Abstract
A major goal of the present chapter is to try to provide a comprehensive framework that researchers can use to generate testable hypotheses about the autonomic influences on the heart. This will include a brief discussion of the differential autonomic influences on different cardiac effector tissues including sympathetic–parasympathetic interactions as well as the discussion of cardiovascular activation components and the baroreflex. In addition, we will briefly overview the genetics as well as the neural concomitants of impedance derived indices and heart rate variability (HRV). Another goal will be to expose researchers to the range of phenomena that might be related to measures of impedance cardiography and HRV. These include aspects of physiological regulation, emotional regulation, and cognitive regulation. Finally, we will try to present what we perceive to be some of the future challenges in using these important techniques.
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Notes
- 1.
Note: This is an updated and expanded version of a previous chapter, Thayer JF, Hansen AL, Johnsen BH: Non-invasive assessment of autonomic influences on the heart: Impedance cardiography and heart rate variability. In Luecken LJ, Gallo LC (eds.), Handbook of Physiological Research Methods in Health Psychology. Newbury Park, CA: Sage Publications, 2008, 183-209.
References
Ahern, G. L., Sollers, J. J., Lane, R. D., Labiner, D. M., Herring, A. M. et al (2001). Heart rate and heart rate variability changes in the intracarotid sodium amobarbital (ISA) test. Epilepsia, 42, 912–921.
Akay, M. (1997). Time Frequency and Wavelets in Biomedical Signal Processing. New York: IEEE Press.
Allen, J. J. B., Chambers, A. S., and Towers, D. N. (2007). The many metrics of cardiac chronotropy: a pragmatic primer and a brief comparison of metrics. Biol Psychol, 74, 243–262.
Appelhans, B. M., and Luecken, L. J. (2006). Heart rate variability as an index of regulated emotional responding. Rev Gen Psychol, 10, 229–240.
Arnett, D. K., Devereux, R. B., Kitzman, D., Oberman, A., Hopkins, P. et al (2001). Linkage of left ventricular contractility to chromosome 11 in humans: The HyperGEN study. Hypertension, 38, 767–772.
Arnsten, A. F. T., and Goldman-Rakic, P. S. (1998). Noise stress impairs prefrontal cortical cognitive function in monkeys: evidence for a hyperdopaminergic mechanism. Arch Gen Psychiatry, 55, 362–369.
Benarroch, E. E. (1997). The central autonomic network. In P. A. Low (Ed.), Clinical Autonomic Disorders, 2nd Ed (pp. 17–23). Philadelphia, PA: Lippincott-Raven.
Benarroch, E. E. (2008). The arterial baroreflex: functional organization and involvement in neurologic disease. Neurology, 71, 1733–1738.
Berne, R. M., and Levy, M. N. (2001). Cardiovascular Physiology. London: Mosby Press.
Berntson, G. G., Bigger, J. T., Eckberg, D. L., Grossman, P., Kaufmann, P. G. et al (1997). Heart rate variability: origins, methods, and interpretive caveats. Psychophysiology, 34, 623–648.
Bogert, L. W. J., and van Lieshout, J. J. (2005). Non-invasive pulsatile arterial pressure and stroke volume changes from the human finger. Exp Physiol, 90.4, 437–446.
Boomsma, D. I., van Baal, G. C., and Orlebeke, J. F. (1990). Genetic influences on respiratory sinus arrhythmia across different task conditions. Acta Genet Med Gemellol (Roma), 39, 181–191.
Brook, R. D., and Julius, S. (2000). Autonomic imbalance, hypertension, and cardiovascular risk. Am J Hypertens, 13, 112S–122S.
Busjahn, A., Voss, A., Knoblauch, H., Knoblauch, M., Jeschke, E. et al (1998). Angiotensin-converting enzyme and angiotensinogen gene polymorphisms and heart rate variability in twins. Am J Cardiol, 81, 755–60.
Coleman, T. G., Guyton, A. C., Cowley, A. W. Jr, Bower, J. D. et al (1977). Feedback mechanisms of arterial pressure control. Contrib Nephrol, 8, 5–12.
Coleman, W. M. (1921). On the correlation of the rate of heart beat, breathing, bodily movement, and sensory stimuli. J Physiol, 54, 213–217.
Cybulski, G., Michalak, E., Kozluk, E., Piatkowska, A., and Niewiadomski, W. (2004). Stroke volume and systolic time intervals: beat-to-beat comparison between echocardiography and ambulatory impedance cardiography in supine and tilted positions. Med Biol Eng Comput, 42, 707–711.
