China

    Jialiang Yang

  3. Geneis Beijing Co. Ltd., Beijing, China

    Geng Tian

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Li, N., Gu, Y., Tang, J., Li, Y., Chen, D., Xu, Z. (2023). Circulating Non-coding RNAs and Exosomes: Liquid Biopsies for Monitoring Preeclampsia. In: Huang, T., Yang, J., Tian, G. (eds) Liquid Biopsies. Methods in Molecular Biology, vol 2695. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3346-5_18

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  • DOI: https://doi.org/10.1007/978-1-0716-3346-5_18

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