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A Duet Between Histamine and Oleoylethanolamide in the Control of Homeostatic and Cognitive Processes

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The Functional Roles of Histamine Receptors

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 59))

Abstract

In ballet, a pas de deux (in French it means “step of two”) is a duet in which the two dancers perform ballet steps together. The suite of dances shares a common theme of partnership. How could we better describe the fine interplay between oleoylethanolamide (OEA) and histamine, two phylogenetically ancient molecules controlling metabolic, homeostatic and cognitive processes? Contrary to the pas de deux though, the two dancers presumably never embrace each other as a dancing pair but execute their “virtuoso solo” constantly exchanging interoceptive messages presumably via vagal afferents, the blood stream, the neuroenteric system. With one exception, which is in the control of liver ketogenesis, as in hepatocytes, OEA biosynthesis strictly depends on the activation of histaminergic H1 receptors. In this review, we recapitulate our main findings that evidence the interplay of histamine and OEA in the control of food consumption and eating behaviour, in the consolidation of emotional memory and mood, and finally, in the synthesis of ketone bodies. We will also summarise some of the putative underlying mechanisms for each scenario.

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Authors and Affiliations

  1. Dipartimento di Neuroscienze, Psicologia, Area del farmaco e Salute del Bambino, Florence, Italy

    Gustavo Provensi & Patrizio Blandina

  2. Dipartimento di Scienze della Salute, Universitá di Firenze, Florence, Italy

    Alessia Costa, Barbara Rani & M. Beatrice Passani

Authors
  1. Gustavo Provensi
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  2. Alessia Costa
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  3. Barbara Rani
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  4. Patrizio Blandina
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  5. M. Beatrice Passani
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Corresponding author

Correspondence to M. Beatrice Passani .

Editor information

Editors and Affiliations

  1. Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan

    Kazuhiko Yanai

  2. Department of Health Science, University of Florence, Firenze, Italy

    Maria Beatrice Passani

Additional information

This article is dedicated to Ivan Izquierdo to whom we owe immense gratitude for his guidance in science and life.

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Provensi, G., Costa, A., Rani, B., Blandina, P., Passani, M.B. (2021). A Duet Between Histamine and Oleoylethanolamide in the Control of Homeostatic and Cognitive Processes. In: Yanai, K., Passani, M.B. (eds) The Functional Roles of Histamine Receptors. Current Topics in Behavioral Neurosciences, vol 59. Springer, Cham. https://doi.org/10.1007/7854_2021_236

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