Doerr, D. F., Ratliff, D. A., Sithole, J., and Convertino, V. A. (2005). Stroke volume during orthostatic challenge: comparison of two non-invasive methods. Aviat, Space Environ Med, 76, 935–939.
Duschek, S., and Reyes del Paso, G. A. (2007). Quantification of cardiac baroreflex function at rest and during autonomic stimulation. J Physiol Sci, 57, 259–268.
Eckberg, D. L. (1997). Sympathovagal balance—a critical appraisal. Circulation, 96, 3224–3232.
Fagard, R. H., Pardaens, K., Staessen, J. A., and Thijs, L. (1996). Prognostic value of invasive hemodynamic measurements at rest and during exercise in hypertensive men. Hypertension, 28, 31–36.
Frijda, N. H. (1988). The laws of emotion. Am Psychol, 43, 349–358.
Giardino, N. D., Lehrer, P. M., and Edelberg, R. (2002). Comparison of finger plethysmograph to ECG in the measurement of heart rate variability. Psychophysiology, 35, 246–253.
Hesse, C., Charkoudian, N., Liu, Z., Joyner, M. J., and Eisenach, J. H. (2007). Baroreflex sensitivity inversely correlates with ambulatory blood pressure in healthy normotensive humans. Hypertension, 50, 41–46.
Hill, L. K., Siebenbrock, A., Sollers, J. J., and Thayer, J. F. (2009). All are measures created equal? Heart rate variability and respiration. Biomed Sci Instrum, 45, 71–76.
Hon, E. H. (1958). The electronic evaluation of the fetal heart rate. Am J Obstet Gynecol, 75, 1215–1230.
Houtveen, J. H., Rietveld, S., and de Geus, E. J. (2002). Contribution of tonic vagal modulation of heart rate, central respiratory drive, respiratory depth, and respiratory frequency to respiratory sinus arrhythmia during mental stress and physical exercise. Psychophysiology, 39, 427–436.
Jensen, L., Yakimets, J., and Teo, K. K. (1995). A review of impedance cardiography. Heart Lung, 24, 183–193.
Jose, A. D., and Collison, D. (1970). The normal range and determinants of the intrinsic heart rate in man. Cardiovasc Res, 4, 160–167.
Kay, S. M., and Marple, S. L. (1981). Spectral analysis—a modern perspective. Proc IEEE Inst Electr Electron Eng, 69, 1380–1419.
Kitney, R. I. (1980). An analysis of thermoregulatory influences on heart-rate variability. In R. I. Kitney & O. Rompelman (Eds.), The study of heart-rate variability (pp. 81–106). Oxford: Clarendon Press.
Kupper, N., Willemsen, G., Boomsma, D., and De Geus, E. J. C. (2006). Heritability of indices of cardiac contractility in ambulatory recordings. J Cardiovasc Electrophysiol, 17, 877–883.
Kupper, N., Willemsen, G., van den Berg, M., de Boer, D., Posthuma, D., et al (2004). Heritability of ambulatory heart rate variability. Circulation, 110, 2792–2796.
LaRover, M. T., and the ATRAMI investigators (1998). Baroreflex sensitivity and heart rate variability in prediction of total mortality after myocardial infarction. Lancet, 351, 478–484.
Levy, M. N. (1997). Neural control of cardiac function. Baillieres Clin Neurol, 6, 227–244.
Levy, M. N., and Martin, P. J. (1996). Autonomic control of cardiac conduction and automaticity. In J. T. Shepard & S. J. Vatner (Eds.), Nervous Control of the Heart (pp. 201–225). Amsterdam: Harwood Academic Publishers .
Levy, M. N., and Zieske, H. (1969). Autonomic control of cardiac pacemaker activity and atrioventricular transmission. J Appl Physiol, 27, 465–470.
Lohmeier, T. E. (2001). The sympathetic nervous system and long-term blood pressure regulation. Am J Hypertens, 14, 147S–154S.
Lohmeier, T. E., Irwin, E. D., Rossing, M. A., Serdar, D. J., and Kieval, R. S. (2004). Prolonged activation of the baroreflex produces sustained hypotension. Hypertension, 43, 306–311.
Mamivuo, J., and Plonsey, R. (1995). Bioelectromagnetism—Principles and Applications of Bioelectric and Biomagnetic Fields. New York: Oxford University Press.
McGrath, J. J., O’Brien, W. H., Hassinger, H. J., and Shah, P. (2005). Comparability of spot versus band electrodes for impedance cardiography. J Psychophysiol, 19, 195–203.
McKinley, P. S., Shapiro, P. A., Bagiella, E., Myers, M. M., DeMeersman, R. E. et al (2003). Deriving heart rate variability from blood pressure waveforms. J Appl Physiol, 95, 1431–1438.
Mensah, G. A., Pappas, T. W., Koren, M. J., Ulin, R. J. et al (1993). Comparison of the classification of the severity of hypertension by blood pressure level and by WHO criteria in the prediction of concurrent cardiac abnormalities and subsequent complications in essential hypertension. J Hypertens, 11, 1429–1440.
Miller, S. B., and Ditto, B. (1988). Cardiovascular responses to an extended aversive video game task. Psychophysiology, 25, 200–208.
Moak, J. P., Goldstein, D. S., Eldadah, B. A., Saleem, A., Holmes, C. et al (2007). Supine low frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation. Heart Rhythm, 4, 1523–1529.
Neumann, S. A., Lawrence, E. C., Jennings, J. R., Ferrell, R. E., and Manuck, S. B. (2005). Heart rate variability is associated with polymorphic variation in the choline transporter gene. Psychosom Med, 67, 168–171.
Niskanen, J. P., Tarvainen, M. P., Ranta-aho, P. O., and Karjalainen, P. A. (2004). Software for advanced HRV analysis. Comput Methods Programs Biomed, 76, 73–81
Ottaviani, C., Shapiro, D., Goldstein, I. B., James, J. E., and Weiss, R. (2006). Hemodynamic profile, compensation deficit, and ambulatory blood pressure. Psychophysiology, 43, 46–56.
Pagani, M. Lombardi, F., Guzzetti, S., Rimoldi, O., Furlan, R. et al (1986). Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympathovagal interaction in man and conscious dog. Circ Res, 59, 178–193.
Parati, G., Di Rienzo, M., and Mancia, G. (2000). How to measure baroreflex sensitivity: from the cardiovascular laboratory to daily life. J Hypertens, 18, 7–19.
Penaz, J. (1978). Mayer waves: history and methodology. Automedica, 2, 135–141.
Penttila, J., Helminen, A., Jartti,T., Kuusela, T., Huikuri, H. V. et al (2001). Time domain, geometrical and frequency domain analysis of cardiac vagal outflow: effects of various respiratory patterns. Clin Physiol, 21, 365–376.
Pincus, S. M. (2001). Assessing serial irregularity and its implications for health. Ann New York Acad Sci, 954, 245–267.
Porges, S. W. (1995). Orienting in a defensive world: mammalian modification of our evolutionary heritage. A Polyvagal Theory. Psychophysiology, 32, 301–318.
Porges, S. W., Doussard-Roosevelt, J. A., Portales, A. L., and Greenspan, S. I. (1996). Infant regulation of the vagal “brake” predicts child behavior problems: a psychobiological model of social. Dev Psychobiol, 29, 697–712.
Porges, S. W., Doussard-Roosevelt, J. A., Stifter, C. A., McClenny, B. D., and Riniolo, T. C.(1999). Sleep state and vagal regulation of heart period patterns in the human newborn: an extension of the polyvagal theory. Psychophysiology, 36, 14–21.
Ring, C., Burns, V. E., and Carroll, D. (2002). Shifting hemodynamics of blood pressure control during prolonged mental stress. Psychophysiology, 39, 585–590.
Roach, D., Wilson, W., Ricthie, D., and Sheldon, R. (2004) Dissection of long-range heart rate variability. J Am Coll Cardiol, 43, 2271–2277.
Saul, J. P. (1990). Beat-to beat variations of heart rate reflect modulation of cardiac autonomic outflow. News Physiol Sci, 5, 32–37.
Sherwood, A., Allen, M. T., Fahrenberg, J., Kelsey, R. M., Lovallo, W. R. et al (1990a). Methodological guidelines for impedance cardiography. Psychophysiology, 27, 1–23.
Sherwood, A., Dolan, C. A., and Light, K. C. (1990b). Hemodynamics of blood pressure responses during active and passive coping. Psychophysiology, 27, 656–668.
Snieder, H., Dong, Y., Barbeau, P., Harshfield, G. A., Dalageogou, C. et al (2002). Beta 2-adrenergic receptor gene and resting hemodynamics in European and African American youth. Am J Hypertens, 15, 973–979.
Snieder, H., Harshfield, G. A., and Treiber, F. A. (2003). Heritability of blood pressure and hemodynamics in African- and European-American youth. Hypertension, 41, 1196–1201.
