Skip to main content
SpringerLink
Log in

Microenvironmental Regulation of Ovarian Cancer Metastasis

  • Chapter
  • First Online:
Book cover Ovarian Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 149))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

EGF:

- epidermal growth factor;

HB-EGF:

- heparin binding EGF;

CSF-1:

- colony stimulating factor-1;

DAPI:

- 4′ 6-diamidino-2-phenylindole;

Akt:

- protein kinase B;

PI3-kinase:

- phosphoinositide-3-kinase;

VEGF:

–vascular endothelial growth factor;

MCA-:

multi-cellular aggregate;

EOC-:

epithelial ovarian cancer;

OSE-:

ovarian surface epithelium;

LPA-:

lysophosphatidic acid;

TNF-:

tumor necrosis factor;

MMP-:

matrix metalloproteinase

References

  1. Landen CN, Birrer MJ, Sood AK. Early events in the pathogenesis of epithelial ovarian cancer. J Clin Oncol. 2008;26:995–1005.

    Article  PubMed  Google Scholar 

  2. Wong AST, Auersperg N. Normal ovarian surface epithelium. Cancer Treat Res. 2002;107:161–183.

    CAS  PubMed  Google Scholar 

  3. Darai E, Scoazec JY, Walker-Combrouze F, et al. Expression of cadherins in benign, borderline and malignant ovarian epithelial tumors: a clinicopathologic study of 60 cases. Hum Pathol. 1997;28:922–928.

    Article  CAS  PubMed  Google Scholar 

  4. Alper O, DeSantis ML, Stromberg K, et al. Anti-sense suppression of epidermal growth factor receptor expression alters cellular proliferation, cell adhesion and tumorigenicity in ovarian cancer cells. Int J Cancer. 2000;88:566–574.

    Article  CAS  PubMed  Google Scholar 

  5. Auersperg N, Maines-Bandiera S, Dyck HG, et al. Characterization of cultured human ovarian surface epithelial cells: phenotypic plasticity and premalignant changes. Lab Invest. 1994;71:510–518.

    CAS  PubMed  Google Scholar 

  6. Naora H. The heterogeneity of epithelial ovarian cancers: reconciling old and new paradigms. Expert Rev Mol Med. 2007;9:1–12.

    Article  PubMed  Google Scholar 

  7. Shih EM, Kurman RJ. Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am J Pathol. 2004;164:1511–1518.

    CAS  PubMed  Google Scholar 

  8. ACS Cancer Facts & Figures. Available at: www.cancer.org.

  9. Hoskins WJ. Prospective on ovarian cancer; why prevent? J Cell Biochem Suppl. 1995;23:189–199.

    Article  CAS  PubMed  Google Scholar 

  10. Ghosh S, Wu Y, Stack MS. Ovarian cancer-associated proteinases. Cancer Treat Res. 2002;107:331–354.

    CAS  PubMed  Google Scholar 

  11. Burleson KM, Hansen LK, Skubitz APN. Ovarian carcinoma spheroids disaggregate on type I collagen and invade live human mesothelial cell monolayers. Clin Exp Metastasis. 2004;21:685–697.

    Article  CAS  PubMed  Google Scholar 

  12. Burleson KM, Casey RC, Skubitz KM, et al. Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayers. Gynecol Oncol. 2004;93:170–181.

    Article  CAS  PubMed  Google Scholar 

  13. Burleson KM, Boente MP, Pambuccian SE, et al. Disaggregation and invasion of ovarian carcinoma ascites spheroids. J Transl Med. 2006;4:1–16.

    Article  Google Scholar 

  14. Hudson LG, Zeineldin R, Stack MS. Phenotypic plasticity of neoplastic ovarian epithelium: unique cadherin profiles in tumor progression. Clin Exp Metastasis. 2008;25:L643–L655.

    Article  Google Scholar 

  15. Kenny HA, Krausz T, Yamada SD, et al. Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extracellular matrices on adhesion and invasion of ovarian cancer cells to the omentum. Int J Cancer. 2007;121:1463–1472.

    Article  CAS  PubMed  Google Scholar 

  16. Offner FA, Obrist P, Stadlmann S, et al. IL6 secretion by human peritoneal mesothelial and ovarian cancer cells. Cytokine. 1995;7:542–547.

    Article  CAS  PubMed  Google Scholar 

  17. Mustea A, Pirvulescu C, Konsgen D, et al. Decreased IL1 RA concentration in ascites is associated with a significant improvement in overall survival in ovarian cancer. Cytokine. 2008;42:77–84.

