We developed a single compartment model of a mammalian CO2 sensitive neuron and tested the hypothesis that pH-dependent inhibition of multiple potassium channels contributes to CO2 sensitivity. pH-dependent inhibition of potassium channels by either intracellular or extracellular pH was sufficient to alter neuronal activity, but changes in neither intracellular nor extracellular pH are required to elicit a neuronal response to hypercapnic stimulation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Boron, W.F. and De Weer, P. (1976) Intracellular pH transients in squid giant axons caused by CO2, NH3, and metabolic inhibitors. J. Gen. Physiol. 67, 91–112.
Chernov, M.M., Daubenspeck, J.A., Denton, J.S., Pfeiffer, J.R., Putnam, R.W. and Leiter, J.C. (2007) A computational analysis of central CO2 chemosensitivity in Helix aspersa. Am. J. Physiol., 292, C278–291.
Denton, J.S., McCann, F.V. and Leiter, J.C. (2007) CO2 chemosensitivity in Helix aspersa: Three K+ currents mediate pH-sensitive neuronal activity. Am. J. Physiol., 292, C292–304.
Leem, C.H., Lagadic-Gossman, D. and Vaughan-Jones, R.D. (1999) Characterization of intracellular pH regulation in guinea-pig ventricular myocyte. J. Physiol. (Lond.) 517.1, 159–180.
Nottingham, S., Leiter, J.C., Wages, P., Buhay, S. and Erlichman, J.S. (2001) Developmental changes in intracellular pH regulation in medullary neurons of the rat. Am. J. Physiol. 281, R1940–R1951.
Padanilam, B.J., Lu, T., Hoshi, T., Padanilam, B.A., Shibata, E.F. and Lee, H.-C. (2002) Molecular determinants of intracellular pH modulation of human Kv1.4 N-type inactivation. Molec. Pharmacol. 62, 127–134.
Putnam, R.W., Filosa, J.A. and Ritucci, N.A. (2004) Cellular mechanisms involved in CO2 and acid sensing in chemosensitive neurons. Am. J. Physiol. 287, C1493–C1526.
Ritucci, N.A., Dean, J.B. and Putnam, R.W. (1997) Intracellular pH response to hypercapnia in neurons from chemosensitive areas of the medulla. Am. J. Physiol. 273, R433–R441.
Rybak, I., Paton, J.F.R. and Schwaber, J.S. (1997) Modeling neural mechanisms for genesis of respiratory rhythm and pattern. I. Models of respiratory neurons. J. Neurophysiol. 77, 1994–2006.
Washburn, C.P., Sirois, J.E., Talley, E.M., Guyenet, P. and Bayliss, D.A. (2002) Serotonergic raphe neurons express TASK channel transcripts and a TASK-like pH- and halothane-sensitive K+ conductance. J. Neurosci. 22, 1256–1265.
Williams, J.T., North, R.A. and Tokimasa, T. (1988) Inward rectification of resting and opitate-activated potassium currents in rat locus coeruleus neurons. J. Neurosci. 8, 4299–4306.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer
About this chapter
Cite this chapter
Chernov, M., Putnam, R.W., Leiter, J.C. (2008). A Computer Model of Mammalian Central CO2 Chemoreception. In: Poulin, M.J., Wilson, R.J.A. (eds) Integration in Respiratory Control. Advances in Experimental Medicine and Biology, vol 605. Springer, New York, NY. https://doi.org/10.1007/978-0-387-73693-8_52
Download citation
DOI: https://doi.org/10.1007/978-0-387-73693-8_52
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-73692-1
Online ISBN: 978-0-387-73693-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)