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Measuring the Effects of Circadian Rhythm-Related Manipulations on Depression-Like Behavior in Rodents: Forced Swim and Tail Suspension Tests

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Circadian Clocks

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2130))

Abstract

The forced swim and tail suspension tests are commonly used to determine the effects of circadian-related pharmacological, genetic, and environmental manipulations on depression-like behavior in rodents. Both tests involve scoring immobility of rodents in an inescapable condition. Here we describe how to set up and carry out these tests.

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Acknowledgments

Studies from our group were supported by grants from NIMH (MH082876, MH106460) and NIDA (DA037636, DA023988, DA039865), as well as The Brain and Behavior Foundation (NARSAD), International Mental Health Research Organization (IMHRO), and the McKnight Foundation for Neuroscience.

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Authors and Affiliations

  1. Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Chelsea A. Vadnie & Lauren M. DePoy

  2. Psychiatry and Clinical and Translational Science, Translational Neuroscience Program, Center for Neuroscience University of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Colleen A. McClung

Authors
  1. Chelsea A. Vadnie
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  2. Lauren M. DePoy
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  3. Colleen A. McClung
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Corresponding author

Correspondence to Colleen A. McClung .

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Editors and Affiliations

  1. Chronobiology and Sleep Research Group, Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland

    Steven A. Brown

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Vadnie, C.A., DePoy, L.M., McClung, C.A. (2021). Measuring the Effects of Circadian Rhythm-Related Manipulations on Depression-Like Behavior in Rodents: Forced Swim and Tail Suspension Tests. In: Brown, S.A. (eds) Circadian Clocks. Methods in Molecular Biology, vol 2130. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0381-9_5

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  • DOI: https://doi.org/10.1007/978-1-0716-0381-9_5

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0380-2

  • Online ISBN: 978-1-0716-0381-9

  • eBook Packages: Springer Protocols

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