    Article  CAS  PubMed  Google Scholar 

  18. Freedman RS, Deavers M, Liu J, et al. Peritoneal inflammation – a microenvironment for epithelial ovarian cancer. J Transl Med. 2004;2:23–33.

    Article  PubMed  Google Scholar 

  19. Papadaki L, Beilby JOW. The fine structure of the surface epithelium of the human ovary. J Cell Sci. 1971;8:445–465.

    CAS  PubMed  Google Scholar 

  20. Czernobilsky B, Moll R, Levy M, et al. Co-expression of cytokeratin and vimentin filaments in mesothelial, granulosa and rete ovarii cells of the human ovary. Eur J Cell Biol. 1985;37:175–190.

    CAS  PubMed  Google Scholar 

  21. Kruk PA, Uitto VJ, Firth JD, et al. Reciprocal interactions between human ovarian surface epithelial cells and adjacent extracellular matrix. Exp Cell Res. 1994;215:97–108.

    Article  CAS  PubMed  Google Scholar 

  22. Carreiras F, Denoux Y, Staedel C, et al. Expression and localization of alphav integrins and their ligand vitronectin in normal ovarian epithelium and in ovarian carcinoma. Gynecol Oncol. 1996;62:260–267.

    Article  CAS  PubMed  Google Scholar 

  23. Skubitz AP, Bast RC, Wayner EA, et al. Expression of alpha 6 and beta 4 integrins in serous ovarian carcinoma correlates with expression of the basement membrane protein laminin. Am J Pathol. 1996;148:1445–1461.

    CAS  PubMed  Google Scholar 

  24. Bridges JE, Englefield P, Boyd IE, et al. Expression of integrin adhesion molecules in normal ovary and epithelial ovarian tumors. Int J Gynecol Cancer. 1995;5:187–192.

    Article  PubMed  Google Scholar 

  25. Shield K, Riley C, Quinn MA, et al. Alpha2beta1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis. J Carcinog. 2007;14:6–11.

    Google Scholar 

  26. Sawada K, Mitra AK, Radjabi AR, et al. Loss of E-cadherin promotes ovarian cancer metastasis via alpha5 integrin, which is a therapeutic target. Cancer Res. 2008;68:2329–2339.

    Article  CAS  PubMed  Google Scholar 

  27. Moser TL, Pizzo SV, Bafetti LM, et al. Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type I collagen mediated by the alpha2beta1 integrin. Int J Cancer. 1996;67:695–701.

    Article  CAS  PubMed  Google Scholar 

  28. Fishman DA, Kearns AM, Chilikuri K, et al. Metastatic dissemination of human ovarian epithelial carcinoma is promoted by α2β1 integrin–mediated interaction with type I collagen. Invasion Metastasis. 1998;18:15–26.

    Article  CAS  PubMed  Google Scholar 

  29. Ellerbroek SM, Fishman DA, Kearns AS, et al. Ovarian carcinoma regulation of matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase through beta1 integrin. Cancer Res. 1999;59:1635–1641.

    CAS  PubMed  Google Scholar 

  30. Barbolina MV, Adley BP, Ariztia EV, et al. Microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced EGR1 expression. J Biol Chem. 2007;282:4924–4931.

    Article  CAS  PubMed  Google Scholar 

  31. Davidson B, Goldberg I, Reich R, et al. AlphaV and beta1-integrin subunits are commonly expressed in malignant effusions from ovarian carcinoma patients. Gynecol Oncol. 2003;90:248–257.

    Article  CAS  PubMed  Google Scholar 

  32. Davies BR, Worsley SD, Ponder BA. Expression of E-cadherin, alpha-catenin and beta-catenin in normal ovarian surface epithelium and ovarian cancers. Histopathology. 1998;32:69–80.

    Article  CAS  PubMed  Google Scholar 

  33. Ho EY, Choi Y, Chae SW, et al. Immunohistochemical study of the expression of adhesion molecules in ovarian serous neoplasms. Pathol Int. 2006;56:62–70.

    Article  Google Scholar 

  34. Voutilainen KA, Anttila MA, Sillanpaa SM, et al. Prognostic significance of E-cadherin–catenin complex in epithelial ovarian cancer. J Clin Pathol. 2006;59:460–467.

    Article  CAS  PubMed  Google Scholar 

  35. Forgacs G, Foty RA, Shafrir Y, et al. Viscoelastic properties of living embryonic tissues: a quantitative study. Biophys J. 1998;74:2227–2234.

    Article  CAS  PubMed  Google Scholar 

  36. Foty RA, Pfleger CM, Forgacs G, et al. Surface tensions of embryonic tissues predict their mutual envelopment behavior. Development. 1996;122:1611–1620.

