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Prepulse Inhibition and Vulnerability to Cocaine Addiction

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Methods for Preclinical Research in Addiction

Part of the book series: Neuromethods ((NM,volume 174))

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Abstract

Prepulse inhibition (PPI) of the startle reflex is the most common sensorimotor gating index, representing the brain’s ability to filter out irrelevant stimuli and prevent information overload. The relationship between PPI impairment and pathology has been widely reported. A PPI deficit is considered an endophenotype of schizophrenia and it is observed in other disorders. Recently, we observed that animals with low PPI are more likely to display behaviors induced by cocaine, which can increase the risk of developing a cocaine use disorder. Therefore, we consider that a PPI deficit could represent a biomarker of vulnerability to the development of a Substance Use Disorder (SUD). The objective of this chapter is to describe PPI, its relation with cocaine addiction and to provide guidelines on how to evaluate it in rodents and humans in order to be able to identify subjects with a PPI deficit.

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Abbreviations

BLA:

Basolateral amygdala

CNS:

Central nervous system

CSPP:

Corticostriatopallidopontine

DA:

Dopamine

dB:

Decibels

DP:

Dual pathology

ISI:

Interstimuli interval

mPFC:

Medial prefrontal cortex

NAcc:

Nucleus accumbens

OFC:

Orbitofrontal cortex

PPI:

Prepulse inhibition

SR :

Startle reflex

SUD :

Substance use disorder

VTA:

Ventral tegmental area

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Acknowledgments

We wish to thank to Guillermo Chuliá for his editing of the manuscript and Dr Terry D. Blumenthal for sharing his technical experience in electromyography with us. This work was supported by the following research grants: Ministerio de Economía y Competitividad. Proyecto I+D+i PSI2015-69649-R; and UV-INV-AE19-1203315.

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Authors and Affiliations

  1. Department of Psychobiology, Faculty of Psychology, University of Valencia, Valencia, Spain

    M. Carmen Arenas, Sergio Pujante-Gil & Carmen Manzanedo

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  1. M. Carmen Arenas
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  2. Sergio Pujante-Gil
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  3. Carmen Manzanedo
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Correspondence to M. Carmen Arenas .

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  1. Unit of Research “Neurobehavioral Mechanisms and Endophenotypes of Addictive Behavior” Department of Psychobiology, Faculty of Psychology, University of Valencia, Valencia, Spain

    MarĂ­a A. Aguilar

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Arenas, M.C., Pujante-Gil, S., Manzanedo, C. (2022). Prepulse Inhibition and Vulnerability to Cocaine Addiction. In: Aguilar, M.A. (eds) Methods for Preclinical Research in Addiction. Neuromethods, vol 174. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1748-9_3

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  • DOI: https://doi.org/10.1007/978-1-0716-1748-9_3

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