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Survey of In Vitro Model Systems for Investigation of Key Cellular Processes Associated with Atherosclerosis

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Atherosclerosis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2419))

Abstract

Atherosclerosis progression is associated with a complex array of cellular processes in the arterial wall, including endothelial cell activation/dysfunction, chemokine-driven recruitment of immune cells, differentiation of monocytes to macrophages and their subsequent transformation into lipid laden foam cells, activation of inflammasome and pro-inflammatory signaling, and migration of smooth muscle cells from the media to the intima. The use of in vitro model systems has considerably advanced our understanding of these atherosclerosis-associated processes and they are also often used in drug discovery and other screening platforms. This chapter will describe key in vitro model systems employed frequently in atherosclerosis research.

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Acknowledgments

We thank the British Heart Foundation for financial support (grants PG/16/25/32097 and FS/17/75/33257). AI and FA received PhD studentships from the Kingdom of Saudi Arabia; JC received PhD studentship from China Scholarship Council; and SA received PhD studentship from Oman Government.

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  1. Cardiff School of Biosciences, Cardiff University, Cardiff, UK

    Dipak P. Ramji, Alaa Ismail, Jing Chen, Fahad Alradi & Sulaiman Al Alawi

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  1. Dipak P. Ramji
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  2. Alaa Ismail
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Correspondence to Dipak P. Ramji .

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    Dipak Ramji

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Ramji, D.P., Ismail, A., Chen, J., Alradi, F., Al Alawi, S. (2022). Survey of In Vitro Model Systems for Investigation of Key Cellular Processes Associated with Atherosclerosis. In: Ramji, D. (eds) Atherosclerosis. Methods in Molecular Biology, vol 2419. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1924-7_3

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  • DOI: https://doi.org/10.1007/978-1-0716-1924-7_3

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