    CAS  PubMed  Google Scholar 

  37. Duguay D, Foty RA, Steinberg MS. Cadherin-mediated cell adhesion and tissue segregation: qualitative and quantitative determinants. Dev Biol. 2003;253:309–323.

    Article  CAS  PubMed  Google Scholar 

  38. diZerega GS, Rodgers KE. The Peritoneum. New York: Springer-Verlag; 1992.

    Google Scholar 

  39. Shen-Gunther J, Mannel RS. Ascites as a predictor of ovarian malignancy. Gynecol Oncol. 2002;87:77–83.

    Article  PubMed  Google Scholar 

  40. Rahaman J, Cohen CJ. Impact of ascites on survival in advanced ovarian cancer. Proc Am Soc Clin Oncol. 2002;21:837.

    Google Scholar 

  41. Ayhan A, Gultekin M, Taskiran C, et al. Ascites and epithelial ovarian cancers: a reappraisal with respect to different aspects. Int J Gynecol Cancer. 2006;17:68–75.

    Article  Google Scholar 

  42. Gortzak-Uzan L, Ignatchenko A, Evangelou AI, et al. A proteome resource of ovarian cancer ascites: integrated proteomic and bioinformatics analyses to identify putative biomarkers. J Proteome Res. 2008;7:339–351.

    Article  CAS  PubMed  Google Scholar 

  43. Xu Y, Gaudette DC, Boynton JD, et al. Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients. Clin Cancer Res. 1995;1:1223–1232.

    CAS  PubMed  Google Scholar 

  44. Xu Y, Shen Z, Wiper DW, et al. Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers. JAMA. 1998;280:719–723.

    Article  CAS  PubMed  Google Scholar 

  45. Fang X, Yu S, Bast RC, et al. Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells. J Biol Chem. 2004;279:9653–9661.

    Article  CAS  PubMed  Google Scholar 

  46. Hagemann T, Wilson J, Burke F, et al. Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype. J Immunol. 2006;176:5023–5032.

    CAS  PubMed  Google Scholar 

  47. Reddy P, Liu L, Ren C, et al. Formation of E-cadherin mediated cell–cell adhesion activates AKT and MAPK via PI3 kinase and ligand-independent activation of epidermal growth factor receptor in ovarian cancer cells. Mol Endocrinol. 2005;19:2564–2578.

    Article  CAS  PubMed  Google Scholar 

  48. Hudson LG, Zeineldin R, Silberberg M, et al. Activated epidermal growth factor receptor in ovarian cancer. Cancer Treat Res. 2009;149.

    Google Scholar 

  49. Lafky JM, Wilken JA, Baron AT, et al. Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer. Biochim Biophys Acta. 2008;1785:232–265.

    CAS  PubMed  Google Scholar 

  50. Said N, Socha MJ, Olearczyk JJ, et al. Normalization of the ovarian cancer microenvironment by SPARC. Mol Cancer Res. 2007;5:1015–1030.

    Article  CAS  PubMed  Google Scholar 

  51. Santala M, Risteli J, Risteli L, et al. Synthesis and breakdown of fibrillar collagens: concomitant phenomena in ovarian cancer. Br J Cancer. 1998;77:1825–1831.

    CAS  PubMed  Google Scholar 

  52. Abdel Axia MT, Abdel Aziz Wassef M, Kamel M, et al. Clinical evaluation of serum aminoterminal propeptide of type III procollagen as tumor marker in gynecologic malignancies. Tumori. 1993;79:219–223.

    Google Scholar 

  53. Zhu GG, Risteli J, Puistola U, et al. Progressive ovarian carcinoma induces synthesis of type I and type III procollagens in the tumor tissue and peritoneal cavity. Cancer Res. 1993;53:5028–5032.

    CAS  PubMed  Google Scholar 

  54. Mills GB, Eder A, Fang X, et al. Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer. Cancer Res Treat. 2002;107:259–284.

    CAS  Google Scholar 

  55. Do TV, Symowicz JC, Berman DM, et al. Lysophosphatidic acid down-regulates stress fibers and up-regulates pro-matrix metalloproteinase-2 activation in ovarian cancer cells. Mol Cancer Res. 2007;5:121–131.

    Article  CAS  PubMed  Google Scholar 

  56. Symowicz J, Adley BP, Woo MM, et al. Cyclooxygenase-2 functions as a downstream mediator of lysophosphatidic acid to promote aggressive behavior in ovarian carcinoma cells. Cancer Res. 2005;65:2234–2242.

