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Multichain Immune Recognition Receptor Signaling

From Spatiotemporal Organization to Human Disease

  • Book
  • © 2008

Overview

Editors:
  1. Alexander B. Sigalov

    1. Department of Pathology, University of Massachusetts Medical School, Worcester, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 640)

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Keywords

Table of contents (22 chapters)

  1. Front Matter

    Pages i-xxvii
    Download chapter PDF

  2. MIRRs: Structure and Physiological Function

    1. T-Cell Receptor

      • Jose M. Rojo, Raquel Bello, Pilar Portolés
      Pages 1-11

    2. B-Cell Receptor

      • Randall J. Brezski, John G. Monroe
      Pages 12-21

    3. Fc Receptors

      • Maree S. Powell, P. Mark Hogarth
      Pages 22-34

    4. Natural Killer Cell Receptors

      • Roberto Biassoni
      Pages 35-52

    5. Platelet Glycoprotein VI

      • Stephanie M. Jung, Masaaki Moroi
      Pages 53-63

  3. MIRR Signaling: Possible Mechanisms and the Techniques to Study and Visualize

    1. Clustering Models

      • Wolfgang W.A. Schamel, Michael Reth
      Pages 64-73

    2. Segregation Models

      • Elaine P. Dopfer, Mahima Swamy, Gabrielle M. Siegers, Eszter Molnar, Jianying Yang, Wolfgang W. A. Schamel
      Pages 74-81

    3. Kinetic Proofreading Model

      • Byron Goldstein, Daniel Coombs, James R. Faeder, William S. Hlavacek
      Pages 82-94

    4. Serial Triggering Model

      • Jacob Rachmilewitz
      Pages 95-102

    5. Conformational Model

      • Ruth M. Risueño, Angel R. Ortiz, Balbino Alarcón
      Pages 103-112

    6. Permissive Geometry Model

      • Susana Minguet, Wolfgang W.A. Schamel
      Pages 113-120

    7. Signaling Chain Homooligomerization (SCHOOL) Model

      • Alexander B. Sigalov
      Pages 121-163

    8. Visualization of Cell-Cell Interaction Contacts-Synapses and Kinapses

      • Michael L. Dustin
      Pages 164-182

    9. Visualization of Protein Interactions in Living Cells

      • Tomasz Zal
      Pages 183-197

  4. MIRR Signaling and Therapy of Immune Disorders

    1. Immunogenicity in Peptide-Immunotherapy: From Self/Nonself to Similar/Dissimilar Sequences

      • Darja Kanduc
      Pages 198-207

    2. Therapeutic Application of Transmembrane T and Natural Killer Cell Receptor Peptides

      • Nicholas Manolios, Marina Ali, Michael Amon, Veronika Bender
      Pages 208-219

    3. Fc Receptor Targeting in the Treatment of Allergy, Autoimmune Diseases and Cancer

      • Akira Nakamura, Tomohiro Kubo, Toshiyuki Takai
      Pages 220-233

    4. Therapeutic Blockade of T- Cell Antigen Receptor Signal Transduction and Costimulation in Autoimmune Disease

      • Joseph R. Podojil, Danielle M. Turley, Stephen D. Miller
      Pages 234-251

    5. MHC and MHC-Like Molecules: Structural Perspectives on the Design of Molecular Vaccines

      • Vasso Apostolopoulos, Eliada Lazoura, Minmin Yu
      Pages 252-267
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Editors and Affiliations

  • Department of Pathology, University of Massachusetts Medical School, Worcester, USA

    Alexander B. Sigalov

About the editor

ALEXANDER SIGALOV, PhD, is a Research Assistant Professor in the Department of Pathology at the University of Massachusetts Medical School in Worcester, Massachusetts, USA. His main research interests include protein intrinsic disorder and oligomericity in the context of transmembrane signal transduction, the molecular mechanisms underlying immune receptor-mediated signaling and ways to control these processes and thus to modulate the immune response, as well as the development and applications of novel targets and strategies for innovative immune therapy. He discovered and investigated a very unusual and unique biophysical phenomenon, the homooligomerization of intrinsically disordered proteins, thus providing the first evidence for the existence of specific interactions between unfolded protein molecules. In the field of immunology, he unraveled a long-standing mystery of transmembrane signaling and immune cell activation triggered by multichain immune recognition receptors. Later, he developed a novel concept of platelet inhibition and invented a novel class of platelet inhibitors. In the field of immune therapy, he proposed new therapeutic strategies for a variety of malignancies and immune disorders, including immunodeficiencies, inflammatory and autoimmune diseases, allergy and HIV. He is a member of the American Association for the Advancement of Science and the Biophysical Society, USA. Alexander Sigalov received his academic degrees (MSc in Chemistry and a PhD in Organic Chemistry) from Moscow State University, Russia.

Bibliographic Information

  • Book Title: Multichain Immune Recognition Receptor Signaling

  • Book Subtitle: From Spatiotemporal Organization to Human Disease

  • Editors: Alexander B. Sigalov

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-0-387-09789-3

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2008

  • Hardcover ISBN: 978-0-387-09788-6Published: 27 October 2008

  • Softcover ISBN: 978-1-4419-1887-1Published: 23 November 2010

  • eBook ISBN: 978-0-387-09789-3Published: 16 December 2008

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXVII, 357

  • Number of Illustrations: 67 b/w illustrations, 3 illustrations in colour

  • Topics: Oncology, Biomedicine general, Life Sciences, general

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