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Intracellular Membrane Fusion

  • Chapter
Trafficking Inside Cells

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Fusion of biological membranes plays an important role in cell structure and function. It is essential for organelle biogenesis, vesicle targeting, constitutive and regulated exocytosis, endocytosis, pathogen invasion of host cells, sperm-egg fusion and skeletal muscle formation. This chapter summarizes our current knowledge of the mechanisms of intracellular membrane fusion with particular emphasis on the structure, function and regulation of the N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein family. The chapter provides details of current ideas on SNARE mechanisms of action in membrane fusion and the conserved features of SNARE complexes. Also covered in detail are SNARE regulation; by lipids, SNARE amino-terminal (NT) domains, posttranslational modifications, SM proteins, tethering proteins, calcium and other regulators. Fusion mechanisms employed by enveloped viruses are also summarized to provide a broader perspective.

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Authors and Affiliations

  1. Division of Biological Sciences and Center for Structural and Functional Neuroscience, The University of Montana, Missoula, Montana, 59812, USA

    Jesse C. Hay

  2. Institute of Biochemistry II Frankfurt Medical School, University Hospital, Frankfurt, Germany

    Dalu Xu

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  1. Dalu Xu
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  2. Jesse C. Hay
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Correspondence to Jesse C. Hay .

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© 2009 Landes Bioscience and Springer Science+Business Media

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Xu, D., Hay, J.C. (2009). Intracellular Membrane Fusion. In: Trafficking Inside Cells. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-93877-6_14

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