    Article  CAS  PubMed  Google Scholar 

  57. Fishman DA, Liu, Y, Ellerbroek SM, et al. Lysophosphatidic acid promotes matrix metalloproteinase (MMP) activation and MMP-dependent invasion in ovarian cancer cells. Cancer Res. 2001;61:3194–3199.

    CAS  PubMed  Google Scholar 

  58. Graves LE, Ariztia EV, Navari JR, et al. Proinvasive properties of ovarian cancer ascites-derived membrane vesicles. Cancer Res. 2004;64:7045–7049.

    Article  CAS  PubMed  Google Scholar 

  59. Lee Z, Swaby RF, Liang Y, et al. Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer. Cancer Res. 2006;66:2740–2748.

    Article  CAS  PubMed  Google Scholar 

  60. Said NA, Najwer I, Socha MJ, et al. SPARC inhibits LPA-mediated mesothelial-ovarian cancer cell crosstalk. Neoplasia. 2007;9:23–35.

    Article  CAS  PubMed  Google Scholar 

  61. Robinson-Smith TM, Isaacsohn I, Mercer CA, et al. Macrophages mediate inflammation-enhanced metastasis of ovarian tumors in mice. Cancer Res. 2007;67:5708–5716.

    Article  CAS  PubMed  Google Scholar 

  62. Hageman T, Robinson SC, Thompson RG, et al. Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis. Mol Cancer Ther. 2007;6:1993–2002.

    Article  Google Scholar 

  63. Kassis J, Lkominek J, Kohn EC. Tumor microenvironment: what can effusions teach us? Diagn Cytopathol. 2004;33:316–319.

    Article  Google Scholar 

  64. Greenaway J, Moorehead R, Shaw P, et al. Epithelial–stromal interaction increases cell proliferation, survival and tumorigenicity in a mouse model of human epithelial ovarian cancer. Gynecol Oncol. 2008;108:385–394.

    Article  CAS  PubMed  Google Scholar 

  65. Zietarska M, Maugard CM, Filali-Mouhim A, et al. Molecular description of a 3D in vitro model for the study of epithelial ovarian cancer (EOC). Mol Carcinog. 2007;46:872–885.

    Article  CAS  PubMed  Google Scholar 

  66. Zhang S, Balch C, Chan MW, et al. Identification and characterization of ovarian cancer initiating cells from primary human tumors. Cancer Res. 2008;68:4311–4320.

    Article  CAS  PubMed  Google Scholar 

  67. Hegedus B, Marga F, Jakab K, et al. The interplay of cell–cell and cell–matrix interactions in the invasive properties of brain tumors. Biophys J. 2006;91:2708–2720.

    Article  CAS  PubMed  Google Scholar 

  68. Battifora H, McCaughey WTE. Tumors of the serosal membranes. In: Atlas of Tumor Pathology, Third Series, Fascicle 15. Washington, DC: Armed Forces Institute of Pathology; 1994:1–117.

    Google Scholar 

  69. Zhang XY, Pettengell R, Nasiri N, et al. Characteristics and growth patterns of human peritoneal mesothelial cells: comparison between advanced epithelial ovarian cancer and non-ovarian cancer sources. J Soc Gynecol Investig. 1999;6:333–340.

    Article  CAS  PubMed  Google Scholar 

  70. Wang E, Ngalame Y, Panelli MC, et al. Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer. Clin Cancer Res. 11:113–122.

    Google Scholar 

  71. Cannistra SA, Kansas GS, Niloff J. et al. Binding of ovarian cancer cells to peritoneal mesothelium in vitro is partly mediated by CD44H. Cancer Res. 1993;53:3830–3838.

    CAS  PubMed  Google Scholar 

  72. Ahmed N, Riley C, Rice G, et al. Role of integrin receptors for fibronectin, collagen and laminin in the regulation of ovarian carcinoma functions in response to a matrix microenvironment. Clin Exp Metastasis. 2005;22:391–402.

    Article  CAS  PubMed  Google Scholar 

  73. Niedbala MJ, Crickard K, Bernacki RJ. In vitro degradation of extracellular matrix by human ovarian carcinoma cells. Clin Exp Metastasis. 1987;5:181–197.

    Article  CAS  PubMed  Google Scholar 

  74. Sawada M, Shii J, Akedo H, et al. An experimental model for ovarian tumor invasion of cultured mesothelial cell monolayer. Lab Invest. 1994;70:333–338.

    CAS  PubMed  Google Scholar 

  75. Harvey W, Amlot, P. Colalgen production by human mesothelial cells in vitro. J Pathol. 1983;139:337–347.

    Article  CAS  PubMed  Google Scholar 

  76. Stylianou E, Jenner LA, Davies M, et al. Isolation, culture and characterization of human peritoneal mesothelial cells. Kidney Int. 1990;37:1563–1570.

