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Perioperative and Critical Care Medicine pp 73–80Cite as

Strategies To Modify Lung Remodelling in the Acute Respiratory Distress Syndrome

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Abstract

Acute and chronic lung disorders, such as the acute respiratory distress syndrome (ARDS), asthma, chronic obstructive pulmonary diseases and interstitial lung diseases, are a major cause of morbidity and mortality, and an enormous burden on world healthcare systems. A feature of these diseases is the destruction and remodelling of the lung’s support structures, including its extracellular matrix. When this occurs in the fine structures of the lung, it has deleterious effects on lung function. This is seen in many disease settings, including diseases of the airways such as asthma and chronic obstructive pulmonary disease (COPD) — where excessive matrix deposition may occur in large or small airways — and in parenchymal diseases, such as ARDS and idiopathic pulmonary fibrosis (IPF), where there is excessive deposition in alveolar structures and severely compromised gas exchange.

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Authors and Affiliations

  1. Centre for Respiratory Research, Rayne Institute, Royal Free & University, College Medical School, London, UK

    G. J. Laurent

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  1. G. J. Laurent
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Editors and Affiliations

  1. Department of Perioperative Medicine, Intensive Care and Emergency, Trieste University School of Medicine, Trieste, Italy

    Antonino Gullo  & Giorgio Berlot  & 

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© 2006 Springer-Verlag Italia

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Laurent, G.J. (2006). Strategies To Modify Lung Remodelling in the Acute Respiratory Distress Syndrome. In: Gullo, A., Berlot, G. (eds) Perioperative and Critical Care Medicine. Springer, Milano. https://doi.org/10.1007/88-470-0417-9_6

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  • DOI: https://doi.org/10.1007/88-470-0417-9_6

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0416-0

  • Online ISBN: 978-88-470-0417-7

  • eBook Packages: MedicineMedicine (R0)

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