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Molecular Pathology in Clinical Practice pp 15–40Cite as

Molecular Pathology Methods

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Abstract

Molecular pathology is based on the principles, techniques, and tools of molecular biology as they are applied to diagnostic medicine in the clinical laboratory. These tools were developed in the research setting and perfected throughout the second half of the 20th century, long before the Human Genome Project was conceived. Molecular biology methods were used to elucidate the genetic and molecular basis of many diseases, and these discoveries ultimately led to the field of molecular diagnostics. Eventually the insights these tools provided for laboratory medicine were so valuable to the armamentarium of the pathologist that they were incorporated into pathology practice. Today, molecular diagnostics continues to grow rapidly as in vitro diagnostic companies develop new kits for the marketplace and as the insights into disease gained by the progress of the Human Genome Project develop into laboratory tests.

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Author information

Authors and Affiliations

  1. St Joseph Hospital, Eureka, CA, 95501, USA

    Megan J. Smith-Zagone MD (Pathologist)

  2. Department of Pathology, Baylor College of Medicine, Methodist Hospital, Houston, TX, 77030, USA

    Joseph F. Pulliam MD

  3. Molecular Diagnostics, Department of Pathology, The Methodist Hospital, Houston, TX, 77030

    Daniel H. Farkas PhD, HCLD (Director and Associate Professor)

  4. Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, 10021, USA

    Daniel H. Farkas PhD, HCLD (Director and Associate Professor)

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  1. Megan J. Smith-Zagone MD
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  2. Joseph F. Pulliam MD
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  3. Daniel H. Farkas PhD, HCLD
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Editor information

Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY, 10021, USA

    Debra G. B. Leonard MD, PhD (Professor and Vice Chair for Laboratory Medicine) (Professor and Vice Chair for Laboratory Medicine)

  2. Hematology, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Adam Bagg MD (Director) (Director)

  3. Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA, 30322, USA

    Angela M. Caliendo MD, PhD (Vice Chair and Associate Professor) (Vice Chair and Associate Professor)

  4. Northwestern University Feinberg School of Medicine, Evanston, IL, 60201

    Karen L. Kaul MD, PhD (Professor) (Professor)

  5. Department of Pathology and Laboratory Medicine, Evanston Northwestern Healthcare, Evanston, IL, 60201, USA

    Karen L. Kaul MD, PhD (Professor) (Professor)

  6. Molecular Pathology Laboratory, Department of Pathology and Laboratory Medicine, University of Pennsylvania Health System, Philadelphia, PA, 19104, USA

    Vivianna M. Van Deerlin MD, PhD (Director) (Director)

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Smith-Zagone, M.J., Pulliam, J.F., Farkas, D.H. (2007). Molecular Pathology Methods. In: Leonard, D.G.B., Bagg, A., Caliendo, A.M., Kaul, K.L., Van Deerlin, V.M. (eds) Molecular Pathology in Clinical Practice. Springer, New York, NY. https://doi.org/10.1007/978-0-387-33227-7_2

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  • DOI: https://doi.org/10.1007/978-0-387-33227-7_2

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