    Article  CAS  PubMed  Google Scholar 

  77. Ellerbroek SM, Wu YI, Overall CM, et al. Functional interplay between type I collagen and cell surface matrix metalloproteinase activity. J Biol Chem. 2001;276:24833–24842.

    Article  CAS  PubMed  Google Scholar 

  78. Hotary KB, Allen ED, Brooks PC, et al. Membrane type 1 matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix. Cell. 2003;114:33–45.

    Article  CAS  PubMed  Google Scholar 

  79. Symowicz J, Adley BP, Gleason KJ, et al. Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells. Cancer Res. 2007;67:2030–2039.

    Article  CAS  PubMed  Google Scholar 

  80. Barbolina M, Adley, BP, Kelly, et al. Motility-related actinin alpha-4 is associated with advanced and metastatic ovarian carcinoma. Lab Invest. 2008;88:602–614.

    Article  CAS  PubMed  Google Scholar 

  81. Barbolina MV, Adley BP, Shea LD, et al. Wilms tumor gene protein 1 is associated with ovarian cancer metastasis and modulates cell invasion. Cancer. 2008;112:1632–1641.

    Article  CAS  PubMed  Google Scholar 

  82. BarbolinaMV, Adley BP, Kelly DL, et al. Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion. Int J Cancer. 2009 (in press).

    Google Scholar 

  83. Langer S, Singer CF, Hudelist G, et al. Jun and Fos family protein expression in human breast cancer: correlation of protein expression and clinicopathological parameters. Eur J Gynaecol Oncol. 2006;27:345–352.

    CAS  PubMed  Google Scholar 

  84. Zhai Y, Hotary KB, Nan B, et al. Expression of membrane type 1 matrix metalloproteinase is associated with cervical carcinoma progression and invasion. Cancer Res. 2005;65:6543–6550.

    Article  CAS  PubMed  Google Scholar 

  85. Schaller G, Fuchs I, Ebert A, et al. The clinical importance of keratin 18 in breast cancer. Zentralbl Gynakol. 1999;121:126–130.

    CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by grants from the 2005–2006 and 2007–2008 Penny Severns Breast, Cervical and Ovarian Cancer Fund, Illinois Department of Public Health (M.V.B.), the Ovarian Cancer Research Foundation Program of Excellence (M.V.B.), National Science Foundation NSF-0526854 (G.F.), and National Institutes of Health/National Cancer Institute Research Grants RO1CA86984 (M.S.S.), RO1CA086984-S1 (N.M.), and RO1CA109545 (M.S.S. and L.G.H.).

Author information

Authors and Affiliations

  1. Department of Biopharmaceutical Sciences, University of Illinois, Chicago, IL, USA

    Maria V. Barbolina

  2. Department of Cell & Molecular Biology, Northwestern University, Chicago, IL, USA

    Natalie M. Moss

  3. Departments of Pathology & Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO, USA

    Suzanne D. Westfall, Yueying Liu & Rebecca J. Burkhalter

  4. Departments of Physics, University of Missouri School of Medicine, Columbia, MO, USA

    Francoise Marga

  5. Departments of Physics; Biological Sciences; Biomedical Engineering, University of Missouri School of Medicine, Columbia, MO, USA

    Gabor Forgacs

  6. Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, 87131-0001, Albuquerque, NM, USA

    Laurie G. Hudson

  7. Department of Pathology & Anatomical Sciences, 1 Hospital Drive, Room M214C Medical Sciences Bldg., 65212, Columbia, MO, USA

    M. Sharon Stack PhD

Authors
  1. Maria V. Barbolina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Natalie M. Moss
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Suzanne D. Westfall
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yueying Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rebecca J. Burkhalter
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Francoise Marga
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Gabor Forgacs
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Laurie G. Hudson
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. M. Sharon Stack PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. School of Medicine, University of Missouri, Hospital Dr. 1, Columbia, 65212, U.S.A.

    M. Sharon Stack

  2. School of Medicine, New York University, First Ave. 550, New York, 10016, U.S.A.

    David A. Fishman

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Barbolina, M.V. et al. (2009). Microenvironmental Regulation of Ovarian Cancer Metastasis. In: Stack, M., Fishman, D. (eds) Ovarian Cancer. Cancer Treatment and Research, vol 149. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-98094-2_15

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-98094-2_15

  • Published:

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-98093-5

  • Online ISBN: 978-0-387-98094-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation