Retinoschisin (RS), the product of the RS1 gene on the X-chromosome (Xp22), is a 24 kDa secreted protein which is expressed exclusively in the retina (Reid et al., 1999; Sauer et al., 1997) and pineal gland (Takada et al., 2006). In the retina, photoreceptors, bipolar cells, and ganglion cells synthesize RS (Takada et al., 2004). The structural features and functional implications of the 224 amino acid RS sequence include a N-terminus signal peptide (amino acids 1–23) and a 157 amino acid (amino acids 68–217) discoidin domain (Reid et al., 1999; Sauer et al., 1997). The signal peptide guides the secretion of mature RS across the plasma membrane and is cleaved off during the translocation process (Molday, 2007).
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Vijayasarathy, C., Takada, Y., Zeng, Y., Bush, R.A., Sieving, P.A. (2008). Organization and Molecular Interactions of Retinoschisin in Photoreceptors. In: Anderson, R.E., LaVail, M.M., Hollyfield, J.G. (eds) Recent Advances in Retinal Degeneration. Advances in Experimental Medicine and Biology, vol 613. Springer, New York, NY. https://doi.org/10.1007/978-0-387-74904-4_34
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