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Progress in the Development of Agents to Control the Cell Cycle

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Cancer

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 1))

Abstract

Inhibitors of the kinases controlling the cell cycle have emerged as an important therapeuticmodality for the treatment of cancer. Drug discovery efforts have focused on inhibitors of the cyclin-dependentkinases, the Aurora kinases, and Polo-like kinases. Agents for each kinase are now advancing in humanclinical trials. In this review we will summarize the work in this area with special emphasis onthe structural biology and structure–activity relationships developed for the many chemotypesexplored.

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Authors and Affiliations

  1. Oncology Research Team, Spring House Research and Early Development Site, Johnson & Johnson PharmaceuticalResearch and Development, Welsh and McKean Roads, 19477, Springhouse, PA, USA

    Kevin J. Moriarty, Holly Koblish, Dana L. Johnson & Robert A. Galemmo Jr

Authors
  1. Kevin J. Moriarty
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  2. Holly Koblish
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  3. Dana L. Johnson
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  4. Robert A. Galemmo Jr
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Correspondence to Robert A. Galemmo Jr .

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Robert H. Bradbury

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© 2007 Springer-Verlag Berlin Heidelberg

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Moriarty, K.J., Koblish, H., Johnson, D.L., Galemmo, R.A. (2007). Progress in the Development of Agents to Control the Cell Cycle. In: Bradbury, R.H. (eds) Cancer. Topics in Medicinal Chemistry, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7355_2006_006

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