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Actin-Binding Proteins and Disease

  • Book
  • © 2008

Overview

Editors:
  1. Cristobal G. Remedios

    1. Muscle Research Unit Bosch Institute, School of Medical Sciences, The University of Sydney, Sydney, Australia

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  2. Deepak Chhabra

    1. Discipline of Anatomy and Histology Bosch Institute, School of Medical Sciences, The University of Sydney, Sydney, Australia

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    You can also search for this editor in PubMed   Google Scholar

  • Will appeal to research scientists seeking contemporary overviews of actin-myosin interaction and actin-based regulation

Part of the book series: Protein Reviews (PRON, volume 8)

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About this book

Actin is a ubiquitous protein present in high concentrations in virtually all cells. It's assembly and disassembly is modulated by more than 100 actin-binding proteins. These interactions are essential for a variety of important cellular processes including cell division, gene expression and motility.

There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders.

This volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole. Additionally, clinicians will be interested because the book explains the role of cytoskeletal proteins in various diseases, including cancer and immune system disorders.

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Actin

    1. Actin: An Overview of Its Structure and Function

      • Deepak Chhabra, Cristobal G. dos Remedios
      Pages 1-15

    2. Actin Genetic Diseases

      • John C. Sparrow, Nigel G. Laing
      Pages 16-36

    3. Actin-Binding Drugs: An Elegant Tool to Dissect Subcellular Processes in Endothelial and Cancer Cells

      • Filip Braet, Lilian Soon, Katrien Vekemans, Pall Thordarson, Ilan Spector
      Pages 37-49

    4. Autoantigenicity of Actin

      • Ian R. Mackay, Roberto Martinez-Neira, Senga Whittingham, Dan Nicolau, Ban-Hock Toh
      Pages 50-64

  3. Actin-Binding Proteins

    1. Overview: Actin-Binding Protein Function and Its Relation to Disease Pathology

      • Mira Krendel, Enrique M. De La Cruz
      Pages 65-82

    2. ADF/Cofilin, Actin Dynamics, and Disease

      • Michael T. Maloney, Andrew W. Kinley, Chi W. Pak, James R. Bamburg
      Pages 83-187

    3. Gelsolin and Disease

      • Leslie D. Burtnick, Robert C. Robinson
      Pages 188-199

    4. Profilin

      • Pierre D. J. Moens
      Pages 200-217

    5. The Roles of Thymosin β4 in Cell Migration and Cell-to-Cell Signaling in Disease

      • Joshua K. Au, Mira Krendel, Daniel Safer, Enrique M. De La Cruz
      Pages 218-228

  4. Actin-Binding Proteins

    1. Actin and Actin-Binding Proteins in Cancer Progression and Metastasis

      • Marleen Van Troys, Joël Vandekerckhove, Christophe Ampe
      Pages 229-277

    2. Diseases with Abnormal Actin and Actin-Binding Proteins in Leukocyte and Nonmuscle Cells

      • Hiroyuki Nunoi
      Pages 278-289

    3. The Role of PIP2 in Actin, Actin-Binding Proteins and Disease

      • C. G. dos Remedios, Neil J. Nosworthy
      Pages 290-297

    4. Intracellular Pathogens and the Actin Cytoskeleton

      • E. L. Bearer
      Pages 298-317

    5. Actin and Its Binding Proteins in Heart Failure

      • Maurizio Stefani, Masako Tsubakihara, Brett D. Hambly, Choon C. Liew, Paul D. Allen, Peter S. Macdonald et al.
      Pages 318-334

  5. Back Matter

    Pages 335-348
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Editors and Affiliations

  • Muscle Research Unit Bosch Institute, School of Medical Sciences, The University of Sydney, Sydney, Australia

    Cristobal G. Remedios

  • Discipline of Anatomy and Histology Bosch Institute, School of Medical Sciences, The University of Sydney, Sydney, Australia

    Deepak Chhabra

Bibliographic Information

  • Book Title: Actin-Binding Proteins and Disease

  • Editors: Cristobal G. Remedios, Deepak Chhabra

  • Series Title: Protein Reviews

  • DOI: https://doi.org/10.1007/978-0-387-71749-4

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag New York 2008

  • Hardcover ISBN: 978-0-387-71747-0Published: 26 November 2007

  • Softcover ISBN: 978-1-4419-2453-7Published: 19 November 2010

  • eBook ISBN: 978-0-387-71749-4Published: 08 January 2008

  • Edition Number: 1

  • Number of Pages: XIV, 348

  • Number of Illustrations: 30 b/w illustrations, 22 illustrations in colour

  • Topics: Cell Biology, Proteomics, Protein Science, Biochemistry, general

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