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Microarray Technology and Cancer Gene Profiling

  • Book
  • © 2007

Overview

Editors:
  1. Simone Mocellin

    1. Clinica Chirurgica II, Dipartimento di Scienze Oncologiche e Chirurgiche, University of Padova, Padova, Italy

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  • Each chapter is written by a leader in the field
  • Contains detailed illustrations

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 593)

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About this book

Cancer is a heterogeneous disease in most respects, including its cellularity, different genetic alterations and diverse clinical behaviors. Traditional molecular analyses are reductionist, assessing only one or a few genes at a time, thus working with a biologic model too specific and limited to confront a process whose clinical outcome is likely to be governed by the combined influence of many genes. The potential of functional genomics is enormous, because for each experiment, thousands of relevant observations can be made simultaneously. Accordingly, DNA array, as other high throughput technologies, might catalyze and ultimately accelerate the development of knowledge in tumor cell biology. Although in its infancy, the implementation of DNA array technology in cancer research has already provided investigators with novel data and intriguing new hypotheses on the molecular cascade leading to cancerogenesis, tumor aggressiveness and sensitivity to antineoplastic agents. Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, principles of DNA array-based tumor gene profiling need to be clearly understood for the data to be correctly interpreted and appreciated. In the present book, written by leading experts in each field, the technical features characterizing this powerful laboratory tool are discussed, and the applications so far described in the field of oncology are reviewed.

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Keywords

Table of contents (14 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Microarray Technology

    1. Manufacturing of Microarrays

      • David W. Petersen, Ernest S. Kawasaki
      Pages 1-11

    2. Technological Platforms for Microarray Gene Expression Profiling

      • Susanna Mandruzzato
      Pages 12-18

    3. Principles of Gene Microarray Data Analysis

      • Simone Mocellin, Carlo Riccardo Rossi
      Pages 19-30

    4. Gaining Weights ... and Feeling Good about It!

      • Ernst Wit, Vilda Purutcuoglu, Lucy O’Donovan, Ximin Zhu
      Pages 31-38

    5. Complementary Techniques

      • Ena Wang, Monica Panelli, Francesco M. Marincola
      Pages 39-53

    6. Complementary Techniques

      • Giovanni Esposito
      Pages 54-65

    7. Complementary Techniques

      • Maurizio Provenzano, Simone Mocellin
      Pages 66-73

  3. Applications in the Oncology Field

    1. Microarrays for Cancer Diagnosis and Classification

      • Ainhoa Perez-Diez, Andrey Morgun, Natalia Shulzhenko
      Pages 74-85

    2. Gene Profiling for the Prediction of Tumor Response to Treatment

      • Vladia Monsurrò, Francesco M. Marincola
      Pages 86-94

    3. Identification of Molecular Determinants of Tumor Sensitivity and Resistance to Anticancer Drugs

      • Luigi Quintieri, Marianna Fantin, Csaba Vizier
      Pages 95-104

    4. SNP and Mutation Analysis

      • Lu Wang, Robert Luhm, Ming Lei
      Pages 105-116

    5. Cancer Development and Progression

      • Mei He, Jennifer Rosen, David Mangiameli, Steven K. Libutti
      Pages 117-133

    6. Gene Expression Profiling in Malignant Lymphomas

      • Sarah E. Henrickson, Elena M. Hartmann, German Ott, Andreas Rosenwald
      Pages 134-146

    7. Tumor Immunology

      • Simone Mocellin, Mario Lise, Donato Nitti
      Pages 147-156

  4. Back Matter

    Pages 157-159
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Editors and Affiliations

  • Clinica Chirurgica II, Dipartimento di Scienze Oncologiche e Chirurgiche, University of Padova, Padova, Italy

    Simone Mocellin

Bibliographic Information

  • Book Title: Microarray Technology and Cancer Gene Profiling

  • Editors: Simone Mocellin

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-0-387-39978-2

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2007

  • Hardcover ISBN: 978-0-387-39977-5Published: 04 December 2006

  • Softcover ISBN: 978-1-4419-2298-4Published: 19 November 2010

  • eBook ISBN: 978-0-387-39978-2Published: 28 August 2007

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVIII, 159

  • Topics: Oncology, Cancer Research

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