Abstract
Fine-needle aspiration biopsy is the most common method for preoperative diagnosis of thyroid carcinomas including papillary carcinoma. The procedure is best performed with ultrasound by operator with professional skill and knowledge. Several guidelines recommend the indication of fine-needle aspiration concerning the pattern of ultrasound and size of nodules. Besides, fine-needle aspiration biopsy of lymph nodes should be performed if malignancies are suspected. Fine-needle aspiration biopsy of thyroid gland is mostly safe, but complications such as blood extravasation-related complications, acute thyroid enlargement, infection in thyroid gland, and pneumothorax could occur. The most frequent complications are blood extravasation-related complications, which could be fatal. Similarly, acute thyroid enlargement could also be severe. To conclude, fine-needle aspiration biopsy is useful and should be performed under the precise indication and the updated knowledge of complications including the way of handling if they occur.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Singh Ospina N, Brito JP, Maraka S, Espinosa de Ycaza AE, Rodriguez-Gutierrez R, Gionfriddo MR, Castaneda-Guarderas A, Benkhadra K, Al Nofal A, Erwin P, Morris JC, Castro MR, Montori VM (2016) Diagnostic accuracy of ultrasound-guided fine needle aspiration biopsy for thyroid malignancy: systematic review and meta-analysis. Endocrine 53:651–661
Melany M, Chen S (2017) Thyroid cancer: ultrasound imaging and fine-needle aspiration biopsy. Endocrinol Metab Clin N Am 46:691–711
Jiang HJ, Hsiao PJ (2020) Clinical application of the ultrasound-guided fine needle aspiration for thyroglobulin measurement to diagnose lymph node metastasis from differentiated thyroid carcinoma-literature review. Kaohsiung J Med Sci 36:236–243
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L (2016) 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 26:1–133
Gharib H, Papini E, Garber JR, Duick DS, Harrell RM, Hegedüs L, Paschke R, Valcavi R, Vitti P, AACE/ACE/AME Task Force on Thyroid Nodules (2016) American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules-2016 update. Endocr Pract 22:622–639
Tessler FN, Middleton WD, Grant EG, Hoang JK, Berland LL, Teefey SA, Cronan JJ, Beland MD, Desser TS, Frates MC, Hammers LW, Hamper UM, Langer JE, Reading CC, Scoutt LM, Stavros AT (2017) ACR thyroid imaging, reporting and data system (TI-RADS): white paper of the ACR TI-RADS Committee. J Am Coll Radiol 14:587–595
Leenhardt L, Erdogan MF, Hegedus L, Mandel SJ, Paschke R, Rago T, Russ G (2013) 2013 European thyroid association guidelines for cervical ultrasound scans and ultrasound-guided techniques in the postoperative management of patients with thyroid cancer. Eur Thyroid J 2:147–159
Snozek CL, Chambers EP, Reading CC, Sebo TJ, Sistrunk JW, Singh RJ, Grebe SK (2007) Serum thyroglobulin, high-resolution ultrasound, and lymph node thyroglobulin in diagnosis of differentiated thyroid carcinoma nodal metastases. J Clin Endocrinol Metab 92:4278–4281
Polyzos SA, Anastasilakis AD (2010) Systematic review of cases reporting blood extravasation-related complications after thyroid fine-needle biopsy. J Otolaryngol Head Neck Surg 39:532–541
Kakiuchi Y, Idota N, Nakamura M, Ikegaya H (2015) A fatal case of cervical hemorrhage after fine needle aspiration and core needle biopsy of the thyroid gland. Am J Forensic Med Pathol 36:207–209
Strachan MW, Dalvi M, Ainsworth R, Gibb FW, Horsfall H, Patel D (2016) Fatal haemorrhage following fine needle aspiration of the thyroid. J R Coll Physicians Edinb 46:166–167
Covino M, Princi P, De Luca G, Del Ciello A, Simeoni B, Bianchi A, De Crea C, Ojetti V, Raffaelli M, Franceschi F (2020) Spontaneous thyroid nodule hemorrhage in the emergency department. Endocr Pract 26:192–196
Gates C, Newby M, Stokes W, Boo S, Carr M (2020) Embolization of a superior thyroid artery hemorrhage after fine-needle aspiration biopsy of a thyroid nodule. Case Rep Otolaryngol 2020:3727696
Van den Bruel A, Roelandt P, Drijkoningen M, Hudders JP, Decallonne B, Bouillon R (2008) A thyroid thriller: acute transient and symmetric goiter after fine-needle aspiration of a solitary thyroid nodule. Thyroid 18:81–84
Shimo T, Tanaka K, Ogata R, Saito W, Ohta Y, Koike Y, Yamashita T, Yamamoto Y, Kurebayashi J (2014) A case of adenomatous goiter involving diffuse, acute, and painful thyroid enlargement after fine-needle aspiration cytology. Case Rep Endocrinol 2014:284912
Polyzos SA, Anastasilakis AD (2011) Rare potential complications of thyroid fine needle biopsy. Hippokratia 15:116–119
Wu M, Burstein DE (2004) Fine needle aspiration. Cancer Invest 22:620–628
Cesareo R, Naciu A, Barberi A, Pasqualini V, Pelle G, Manfrini S, Tabacco G, Pantano AL, Campagna G, Cianni R, Palermo A (2016) A rare and severe complication following thyroid fine needle aspiration: retropharyngeal cellulitis. Int J Endocrinol Metab 14:e39174
Yldar M, Demirpolat G, Aydin M (2014) Acute suppurative thyroiditis accompanied by thyrotoxicosis after fine-needle aspiration: treatment with catheter drainage. J Clin Diagn Res 8:ND12–14
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature
About this protocol
Cite this protocol
Abe, I., Lam, A.K. (2022). Fine-Needle Aspiration Under Guidance of Ultrasound Examination of Thyroid Lesions. In: Lam, A.K. (eds) Papillary Thyroid Carcinoma. Methods in Molecular Biology, vol 2534. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2505-7_3
Download citation
DOI: https://doi.org/10.1007/978-1-0716-2505-7_3
Published:
Publisher Name: Humana, New York, NY
Print ISBN: 978-1-0716-2504-0
Online ISBN: 978-1-0716-2505-7
eBook Packages: Springer Protocols