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Modeling of Olfactory Receptors

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Homology Modeling

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2627))

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Abstract

Olfactory receptors (ORs) form the largest subfamily within class A G protein-coupled receptors (GPCRs). No experimental structural data of any OR is available to date. Homology modeling has become a popular strategy to propose plausible OR models, in order to study the structure-function relationships of the receptors and to aid the discovery and development of ligands capable of modulating receptor activity. In this chapter, we provide a general guideline for OR structure construction, including the collection of candidate templates, structure-based sequence alignment, 3D structure construction, ligand docking, and molecular dynamic simulation.

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Authors and Affiliations

  1. Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, Shenzhen, China

    Xueying Wang, H. C. Stephen Chan & Shuguang Yuan

Authors
  1. Xueying Wang
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  2. H. C. Stephen Chan
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  3. Shuguang Yuan
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Corresponding author

Correspondence to Shuguang Yuan .

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Editors and Affiliations

  1. Faculty of Chemistry, University of Warsaw, Warsaw, Poland

    SÅ‚awomir Filipek

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Wang, X., Stephen Chan, H.C., Yuan, S. (2023). Modeling of Olfactory Receptors. In: Filipek, S. (eds) Homology Modeling. Methods in Molecular Biology, vol 2627. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2974-1_10

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  • DOI: https://doi.org/10.1007/978-1-0716-2974-1_10

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2973-4

  • Online ISBN: 978-1-0716-2974-1

  • eBook Packages: Springer Protocols

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