Snieder, H., van Doornen, L. J. P., Boomsma, D., and Thayer, J. F. (2007). Sex differences and heritability of two indices of heart rate dynamics: a twin study. Twin Res Hum Genet, 10, 364–372.
Sollers, J. J., Sanford, T. A., Nabors-Oberg, R. E., Anderson, C. A., and Thayer, J. F. (2002). Examining changes in HRV in response to varying ambient temperature. IEEE Eng Med Biol Mag, 21, 30–34.
Stein, P. K., and Kleiger, R. E. (1999). Insights from the study of heart rate variability. Annu Rev Med, 50, 249–261.
Stemmler, G., Grossman, P., Schmid, H., and Foerster, F. (1991). A model of cardiovascular activation components for studies using autonomic receptor antagonists. Psychophysiology, 28, 367–382.
Sztajzel, J. (2004). Heart rate variability: a noninvasive electrocardiographic method to measure the autonomic nervous system. Swiss Med Wkly, 134, 514–522.
Tang, W., Arnett, D. K., Devereux, R. B., Province, M. A., Atwood, L. et al (2002). Sibling resemblance for left ventricular structure, contractility, and diastolic filling. Hypertension, 40, 233–238.
Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. (1996). Heart rate variability: Standards of measurement, physiological interpretation, and clinical use. Circulation, 93, 1043–1065.
Thayer, J. F., Hansen, A. L., Saus-Rose E., and Johnsen, B. H. (2009). Heart rate variability, prefrontal neural function and cognitive performance: the Neurovisceral Integration perspective on self-regulation, adapttion, and health. Ann Behavl Med, 37, 141–153.
Thayer, J. F., and Lane, R. D. (2000). A model of neurovisceral integration in emotion regulation and dysregulation. J Affect Disord, 61, 201–216.
Thayer, J. F., and Lane, R. D. (2007). The role of vagal function in the risk for cardiovascular disease and mortality. Biol Psychol, 74, 224–242.
Thayer, J. F., and Lane, R. D. (2009). Claude Bernard and the heart-brain connection: further elaboration of a model of Neurovisceral Integration. Neurosci Biobehav Rev, 33, 81–88.
Thayer, J. F., Merritt, M. M., Sollers, J. J., Zonderman, A. B., Evans, M. K. et al (2003). Effect of angiotensin-converting enzyme insertion/deletion polymorphism DD genotype on high-frequency heart rate variability in African Americans. Am J Cardiol, 92, 1487–1490.
Thayer, J. F., Sollers, J. J., Ruiz-Padial, E., and Vila, J. (2002). Estimating respiratory frequency from autoregressive spectral analysis of heart period. IEEE Eng Med Biol Mag, 21, 41–45.
Thayer, J. F., and Uijtdehaage, S. H. J. (2001). Derivation of chronotropic indices of autonomic nervous system activity using impedance cardiography. Biomed Sci Instrum, 37, 331–336.
Thrasher, T. N. (2006). Arterial baroreceptor input contributes to long-term control of blood pressure. Curr Hypertens Rep, 8, 249–254.
Tzeng, Y. C., Larsen, P. D., and Galletly, D. C. (2003). Cardioventilatory coupling in resting human subjects. Exp Physiol, 88.6, 775–782.
Uijtdehaage, S. B. H., and Thayer, J. F. (2000). Accentuated antagonism in the control of human heart rate. Clin Auton Res, 10, 107–110.
Wallin, B. G. (2006). Regulation of sympathetic nerve traffic to skeletal muscle in resting humans. Clin Auton Res, 16, 262–269.
Wang, X., Ding, X., Su, S., Li, Z., Riese, H. et al (2009). Genetic influences on heart rate variability at rest and during stress. Psychophysiology, 46, 458–465.
Wang, X., Thayer, J. F., Treiber, F., and Snieder, H. (2005) Ethnic differences and heritability of heart rate variability in African- and European American youth. Am J Cardiol, 96, 1166–1172.
Wesseling, K. H., Jansen, J. R., Settels, J. J., and Schreuder, J. J. (1993). Computation of aortic flow from pressure in humans using a nonlinear, three-element model. J Appl Physiol, 74, 2566–2573.
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Thayer, J.F., Hansen, A.L., Johnsen, B.H. (2010). The Non-invasive Assessment of Autonomic Influences on the Heart Using Impedance Cardiography and Heart Rate Variability. In: Steptoe, A. (eds) Handbook of Behavioral Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-09488-5_47
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