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Nanoporous Microsystems for Islet Cell Replacement

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BioMEMS and Biomedical Nanotechnology

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Abstract

Micro-Electro-Mechanical Systems technology, commonly known with the acronym MEMS, refers to the fabrication of devices with dimensions on the micrometer scale. For comparison, a human hair is about 80 min diameter. The most essential elements of MEMS consist of miniaturized, highly precise, and repeatable structures that can be stationary or moving. These structures are created via fabrication processes and equipment developed for the integrated circuit (IC) industry. The fabrication of MEMS commonly involves bulk or surface machining. Bulk machining defines microstructures by etching directly into the bulk material such as single crystal silicon. The advantage of bulk machining is that it allows the integration of active devices and the use of integrated circuit technology. Surface machining defines the release and movable structure in a polysilicon film or sacrificial layer of silicon dioxide, both deposited on bulk silicon. More complex microchips including multilayer interconnections can be obtained by bonding together and laser drilling of several layers of the components. Typically, microfabrication has a limit of resolution on the order of microns. However, specialized techniques can be used to create features in the nanoscale, as it will be shown later in the fabrication process of the nanoporous membrane. More importantly, the incorporation of new materials and the range of processes now extend far beyond just those found in the IC industry.

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Authors and Affiliations

  1. Department of Bioengineering and Physiology, University of California, San Francisco, CA

    Tejal A. Desai

  2. IMEDD Inc., Columbus, OH, 43212

    Teri West, Michael Cohen, Tony Boiarski & Arfaan Rampersaud

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  1. Tejal A. Desai
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  2. Teri West
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  3. Michael Cohen
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  5. Arfaan Rampersaud
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Editor information

Editors and Affiliations

  1. Department of Biomedical Engineering, University of Texas Health Science Center, Houston, TX

    Mauro Ferrari Ph.D. (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth) (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth)

  2. University of Texas M.D. Anderson Cancer Center, Houston, TX

    Mauro Ferrari Ph.D. (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth) (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth)

  3. Rice University, Houston, TX

    Mauro Ferrari Ph.D. (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth) (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth)

  4. University of Texas Medical Branch, Galveston, TX

    Mauro Ferrari Ph.D. (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth) (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth)

  5. Houston, TX

    Mauro Ferrari Ph.D. (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth) (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth)

  6. Dept. of Bioengineering and Physiology, University of California, San Francisco, CA

    Tejal Desai

  7. Harvard—MIT Division of Health Sciences & Technology, Electrical Engineering & Computer Science, Massachusetts Institute of Technology, MA

    Sangeeta Bhatia

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Desai, T.A., West, T., Cohen, M., Boiarski, T., Rampersaud, A. (2006). Nanoporous Microsystems for Islet Cell Replacement. In: Ferrari, M., Desai, T., Bhatia, S. (eds) BioMEMS and Biomedical Nanotechnology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-25844-7_10

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