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Behavioral Neurobiology of Bipolar Disorder and its Treatment pp 51–67Cite as

Clinical Endophenotypes for Bipolar Disorder

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Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 5))

Abstract

Although twin, family, and adoption studies demonstrate that bipolar disorder (BPD) is substantially heritable, the molecular genetic basis for this illness remains elusive. Given evidence that genes predisposing to BPD may be transmitted without expression of the clinical phenotype, interest has arisen in developing endophenotypes – indicators of processes mediating between genotype and phenotype. Patients with BPD have subtle neuropsychological abnormalities, even during periods of symptom remission. Some of these neurocognitive deficits are present in unaffected family members of probands with BPD, suggesting that these measures may be quantitative endophenotypes for the disorder. Similarly, BPD is associated with specific personality traits (e.g., reduced inhibition, increased risk-taking) that have been observed in both affected individuals and their family members. In this chapter, we review the evidence for candidate neurocognitive and personality endophenotypes for BPD. We conclude that neurocognitive and personality traits appear to be appropriate endophenotypes for BPD, suggesting that these measures share some genetic factors with the illness.

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Authors and Affiliations

  1. Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, 200 Retreat Avenue, Hartford, CT, 06106, USA

    David C. Glahn

  2. Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT, 06511, USA

    David C. Glahn

  3. Department of Psychiatry, Albert Einstein College of Medicine, New York, NY, USA

    Katherine E. Burdick

  4. The Feinstein Institute for Medical Research-North Shore-Long Island Jewish Health, Manhasset, NY, USA

    Katherine E. Burdick

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Correspondence to David C. Glahn .

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  1. Research & Development, LLC, Johnson & Johnson Pharmaceutical, Trenton-Habourton Road 1125, Titusville, 08560, New Jersey, USA

    Husseini K. Manji

  2. Mark O. Hatfield Clinical Res. Center, Lab. of Molecular Pathophysiology, National Institute of Mental Health, Center Drive 10, Bethesda, 20892, Maryland, USA

    Carlos A. Zarate Jr.

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Glahn, D.C., Burdick, K.E. (2010). Clinical Endophenotypes for Bipolar Disorder. In: Manji, H., Zarate Jr., C. (eds) Behavioral Neurobiology of Bipolar Disorder and its Treatment. Current Topics in Behavioral Neurosciences, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2010_70

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