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Multiphysics Computational Modeling in Cartilage Tissue Engineering

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Computational Modeling in Tissue Engineering

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 10))

Abstract

A common technique for in vitro cartilage regeneration is to seed a porous matrix with cartilage cells and to culture the construct in static conditions or under medium perfusion in a bioreactor. An essential step toward the development of functional cartilage is to understand and control the tissue growth phenomenon in such systems. The growth process depends on various space- and time-varying biophysical variables of the environment surrounding the cartilage cells, primarily mass transport and mechanical variables, all involved in the cell biological response. Moreover, the growth process is inherently multiscale, since cell size (10 μm), scaffold pore size (100 μm), and cellular construct size (10 mm) pertain to three separate spatial scales. To obtain a quantitative understanding of cartilage growth in this complex multiphysics and multiscale system, advanced mathematical models and efficient scientific computing techniques have been developed. In this chapter, we discuss the existing knowledge in this field and we present the most recent advancements for the numerical simulation of cartilage tissue engineering.

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Acknowledgments

This research is funded by Politecnico di Milano, under grant 5 per Mille Junior 2009 CUPD41J10000490001 “Computational Models for Heterogeneous Media. Application to Micro Scale Analysis of Tissue-engineered Constructs”, by the Italian Institute of Technology (IIT-Genoa), under grant “Biosensors and Artificial Bio-systems”, and by the Cariplo Foundation (Milano), under grant 2010 “3D Micro structuring and Functionalisation of Polymeric Materials for Scaffolds in Regenerative Medicine”.

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Authors and Affiliations

  1. LaBS, Department of Structural Engineering, Politecnico di Milano, Milan, Italy

    Manuela Teresa Raimondi & Matteo Laganà

  2. Department of Mathematics, Università degli Studi di Milano, Milan, Italy

    Paola Causin

  3. MOX, Department of Mathematics, Politecnico di Milano, Milan, Italy

    Paolo Zunino

  4. Department of Mathematics, Politecnico di Milano, Milan, Italy

    Riccardo Sacco

Authors
  1. Manuela Teresa Raimondi
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  2. Paola Causin
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  3. Matteo Laganà
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  4. Paolo Zunino
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  5. Riccardo Sacco
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Corresponding author

Correspondence to Manuela Teresa Raimondi .

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Editors and Affiliations

  1. , Biomechanics Research Unit, University of Liège, Chemin des Chevreuils 1–BAT 52/3, Liège 1, 4000, Belgium

    Liesbet Geris

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Raimondi, M.T., Causin, P., Laganà, M., Zunino, P., Sacco, R. (2011). Multiphysics Computational Modeling in Cartilage Tissue Engineering. In: Geris, L. (eds) Computational Modeling in Tissue Engineering. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2011_112

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  • DOI: https://doi.org/10.1007/8415_2011_112

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