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Systems Medicine

  • Book
  • © 2022

Overview

Editors:
  1. Jane P.F. Bai

    1. Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Junguk Hur

    1. School of Medicine and Health Sciences, University of North Dakota, Grand Forks, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2486)

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About this book

This volume explores the latest technological advances and covers all facets of systems medicine with respect to precision medicine. The chapters in this book are organized into four parts. Part One highlights the recent achievements in proteomics for biomarkers identification, integration of omics and phenotypic data for precision medicine, and medicine-guided treatment of drug-induced Stevens-Johnson syndrome. Part Two covers systems-based computational approaches for pharmaceutical research and drug development, the principle of optimizing systemic exposure of drugs, and Animal Rule for drug repurposing. Part Three looks at computational tools and methodologies of network biology, quantitative systems toxicology, and modeling and stimulating patient response variabilities. Part Four talks about how systems medicine can address unmet medical and health needs, and identify educational needs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, Systems Medicine: Methods and Protocols is a valuable resource for the scientific community that will help researchers work together toward the further advancement of achieving the goal of promoting global health.

Chapter 8 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com


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Table of contents (16 protocols)

  1. Front Matter

    Pages i-xiii
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  2. Scientific and Medical Advances

    1. Front Matter

      Pages 1-1
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    2. Mass Spectrometry–Based Proteomics for Biomarker Discovery

      • Zhijun Cao, Li-Rong Yu
      Pages 3-17

    3. Integration of Omics and Phenotypic Data for Precision Medicine

      • Juan Zhao, QiPing Feng, Wei-Qi Wei
      Pages 19-35

    4. Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis in the Era of Systems Medicine

      • Chun-Bing Chen, Chuang-Wei Wang, Wen-Hung Chung
      Pages 37-54

  3. Acceleration of Pharmaceutical Research and Development

    1. Front Matter

      Pages 55-55
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    2. Integration of Engineered Delivery with the Pharmacokinetics of Medical Candidates via Physiology-Based Pharmacokinetics

      • Yuching Yang, Xinyuan Zhang
      Pages 57-69

    3. Applications of Quantitative System Pharmacology Modeling to Model-Informed Drug Development

      • Andy Z. X. Zhu, Mark Rogge
      Pages 71-86

    4. Combating Viral Diseases in the Era of Systems Medicine

      • Jane P. F. Bai, Ellen Y. Guo
      Pages 87-104

    5. Toxicity Analysis of Pentachlorophenol Data with a Bioinformatics Tool Set

      • Natalia Polouliakh, Takeshi Hase, Samik Ghosh, Hiroaki Kitano
      Pages 105-125

  4. Tools and Methodologies

    1. Front Matter

      Pages 127-127
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    2. Virtual Populations for Quantitative Systems Pharmacology Models

      • Yougan Cheng, Ronny Straube, Abed E. Alnaif, Lu Huang, Tarek A. Leil, Brian J. Schmidt
      Pages 129-179Open Access

    3. Quantitative Systems Toxicology and Drug Development: The DILIsym Experience

      • Paul B. Watkins
      Pages 181-196

    4. Introduction to Genomic Network Reconstruction for Cancer Research

      • Guillermo de Anda-Jáuregui, Hugo Tovar, Sergio Alcalá-Corona, Enrique Hernández-Lemus
      Pages 197-214

    5. Learning in Medicine: The Importance of Statistical Thinking

      • Massimiliano Russo, Bruno Scarpa
      Pages 215-232

    6. Development and Applications of Interoperable Biomedical Ontologies for Integrative Data and Knowledge Representation and Multiscale Modeling in Systems Medicine

      • Yongqun He
      Pages 233-244

  5. Systems Medicine to Address Unmet Medical Needs

    1. Front Matter

      Pages 245-245
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    2. Systems Biology to Address Unmet Medical Needs in Neurological Disorders

      • Masha G. Savelieff, Mohamed H. Noureldein, Eva L. Feldman
      Pages 247-276

    3. Informatics in Medical Product Regulation: The Right Drug at the Right Dose for the Right Patient

      • Eileen Navarro Almario, Anna Kettermann, Vaishali Popat
      Pages 277-314

    4. Personal Dense Dynamic Data Clouds Connect Systems Biomedicine to Scientific Wellness

      • Gilbert S. Omenn, Andrew T. Magis, Nathan D. Price, Leroy Hood
      Pages 315-334
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Editors and Affiliations

  • Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, USA

    Jane P.F. Bai

  • School of Medicine and Health Sciences, University of North Dakota, Grand Forks, USA

    Junguk Hur

Bibliographic Information

  • Book Title: Systems Medicine

  • Editors: Jane P.F. Bai, Junguk Hur

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-2265-0

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2022

  • Hardcover ISBN: 978-1-0716-2264-3Published: 19 April 2022

  • Softcover ISBN: 978-1-0716-2267-4Published: 20 April 2023

  • eBook ISBN: 978-1-0716-2265-0Published: 18 April 2022

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XIII, 347

  • Number of Illustrations: 9 b/w illustrations, 59 illustrations in colour

  • Topics: Bioinformatics, Pharmacology/Toxicology, Pharmaceutical Sciences/Technology, Medicine/Public Health, general

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