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Early Cooling in Cardiac Arrest: What is the Evidence?

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Intensive Care Medicine

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Abstract

Cardiac arrest is a major cause of unexpected death in developed countries, with survival rates ranging from less than 5% to 35% [1, 2]. In patients who are initially resuscitated, anoxic neurological injury is an important cause of morbidity and mortality [3]. For successful resuscitation, rapid return to spontaneous circulation is mandatory, but overcoming post-resuscitation tissue injury is necessary as well [4, 5]. Various treatment strategies have been used to attenuate ischemic-related pathophysiological damage and behavioral deficits. Prolonged therapeutic hypothermia is the only post-resuscitation therapy clinically demonstrated to improve the outcome of cardiac arrest survivors [6–9]. Therapeutic hypothermia is recommended by the International Liaison Committee on Resuscitation (ILCOR) [8].

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Author information

Authors and Affiliations

  1. Department of Intensive Care, Grenoble University Hospital, BP 21738043, Grenoble, France

    L. Hammer & J. -F. Timsit

  2. Department of Intensive Care, Delafontaine Hospital, Rue Dr P Delafontaine, 293205, Saint Denis, France

    C. Adrie

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  1. L. Hammer
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  2. C. Adrie
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  3. J. -F. Timsit
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Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Université libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium

    Jean-Louis Vincent MD, PhD, FCCM, FCCP (Head) (Head)

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Hammer, L., Adrie, C., Timsit, J.F. (2008). Early Cooling in Cardiac Arrest: What is the Evidence?. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77383-4_13

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  • DOI: https://doi.org/10.1007/978-0-387-77383-4_13

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-77382-7

  • Online ISBN: 978-0-387-77383-4

  • eBook Packages: MedicineMedicine (R0)

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